Isoniazid

General characteristics. Structure:

Active ingredient: 0,3 g of an isoniazid.

Excipients: potato starch, calcium stearate.

Pharmacological properties:

Pharmacodynamics. Antituberculous remedy; works bakteritsidno, synthesis of the mikoliyevy acids which are the most important component of a cell wall of microbacteria oppresses. It is especially active concerning quickly breeding microorganisms (including located intracellularly).

Pharmacokinetics. Absorption – high (inclusion in time of food reduces absorption). Time of achievement of the maximum concentration of 2 h. Communication with proteins of plasma – 80%. An elimination half-life of 3 h (in 600 mg) and 5.1 h (900 mg).

At repeated appointments the period is shortened to 2-3 h. Is present at effective concentration in many fabrics and biological liquids, including spinal. Gets through a blood-brain barrier.

It Metabilizirutsya in a liver by acetylation to inactive products. About 30% of a dose (a half – in an invariable look) by kidneys, with bile are removed

Indications to use:

Tuberculosis (any localization at adults and children, treatment and prevention, including as a part of a combination therapy)

Route of administration and doses:

Inside, after food, to 600-900 mg/days in 1-3 receptions, the maximum single dose – 600 mg, daily – 900 mg; to children – on 5-15 mg/kg/days, frequency rate of reception 1-2 receptions of time a day, the maximum dose – 500 mg/days.

For the purpose of prevention – inside, on 5-10 mg/kg/days, in two steps in days, within 2 months.

During pregnancy and at a severe form of a pulmonary heart, the expressed atherosclerosis, coronary heart disease and arterial hypertension should not appoint more than 10 mg/kg in doses

Interaction with other medicines:

Simultaneous alcohol intake saosobstvut to strengthening of hepatotoxic infections.

Contraindications:

Hypersensitivity, epilepsy, epileptic syndrome, poliomyelitis (including in the anamnesis), bronchial asthma, psoriasis, a chronic renal failure, hepatitis, cirrhosis, phlebitis.

With care. A severe form of heart failure, arterial hypertension, an ischemic heart disease, widespread atherosclerosis, diseases of a nervous system, гипотериоз, pregnancy (not to appoint in a dose it is higher than 10 mg/kg).

Simultaneous alcohol intake saosobstvut to strengthening of hepatotoxic infections.

Storage conditions:

List B. In the dry place at a temperature not above 25 °C. In the place, unavailable to children. Period of validity of 5 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Tablets on 0,3 g. On 10 tablets in a blister strip packaging. 10 контурныех strip packagings with the application instruction place in a pack from a cardboard.