Xantinoli nicotinas

General characteristics. Structure:

Active ingredient: 150 mg of Xantinoli nicotinas in 1 ml of solution.

Excipients: water for injections.

Pharmacological properties:

Pharmacodynamics. Xantinoli nicotinas combines properties of medicines of group of theophylline and niacin: has anti-modular effect, expands peripheral vessels, improves collateral circulation. Blocking adenosine receptors and phosphodiesterase, increases the content of cyclic adenosinemonophosphate in a cell, substratno stimulates synthesis of nicotinamide adenine dinucleotide (NAD) and a nikotinamidadenindinukleotidfosfat (NADF).

Improves microcirculation, oxygenation and food of fabrics, at long use has antiatero-sclerous effect, activates processes of a fibrinolysis, reduces concentration of cholesterol and atherogenous lipids, increases activity of lipoproteinlipase, reduces viscosity of blood, reduces aggregation of thrombocytes.

Reducing the general peripheric vascular resistance, promotes increase in minute volume of blood and strengthening of cerebral circulation, reduces expressiveness of effects of a cerebral hypoxia.

Indications to use:

As a part of complex therapy: obliterating atherosclerosis of vessels of extremities, Raynaud's disease, obliterating endarteritis, diabetic angiopatiya, acute thrombophlebitis (superficial and deep veins), trophic ulcers of shins, cerebrovascular insufficiency, atherosclerosis of vessels of a brain, disturbance of cerebral circulation, atherosclerosis of coronary arteries, hypercholesterolemia, gipertriglitseridemiya.

Route of administration and doses:

Intravenously (struyno or kapelno), intramusculary. Severity of a disease, a condition of the patient and a way of administration of drug are estimated by the doctor.

At intramuscular introduction - on 2-6 ml of 15% of solution daily within 2-3 weeks.

At intravenous jet administration - on 2 ml of 15% of solution 1-2 times a day within 5-10 days (the patient at the same time has to be in horizontal position).

At intravenous drop administration - with a speed of 40-50 thaws a minute, having parted 10 ml of 15% of solution in 200-500 ml of 5% of solution of a dextrose or in 200 ml of 0,9% of solution of sodium of chloride.

Features of use:

Pregnancy and lactation. In the second and third trimester of pregnancy and in the period of a lactation use of drug is admissible only in the presence of absolute indications and careful observation of the doctor.

Drug can cause dizziness, weakness and a lowering of arterial pressure, in this regard during treatment it is necessary to refrain from driving of motor transport and occupations potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

To avoid hit in eyes or on mucous membranes.

Side effects:

Feeling of heat, pricking and erubescence of an upper body, especially necks and heads. These symptoms usually disappear in 10-20 min., do not demand special treatment and the termination of therapy by this drug.

Lowering of arterial pressure, weakness, dizziness, nausea, diarrhea, loss of appetite, gastralgia.

At long appointment in high doses drug causes change of tolerance to glucose, increase in activity of "hepatic" transaminases, an alkaline phosphatase, a hyperuricemia.

Interaction with other medicines:

It is necessary to be careful at co-administration of Xantinoli nicotinas and hypotensive medicines, including (beta adrenoblockers, alpha adrenoblockers, sympatholytics, ganglioblokator).

Not to apply together with monoamine oxidase inhibitors and strophanthin (strofantin-K).

Contraindications:

Chronic heart failure, acute bleeding, acute myocardial infarction, mitral stenosis, peptic ulcer of a stomach and 12-perstny gut (in an aggravation phase), arterial hypotension, pregnancy, an acute renal failure, glaucoma; to children up to 3 years.

Overdose:

The acute overdose of Xantinoli nicotinas is followed by a lowering of arterial pressure, weakness, dizziness, tachycardia, abdominal pains and vomiting.

At emergence of symptoms of overdose symptomatic therapy is appointed.

Storage conditions:

To store in the place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 3 years. Not to use drug after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for intramuscular and intravenous administration of 150 mg/ml on 2 ml in ampoules. On 5 ampoules in a blister strip packaging from a film polyvinyl chloride. 1 or 2 blister strip packagings with the scarificator ampoule ceramic or a knife for opening of ampoules and the application instruction in a pack from a cardboard. When using ampoules with a ring of a break or a point of a break the knife or the scarificator do not put.