Tropisetron

General characteristics. Structure:

Active ingredient: 5 mg of a tropisetron (in the form of a tropisetron of a hydrochloride).

Has antiemetic effect.

Pharmacological properties:

Pharmacodynamics. Tropisetron prevents the nausea and vomiting caused by antineoplastic chemotherapy or surgical intervention, at the same time extrapyramidal side effects are not noted.

Duration of action of a tropisetron makes 24 hours that allows to apply its once in denpr carrying out repeated cycles of chemotherapy efficiency of drug remains.

Indications to use:

The prevention of nausea and vomiting, arising owing to antineoplastic chemotherapy.

Route of administration and doses:

Adults. трописетрон it is recommended to adults in the form of 6-day courses on 5 mg/days. In the first day appoint in/in, for a short period before use of antineoplastic chemotherapy: in the form of infusion (after preliminary cultivation), or in the form of a slow injection (not less than 1 min.).

If use of one tropisetron has insufficient antiemetic effect, the medical effect of drug can be strengthened by purpose of dexamethasone. In the capsule it is necessary to accept in the morning, washing down with water, at once after a rising, for 1 h before meal.

Children. At children the recommended dose of a tropisetron is more senior than 2 years makes 0,2 mg/kg; the maximum daily dose — to 5 mg. In the first day, for a short period before use of antineoplastic chemotherapy, it is recommended in/in introduction in the form of infusion (after preliminary cultivation). Then from the 2nd to the 5th day drug is appointed inside. Children with body weight have 25 kg and above the recommended daily dose for intake makes 5 mg.

Features of use:

Drivers of transport and people whose profession demands the increased concentration of attention and speed of psychomotor reactions should consider emergence of such effects as dizziness and increased fatigue.

Side effects:

At use of drug in the recommended doses undesirable effects have passing character. At use of a tropisetron the headache, a lock, dizziness, fatigue, abdominal pains, diarrhea are possible.

As well as in case of use of other antagonists of 5-HT3-receptors, hypersensitivity reactions ("reaction of the I type") which are characterized by one or several following symptoms are seldom observed: feeling of rush of blood to the person and/or a generalized small tortoiseshell, feeling of weight behind a breast, an asthma, sharply developing bronchospasm, arterial hypotension.

It was reported about very exceptional cases of a collapse, faint or cardiac standstill, but the causal relationship of these phenomena using a tropisetron was not established. Some of them could be caused by the accompanying therapy or a basic disease.

Interaction with other medicines:

Inductors of microsomal enzymes of a liver (rifampicin, phenobarbital) reduce concentration of a tropisetron in blood.

Therefore at patients who quickly metabolize трописетрон increase in doses (from patients who metabolize трописетрон slowly, it is not required) is necessary.

Influences of inhibitors of fermental system of P450 cytochrome, such as Cimetidinum, on levels of a tropisetron in plasma are insignificant; changes of a drug dosing in such cases are not required.

Researches of interaction of a tropisetron with anesthetics were not conducted.

Contraindications:

Hypersensitivity, pregnancy and lactation (it is necessary to stop breastfeeding for the period of treatment), children's age up to 2 years. 

Contraindicated during pregnancy. For the period of treatment it is necessary to stop breastfeeding.

Patients with uncontrollable arterial hypertension should avoid use of a tropisetron in the daily doses exceeding 10 mg as it can lead to further increase in arterial pressure. It is necessary to be careful to patients with disturbances of a cordial rhythm and conductivity, and also to patients to whom treatment is carried out by antiarrhytmic drugs or blockers of β-adrenoceptors..........

Overdose:

Symptoms: In case of repeated use of very high doses of a tropisetron visual hallucinations are possible; patients with the previous arterial hypertension have an increase in arterial pressure.

Treatment: The symptomatic treatment under constant control of the vital functions of an organism and condition of the patient is shown

Issue conditions:

According to the recipe

Packaging:

Capsules of 5 mg in a blister strip packaging No. 6.