Artra

General characteristics. Structure:

Active agents: Glycosamine hydrochloride of 500 mg; Chondroitin sodium sulfate of 500 mg;

Excipients: calcium phosphate disubstituted, microcrystallic cellulose, sodium of a kroskarmelloz, stearic acid, magnesium stearate.

Cover: hydroxypropyl methyl cellulose, titanium dioxide (E171), triacetin.

Pharmacological properties:

Stimulates regeneration of cartilaginous tissue. The glycosamine and chondroitin sodium sulfate take part in biosynthesis of connecting fabric, promoting prevention of processes of destruction of a cartilage and stimulating fabric regeneration. Introduction of an exogenous glycosamine strengthens development of a cartilaginous matrix and provides nonspecific protection, including against NPVP and glucocorticosteroids (GKS). Drug possesses moderate antiinflammatory action.
Chondroitin sodium sulfate irrespective of whether it is soaked up in an intact form or in the form of separate components, serves as additional substrate for formation of a healthy cartilaginous matrix. Stimulates formation of proteoglycans and collagen like II, and also protects a cartilaginous matrix from zymolysis (by suppression of activity of hyaluronidase) and from the damaging action of free radicals; maintains viscosity of synovial fluid, stimulates mechanisms of a reparation of a cartilage and suppresses activity of those enzymes (elastase, hyaluronidase) which split a cartilage. At treatment of an osteoarthritis facilitates symptoms of a disease and reduces the need for NPVP.

Pharmacokinetics. Bioavailability of a glycosamine at oral administration - 25% (effect of "the first passing" through a liver). It is distributed in fabrics: the greatest concentration are found in a liver, kidneys and a joint cartilage. About 30% of the accepted dose are long persistirut in bone and muscular tissue. It is excreted preferential with urine in an invariable look; partially with a stake. T1/2 – 68 h. Bioavailability sulfate chondroitin about 13%.

Indications to use:

Osteoarthrosis of peripheral joints and backbone.

Route of administration and doses:

Inside. To adults and children 15 years on 1 tablet 2 times a day within the three first weeks are more senior; on 1 tablet once a day within the next weeks and months.
The steady medical effect is reached at administration of drug not less than 6 months.

Side effects:

Glycosamine: easy dysfunctions of a GIT (pain in epigastriums, a meteorism, diarrhea, a lock), dizziness, skin allergic reactions are possible. Chondroitin: allergic reactions.

Interaction with other medicines:

Strengthening of effect of anticoagulants and antiagregant is possible. Артра® increases absorption of tetracyclines, reduces effect of semi-synthetic penicillin. Drug is compatible to glucocorticoid drugs.

Contraindications:

Hypersensitivity, the expressed renal failure.
With care: bleedings or tendency to bleedings, bronchial asthma, diabetes mellitus. It is not recommended to accept during pregnancy and a lactation.

Overdose:

Symptoms: cases of overdose are unknown. Treatment: gastric lavage, symptomatic therapy.

Storage conditions:

At a temperature of 10-30 °C, in the dry place. To store in the place, unavailable to children. Period of validity of 5 years. Not to use after a period of validity.

Issue conditions:

Without recipe

Packaging:

Tablets are film coated.
On 30, 60, 100 or 120 tablets film coated in a white bottle from polyethylene of high density with the screwing-up cover from the same material and the safety valve from a foil. On a bottle paste the label, a bottle cover with polyethylene film and together with the application instruction place in a cardboard pack.