Metronidazol-Altfarm

General characteristics. Structure:

Deystvyushchy substance: 1 suppository contains metronidazole 0,125 g, 0,25 g or 0,5.

Excipients: a polyutilenoksida 1500, poly(ethylene oxide) 400 enough before receiving suppository weighing 1,2 g, 2.4 g.

Description: suppositories of color, white or white with a yellowish shade, torpedo-shaped form.

Pharmacological properties:

Pharmacodynamics. Metronidazole belongs to nitro-5-imidazoles. The mechanism of effect of metronidazole consists in biochemical recovery 5 nitrogroups of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5-nitro-group of metronidazole interacts with DNA of a cell of microorganisms, inhibiting synthesis of their nucleic acids that leads to death of microorganisms. Metronidazole is effective antimicrobic and antiprotozoan broad-spectrum agent. Drug shows high activity concerning protozoa: Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, LambIia intestinalis, Balantidium coli, Blastocystis hominis. Helicobacter pylori; concerning obligate anarob (sporo-and asporous): Bacteroides spp. (B.fragilis, B.ovatus, B.distasonis, B.thetaiotaomicron, V. vulgatus), Fusobacterium spp., Clostridiull1 spp., Peptostreptococcus spp., Peptococcus spp., sensitive strains of Eubacterium. Metronidazole is active concerning an optional anaerobic bacterium: GardnerelIu vaginalis.

Pharmacokinetics. After intravaginalny use metronidazole is absorbed slightly. Active ingredient is metabolized in a liver. Gets into breast milk and the majority of fabrics. Passes through GEB and a placenta. It is allocated for 40-70% (about 20% in an invariable form) through kidneys.

Indications to use:

Topical treatment mecotic and nonspecific vaginit.

Route of administration and doses:

Drug is used intravaginalno, I.e. entered into a vagina. Wash up hands and break off one cell with suppository on a notch. Release suppository from a cell. For this purpose separate edges of a tape from the acute party of suppository and pull for them in different directions. You enter suppository into a vagina the pointed end, whenever possible more deeply. Apply 1 suppository in a dose of 0,25 g to treatment of a mecotic vaginitis two times a day or the I suppository in a dose of 0,5 g within 10 days once a day. Apply 1 suppository in a dose of 0,5 g to treatment of a nonspecific vaginitis two times a day within 7 days.

Features of use:

Treatment by metronidazole should not continue more than 10 days and repeat more often than 2-3 times a year. At treatment of a mecotic vaginitis at women and a mecotic urethritis at men it is recommended to abstain from sexual contacts. At the vaginitis caused by Trichomonas vaginalis simultaneous treatment of the sexual partner by drug metronidazole for intake is recommended. In case of use of drug together with metronidazole for intake, especially at a repeated course control of a picture of peripheral blood (danger of a leukopenia) is necessary. During treatment ethanol reception is contraindicated (possibly development of disulfirampodobny reaction: spastic abdominal pains, nausea, vomiting, a headache, sudden rush of blood to the person. It is necessary to draw the attention of patients, especially drivers of vehicles and persons. managing directors of other mechanisms, on a possibility of emergence of the dizziness connected with administration of drug.

Side effects:

At local use emergence of the following side effects is possible:
- an itch, burning, pain and irritation in a vagina; dense, white, mucous allocations from an inodorous vagina or with a slight smell), the speeded-up urination; after drug withdrawal - development of candidiasis of a vagina is possible.
- a burning sensation or irritation of a penis at the sexual partner;
- from digestive tract: nausea, change of flavoring feelings, metal smack in a mouth, dryness in a mouth, a loss of appetite, spastic an abdominal cavity pains, nausea, vomiting, a lock or diarrhea;
- allergic reactions: urticaria, itch of integuments, rash;
- leukopenia or leukocytosis.
In rare instances coloring of urine in red-brown color, vsledsviya of presence of the water-soluble pigment which is formed as a result of metronidazole metabolism can be observed.

Interaction with other medicines:

Let's combine with streptocides and antibiotics. At treatment by metronidazole it is necessary to avoid alcohol intake (similar to Disulfiramum causes intolerance of alcohol). It is not necessary to combine metronidazole with Disulfiramum. As at interaction of these drugs consciousness oppression, development of mental disorders is possible. At simultaneous use with warfarin and other indirect anticoagulants metronidazole strengthens their action that leads to increase in a prothrombin time. It is not recommended to combine with not depolarizing muscle relaxants (vekuroniya). Under the influence of barbiturates decrease in effect of metronidazole as its inactivation in a liver accelerates is possible. Cimetidinum oppresses metronidazole metabolism that can lead to increase in its concentration in blood serum and to increase in risk of development of side reactions. At a concomitant use with lithium drugs. Concentration of the last in plasma can increase.

Contraindications:

Hypersensitivity to metronidazole or other nitroimidazolny derivatives; blood diseases, a leukopenia (including in the anamnesis); lack of coordination of movements, organic defeats of TsNS (including epilepsy); a liver failure (in case of purpose of high doses), pregnancy, the breastfeeding period.

Storage conditions:

List B. To store in the dry place protected from light at a temperature not above 25 °C. A period of validity - 2 years. Not to apply after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

On 5 suppositories in a blister strip packaging. 2 blister strip packagings together with the application instruction in a pack cardboard.