Генферон® Light

General characteristics. Structure:

Active agent: 500 000 ME of interferon alpha 2b, 1 mg of taurine.

Excipients: dinatrium of an edetat a dihydrate, глицерол, a dextran 40000, polysorbate 80 of, sodium chloride, potassium chloride, hydrophosphate sodium dodecahydrate, potassium dihydrophosphate, peppermint oil, methylparahydroxybenzoate, water for injections enough.

Pharmacological properties:

Pharmacodynamics. Immunobiological properties. Ron alpha 2b, Escherichia coli developed by a strain of a bacterium into which methods of genetic engineering entered a gene of interferon alpha 2b the person is a part of the drug GENFERON® LIGHT recombinant human interfe-.

Interferon alpha 2b renders antiviral, immunomodulatory, antiproli-ferativny and antibacterial action. The antiviral effect is mediated by activation of a number of the desmoenzymes inhibiting replication of viruses. Immunomodulatory action is shown, first of all, by strengthening kletoch-but - the mediated reactions of immune system that increases efficiency immune го the answer concerning viruses, the intracellular parasites and cells which underwent tumoral transformation. It is reached due to activation of CD8+ of T-killers, NK cells (natural killers), strengthening of a differentiation of V-lymphocytes and products of antibodies by them, activation of monocytic and macrophagic system and phagocytosis, and also increase in an expression of molecules of the main complex of histocompatability of the I type that increases probability of recognition of the infected cells cells of immune system. Activation under the influence of interferon of the leukocytes which are contained in all layers of a mucous membrane provides their active participation in elimination patolo-the gichesky centers; besides, due to influence of interferon recovery of products of secretory immunoglobulin A is reached. The antibacterial effect is mediated by the reactions of immune system strengthened under the influence of interferon.

Taurine contributes to normalization of metabolic processes and an angenesis, possesses membrane stabilizing and immunomodulatory action. Being strong antioxidant, taurine directly interacts with active forms of oxygen which excess accumulation promotes development pathologists - chesky processes. Taurine promotes preservation of biological activity interfe-Rhone, strengthening therapeutic effect of use of drug.

Pharmacokinetics. At intranasal use due to high concentration in the infection center dostiga-the antiviral and immunostimulating effect expressed local etsyatsya.

System absorption of drug is insignificant — low bioavailability of medicines at intranasal introduction is connected with functioning of special family of proteins from 25 proteins which are a part of a mucous membrane of a nasal cavity and kontroliru-yushchy transport of all molecular and cellular objects getting through mucous. At the same time, a quantity of drug gets to a system blood stream at the expense of what the system immunomodulatory effect is reached.

Indications to use:

Prevention and treatment of flu and SARS at adults and children are more senior than 14 years.

Route of administration and doses:

Drug is used intranazalno by aerosol introduction of 1 dose (1 dose = 1 short pressing the doser). At the first symptoms of disease ГЕНФЕРОН® LIGHT enter intranazalno within 5 days on one dose (one pressing the doser) into each nasal course 3 times a day (one dose approximately makes 50 000 ME of interferon an alpha, daily should not exceed 500 000 ME).

At contact with the patient of a SARS and/or when overcooling the drug is administered according to the specified scheme by 2 times a day within 5-7 days. If necessary preventive courses are repeated.

Application instruction of spray:
1. Remove a protective cap.
2. Before the use for the first time press the doser several times before emergence of a squirt.
3. At the use you keep a bottle in vertical position.
4. Make drug injection by single pressing the doser in each nasal course serially.
5. After the use close the doser a protective cap.

In order to avoid spread of an infection individual use is recommended.

Features of use:

Use during pregnancy and a lactation. Use during the entire period of pregnancy is allowed.

Side effects:

Side effects at use of the drug Genferon® light were not noted.

Interaction with other medicines:

It is noted.

Contraindications:

Hypersensitivity to interferon alpha 2b or to other components of drug. Children's age up to 14 years.

With care. It is necessary to appoint with care to the patients having nasal bleedings.

Overdose:

About cases of overdose of the drug Genferon® light it was not reported.

Storage conditions:

In the dry, protected from light place at a temperature from 2 to 8 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to apply after the expiry date specified on packaging.

Issue conditions:

Without recipe

Packaging:

On 100 doses of spray nasal in a bottle from dark neutral glass with a nozzle the sprayer. 1 bottle together with the application instruction in a pack from a cardboard.