Tablet CYTOFLAVIN, covered with a kishechnorastvorimy cover

General characteristics. Structure:

Acting substances: succinic acid – 0,300 g, inosine (inosine) – 0,050 g, niacinamide – 0,025 g, Riboflavinum sodium phosphate (Riboflavinum) – 0,005 g; excipients: povidone – 0,00810 g, calcium stearate – 0,00390 g, a gipromelloza – 0,00360 g, polysorbate-80 – 0,00040 g; kishechnorastvorimy cover: methacrylic acid and ethyl acrylate copolymer – 0,02902 g, propylene glycol – 0,00291 g, dye an azoruby – 0,00004 g, dye tropeolin-O – 0,00003 g.

Description: round biconvex tablets, coated red color. On cross section two layers are visible. A kernel of tablets from yellow till yellow-orange color.

Pharmacological properties:

Pharmacodynamics. Pharmacological effects are caused by combined effect being a part of the drug CYTOFLAVIN of components. The Succinic Acid (SA) - the endogenous intracellular metabolite of a tricarbonic acid cycle performing the general power synthesizing function in organism cells. With the participation of a coenzyme of a flavinadenindinukleotid (FAD) succinic acid mitochondrial enzyme is quickly transformed by a succinatedehydrogenase to fumaric acid and further to other metabolites of a cycle of tricarboxylic acids. Stimulates aerobic glycolysis and synthesis of ATP in cells. An end product of metabolism of succinic acid in a tricarbonic acid cycle is carbon dioxide and water. Succinic acid improves tissue respiration due to activation of transport of electrons in mitochondrions. Riboflavinum (B2 vitamin) is a flavin coenzyme (FAD) activating a suktsinadegidrogenaza and other redoxreactions of a tricarbonic acid cycle. Niacinamide (RR vitamin), niacin amide. Niacinamide in cells, by the cascade of biochemical reactions, is transformed to a form of a nikotinamidadeninnukleotid (OVER) and its phosphate (NADF), activating niacinamide - dependent enzymes of a tricarbonic acid cycle, necessary for cellular respiration and stimulation of synthesis of ATP. Inosine is derivative purine, the predecessor of ATP. Has ability to activate a number of enzymes of a tricarbonic acid cycle, stimulating synthesis of key enzymes nucleotides: flavinadenindinukleotid (FAD) and nicotinamide adenine dinucleotide (NAD). Thus, all components of Tsitoflavin are natural metabolites of an organism and stimulate tissue respiration. The metabolic power correction, anti-hypoxemic and antioxidant activity of drug defining pharmacological properties and medical efficiency of components is caused by complementary effect of succinic acid, inosine, niacinamide and Riboflavinum.

Pharmacokinetics. CYTOFLAVIN has high bioavailability. Succinic acid at intake gets from digestive tract into blood and fabrics, participating in reactions of energy balance, and completely breaks up to end products of exchange (carbon dioxide and water) in 30 minutes. Inosine is well absorbed from digestive tract. Time of achievement of the maximum concentration in blood – 5 hours, the average time of deduction in blood – 5,5 hours, the equilibrium volume of distribution is about 20 liters. Inosine is metabolized in a liver with formation of an inozinmonofosfat with the subsequent its oxidation to uric acid. In insignificant quantity it is removed by kidneys. Niacinamide is quickly distributed in all fabrics (the equilibrium volume of distribution about 500 liters). Time of achievement of the maximum concentration in blood – 2 hours, the average time of deduction in blood – 4,5 hours. Niacinamide gets through a placenta and into breast milk; it is metabolized in a liver with formation of N-metilnikotinamida, removed by kidneys. Riboflavinum is quickly absorbed from digestive tract, distributed unevenly (the greatest number in a myocardium, a liver, kidneys), transformed in флавинаденинмононуклеотид (FMN) and флавинадениндинуклеотид (FAD) in mitochondrions. Gets through a placenta and into breast milk; it is removed by kidneys, it is preferential in the form of metabolites.

Indications to use:

At adults in complex therapy: – brain heart attack effects; – other cerebrovascular diseases (cerebral atherosclerosis, hypertensive encephalopathy); – neurasthenia (acrimony, fatigue, loss of ability to long intellectual and physical tension).

Route of administration and doses:

Inside on 2 tablets 2 times a day with an interval between receptions of 8-10 hours. It is necessary to take a pill not less than in 30 minutes prior to food, without chewing, washing down with water (100 ml). Administration of drug in morning and day time of day is recommended (no later than 18 hours). Duration of a course of treatment is 25 days. Purpose of a repeated course is possible with an interval not less than 1 month.

Features of use:

At an idiopathic hypertensia correction of doses of hypotensive drugs can be required. At patients with a diabetes mellitus to carry out treatment under control of concentration of glucose to blood. Perhaps intensive coloring of urine in yellow color. CYTOFLAVIN does not exert impact on: ability to manage vehicles, work with moving mechanisms, work of dispatchers and operators.

Side effects:

Headache, pains or discomfort in epigastric area. Allergic reactions in the form of a skin hyperemia and an itch are possible. Treat undesirable reactions: a tranzitorny hypoglycemia, a hyperuricemia, an exacerbation of the accompanying gout. If any of the side effects specified in the instruction are aggravated or you noticed any other side effects which are not specified in the instruction, report about it to the doctor.

Interaction with other medicines:

Succinic acid, inosine and niacinamide are compatible to other medicines. Riboflavinum reduces activity of some antibiotics (tetracyclines, erythromycin, lincomycin), is incompatible with streptomycin. Ethanol, tricyclic antidepressants, blockers of canalicular secretion reduce Riboflavinum absorption, and thyroid hormones accelerate his metabolism.

Contraindications:

Individual intolerance of components of drug. It is not recommended for use for children up to 18 years in connection with insufficiency of data on efficiency and safety.

Overdose:

So far overdose cases by the drug CYTOFLAVIN it was not established.

Storage conditions:

In the place protected from light at a temperature not over 25 ºС. To store in the place, unavailable to children. Period of validity 2 years. Not to use after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

The tablets covered with a kishechnorastvorimy cover. On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil for packaging or from the material combined on the basis of aluminum foil and aluminum foil for packaging. On 5 or 10 blister strip packagings together with the application instruction in a pack from a cardboard.