Klenzit-S

General characteristics. Structure:

Active agents: адапален (micronized) - 1 mg, clindamycin - 10,0 mg.

Excipients: dinatrium эдетат, carbomer 940 (карбопол 940), propylene glycol, methylparahydroxybenzoate, phenoxyethanol, half-oxameasures 407, sodium hydroxide, the water purified.

Pharmacological properties:

The combined drug for external use. Active ingredients of the drug Klenzit-S are адапален and clindamycin.
Adapalen - the retinoid metabolite possessing antiinflammatory action has also expressed komedonolitichesky activity (influences the opened and closed comedones), normalizes processes of keratinization and epidermal differentiation. Reduces binding of the follicular epithelial cells participating in formation of microcomedones. Suppresses a chemotaxis and hemokinetichesky reactions of polynuclear cells at the person.
Clindamycin a bacteriostatic antibiotic from group of linkozamid, possesses a broad spectrum of activity, communicates with 50S in subunit of a ribosomalny membrane and suppresses synthesis of protein in a microbic cell. Concerning a number of gram-positive cocci perhaps bactericidal action. It is active concerning Staphylococcus spp.
(including Staphylococcus epidermidis which are producing and not producing a penicillinase), Streptococcus spp. (excepting Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., anaerobic and mikroaerofilny gram-positive cocci (including Peptococcus spp. And Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., эубактериум and Actinomyces israelii. The majority of strains of Clostridium perfringens are sensitive to clindamycin, but other types of Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are steady against its action in this connection at the infections caused by Clostridium spp., definition of an antibiotikogramma is recommended.
Between clindamycin and lincomycin there is a cross stability.

Pharmacokinetics. System absorption of drug at external use is insignificant.

Indications to use:

Acne rash.

Route of administration and doses:

Outwardly. Before use of Klenzit-S gel it is necessary to clear and dry up skin. Evenly to apply with a light touch gel on affected areas of skin once a day before going to bed, avoiding hit of drug in eyes, on lips and other mucous membranes. The course of treatment makes from two to four weeks.
The repeated course of treatment is possible after consultation with the doctor.

Features of use:

At initial stages of treatment the exacerbation of acne rash which disappears in the course of treatment can be observed. At irritation of skin to stop gel use (temporarily or absolutely). To avoid stay to the sun and uses of artificial Uv-radiation (sunbed). In case of need long stay not to apply gel on the sun a day before and day after solar exposure. Not to use at the same time cosmetics with the drying-up or irritating effect (for example, cologne or etanolsoderzhashchy means). Use of gel for treatment of the injured skin and burns is not allowed.

Side effects:

Hyperemia and peeling of skin in the place of application, the burning sensation is rare. Allergic reactions.

Interaction with other medicines:

Co-administration from benzoyl peroxide is possible. It is incompatible with the solutions containing a complex of vitamins of group B, aminoglycosides, ampicillin, calcium a gluconate and magnesium sulfate. Shows antagonism with erythromycin.

Contraindications:

Hypersensitivity to drug components, pregnancy, the lactation period.

With care
Dermatitis, eczema.

Pregnancy and lactation
During pregnancy and a lactation use of drug is not recommended.

Overdose:

There are no data.

Storage conditions:

In the place protected from light, at a temperature from 2 °C to 25 °C.
To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Gel for external use. In tubas from the laminated foil on 15 g and on 30 g. One tuba together with the application instruction is located in a cardboard pack.