Sodium para-aminosalicylate

General characteristics. Structure:

Active ingredient: 80,0 g of sodium of para-aminosalicylate on 100 g of granules.

Excipients.

The antitubercular lekartsvenny drug which is often used for strengthening of polychemotherapy of tuberculosis.

Pharmacological properties:

Pharmacodynamics. P-aminosalicylic acid and its sodium salt (PASK) have bacteriostatic activity concerning tuberculosis mycobacteria. On tuberculostatic activity of PASK concedes to an isoniazid and streptomycin therefore it is combined with other, more active, antitubercular drugs (an isoniazid or other drugs of hydrazide of isonicotinic acid, Cycloserinum, Kanamycinum, etc.). The combination therapy slows down development of medicinal stability and mutually strengthens effect of the administered drugs.

Pharmacokinetics. At intake, PASK it is well soaked up and gets into blood serum and tissues of internals. It is metabolized in a liver. It is allocated from an organism preferential with kidneys (to 50% - in the form of metabolites). At disturbance of secretory function of kidneys the speed of removal decreases.

Indications to use:

Tuberculosis (various forms and localizations). It is used in a combination with other antitubercular drugs for treatment of patients with allocation of MBT steady against an isoniazid and rifampicin (MLU) in the individualized chemotherapy modes. For strengthening of medical effect at polychemotherapy tuberculosis.

Route of administration and doses:

Appoint PASK inside the adult on 9-12 g a day (3-4 g 3 times a day). To children – on 0,2 g/kg a day in 3-4 receptions (a daily dose no more than 10 g). Accept through 0,5-1ch after food, wash down with water. The exhausted adult patient (with mother of a body it is less than 50 kg), and also at bad portability drug give in a dose 6 g a day. In out-patient practice it is possible to appoint all daily dose in 1 reception, however at bad a nosimost feather the daily dose is divided into 2-3 receptions. Granules are better transferred, than pure PASK.

Features of use:

Aminosalicylic acid and its salts should be applied in a combination with other antituberculous remedies.

With extra care apply at patients with disturbances of functions of kidneys and a liver.

In the presence of aminosalicylates carrying out tests for a glucosuria in which the reagents containing copper are used is broken.

Side effects:

At intake gastrointestinal frustration are sometimes noted: deterioration (or loss) appetite, nausea, vomiting, abdominal pains, diarrhea or lock. These phenomena usually decrease at a dose decline or a short-term break in treatment, they are less expressed at correct (uniform thrice) a diet. At use of sodium of para-aminosalicylate allergic reactions (dermatitis like small tortoiseshell or a purpura, an enantema), feverish reaction, the asthmatic phenomena, joint pains, an eosinophilia, etc. can be also observed. Increase and morbidity of a liver are in some cases possible. Depending on character and expressiveness of the allergic phenomena it is necessary to stop reception temporarily or completely. Appoint antihistaminic drugs, Calcii chloridum, ascorbic acid, and at long allergic reactions - corticosteroid hormones. In the course of treatment it is necessary to investigate systematically urine and blood, to check a functional condition of a liver. In high doses of PASK has anti-thyroid effect. At prolonged use the goitrogenic effect can be observed. This feature of PASK needs to be considered if TB patients have a hypofunction of a thyroid gland.

Interaction with other medicines:

PASK slows down development of resistance to an isoniazid, slows down acetylation, competes with an isoniazid for the liver N-acetyltransferase metabolizing these drugs that leads to increase in concentration of GINK in blood. Breaks absorption of erythromycin, lincomycin. Breaks digestion of B12 vitamin owing to what perhaps development of anemia. Let's combine with other antitubercular drugs. It is necessary to appoint drug PASK not earlier than in 4 h after rifampicin reception since absorption disturbance is possible.

Contraindications:

The expressed pathology of kidneys (nephrite), a liver (hepatitises, cirrhosis), an amyloidosis, a peptic ulcer, a myxedema, a cordial decompensation. It is necessary to be careful at patients with moderately expressed digestive tract pathology.

Overdose:

Symptoms: strengthening of dozozavisimy side effects is possible.

Treatment: drug withdrawal, symptomatic therapy.

Storage conditions:

In the dry, protected from light place.

Issue conditions:

According to the recipe

Packaging:

Granules coated 4 g No. 1 or No. 10, pack cardboard; granules coated 100 g (800 mg / 1 гр.) No. 1, packs cardboard; granules coated 5 g (800 mg / 1 гр.) No. 10, or No. 100, packs cardboard.