Sodium granule para-aminosalicylate

General characteristics. Structure:

Excipients: ethyl cellulose, polyvinylpirrolidone middlemolecular (povidone), cellulose microcrystallic, sugar milk (lactose), shellac, oydragit, tropeolin O – up to 4 g.

Pharmacological properties:

Pharmacodynamics. Antituberculous bacteriostatic remedy. Competes with PABK and suppresses synthesis of folate in tuberculosis mycobacteria. Poorly influences on the activator which is located intracellularly.

Pharmacokinetics. Absorption - high; moderately gets into SMZh (only at an inflammation of covers). Easily passes gistogematichesky barriers and it is distributed in fabrics. It is metabolized, a half of a dose is defined in urine in the form of acetylized derivative. T1/2 - 30 min. The general clearance depends both on metabolism speed, and on removal by kidneys.

Indications to use:

Tuberculosis (various forms and localizations).

Route of administration and doses:

Inside, on 9-12 g/days in 3-4 receptions (in out-patient practice - 1 time a day); for the exhausted patients with body weight less than 50 kg - 6 g/days. To children appoint at the rate of 0.2 g/kg/days, the maximum dose - 10 g/days. A pill is taken in 0.5-1 h after food, washing down with water or milk, alkaline mineral water, weak (0.5-2%) Natrii hydrocarbonas solution. Granules are appointed teaspoons from calculation that 6 g of the granules holding in a spoon contain 2 g of aminosalicylic acid and 4 g of sugar (accepting on 1-2 h a spoon 3 times a day, the patient receives 6 or 12 g of active agent). Patients in whom reception in the form of tablets without covering causes gastrointestinal frustration are recommended to appoint drug in the form of granules or tablets, coated. At associated diseases of a GIT, initial forms of an amyloidosis the maximum daily dose - 4-6 g/days.

Features of use:

Apply in a combination with more active antitubercular HP. At treatment it is recommended to control activity of "hepatic" transaminases. Depression of function of kidneys against the background of tubercular intoxication or specific defeat are not a contraindication to appointment. Development of a proteinuria and hamaturia demand temporary drug withdrawal. With care. Epilepsy.

Side effects:

Loss of appetite, nausea, vomiting, meteorism, abdominal pain, diarrhea or locks, hepatomegalia, increase in activity of "hepatic" transaminases, hyperbilirubinemia; proteinuria, hamaturia, crystalluria. Seldom - thrombocytopenia, a leukopenia (up to an agranulocytosis), medicinal hepatitis, B12 - scarce megaloblastny anemia. Allergic reactions - fever, dermatitis (a small tortoiseshell, a purpura, an enantema), an eosinophilia, an artraygiya, a bronchospasm. At prolonged use in high doses - a hypothyroidism, a craw, a myxedema.

Interaction with other medicines:

Let's combine with other antitubercular HP. When sharing with an isoniazid increases its concentration in blood. Breaks absorption of rifampicin, erythromycin and lincomycin. Breaks digestion of B12 vitamin (risk of development of anemia).

Contraindications:

Hypersensitivity, renal failure, liver failure, hepatitis, cirrhosis; an amyloidosis of internals, a peptic ulcer of a stomach and a 12-perstny gut, a coloenteritis (aggravation), a myxedema (noncompensated), nephrite, dekompensirovanny HSN (including against the background of heart disease), thrombophlebitis, hypocoagulation, pregnancy, a lactation.

Storage conditions:

List B. In the dry, protected from light place, at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe