Kagotsel

General characteristics. Structure:

Active ingredient: 12 mg of a kagotsel.

Excipients: stearate, Ludipress rakhmat potato, calcium (lactose of direct pressing, structure: lactose monohydrate, povidone (Kollidon 30), кросповидон (Kollidon CL)).

Synthetic medicine of group of inductors of interferon. репарат possesses the antimicrobic, antiviral, immunostimulating and radio tire-tread action.

Pharmacological properties:

Pharmacodynamics. The main mechanism of action Kagotsela® is ability to induce products of interferon. Кагоцел® causes education in a human body of the so-called late interferon which is mix α and β the interferon having high antiviral activity. Кагоцел® causes products of interferon practically in all populations of the cells which are taking part in the antiviral answer of an organism: T - and In - lymphocytes, macrophages, granulocytes, fibroblasts, endothelial cells. At intake of one dose of Kagotsela® the interferon caption in blood serum reaches the maximum values in 48 hours. The interferon response of an organism to introduction of Kagotsela® is characterized long (up to 4-5 days) by circulation of interferon in a blood-groove. Dynamics of accumulation of interferon in intestines at intake of Kagotsela® does not match dynamics of credits of the circulating interferon. In blood serum products of interferon reach high values only in 48 hours after reception of Kagotsela® while in intestines the maximum of products of interferon is noted in 4 hours.

Кагоцел®, at appointment in therapeutic doses, it is non-toxical, does not collect in an organism. Means has no mutagen and teratogenic properties, is not cancerogenic and does not possess embriotoksichesky action.

Pharmacokinetics. In 24 hours after introduction to an organism of Kagotsel® collects, generally in a liver, to a lesser extent in lungs, a thymus gland, a spleen, kidneys, lymph nodes. Low concentration is noted in fatty tissue, heart, muscles, seed plants, a brain, a blood plasma. Low contents Kagotsela® in a brain is explained by the high molecular mass of means complicating its penetration through a blood-brain barrier. In a blood plasma means is preferential in the connected look.

At daily repeated introduction of Kagotsela® the volume of distribution fluctuates over a wide range in all studied bodies. Accumulation of means in a spleen and lymph nodes is especially expressed. At intake about 20% of the entered means dose get to the general blood stream. Soaked up means circulates in blood, generally in the form connected with macromolecules: with lipids - 47%, with proteins - 37%. An untied part of means makes about 16%.

Removal: means is brought out of an organism, generally through intestines: in 7 days after introduction 88% of the entered dose, including 90% - through intestines and 10% - kidneys are brought out of an organism. In expired air means it is not found.

Indications to use:

- To adult Kagotsel® it is recommended for treatment and prevention of a SARS and flu, and also for treatment of herpes.

- It is for children over 3 years applied to prevention and treatment of flu and other SARS.

Route of administration and doses:

For use inside.

   For treatment of flu and a SARS adult appoint in the first two days - 2 tablets 3 times a day, in the next two days - on one tablet 3 times a day. In total on a course - 18 tablets, course duration - 4 days.
   Prevention of flu and SARS at adults is carried out by 7-day cycles: two days - on 2 tablets once a day, 5 days to repeat a break, then the cycle. Duration of a preventive course - from one week to several months.
   For treatment of herpes at adults appoint 2 tablets 3 times a day within 5 days. In total on a course - 30 tablets, course duration - 5 days.
   For treatment of flu and a SARS to children aged from 3 up to 6 years appoint in the first two days - on 1 tablet 2 times a day, in the next two days - on one tablet of 1 time a day. In total on a course - 6 tablets, course duration - 4 days.
   For treatment of flu and a SARS to children aged from 6 years appoint in the first two days - on 1 tablet 3 times a day, in the next two days - on one tablet 2 times a day. In total on a course - 10 tablets, course duration - 4 days.
   Prevention of flu and SARS at children aged from 3 years is carried out by 7-day cycles: two days – on 1 tablet once a day, 5 days to repeat a break, then the cycle. Duration of a preventive course – from one week to several months.

Features of use:

For achievement of medical effect reception of Kagotsela® should be begun no later than the fourth day from the beginning of a disease.

Side effects:

Development of allergic reactions is possible.

Interaction with other medicines:

Кагоцел® it is well combined with other antiviral means, immunomodulators and antibiotics (the additive effect).

Contraindications:

The increased individual sensitivity, pregnancy, age up to 3 years, deficit of lactase, a lactose intolerance, glyukozo-galaktozny malabsorption.

Overdose:

At accidental overdose it is recommended to appoint plentiful drink, to cause vomiting.

Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 2 years.

Issue conditions:

Without recipe

Packaging:

Tablets of 12 mg.

On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil with the thermowelded covering.

1 planimetric packaging together with the application instruction is placed in a pack.