The influenza vaccine inactivated elyuatno-centrifugal (influenza vaccine)

General characteristics. Structure:

Active ingredient: 10±1 mkg of hemagglutinin of virus strains of flu of a serotype _{of A (H1N1)}, 10±1 mkg of hemagglutinin of virus strains of flu of a serotype _{of A (H3N2)}, 13±1 mkg of hemagglutinin of virus strains of flu of a serotype of Century.

Excipients: albumine solution for инф. 10% and 20%, tiomersat.

Pharmacological properties:

Pharmacodynamics. The vaccine causes formation of specific immunity against an influenza virus of types A and B. The protective effect of a vaccine, as a rule, occurs in 3 weeks after vaccination and 10-12 months remain.

Indications to use:

— prevention of flu at adults is more senior than 18 years.

Route of administration and doses:

Inoculations carry out to the autumn and winter period. Annual vaccination is recommended first of all to persons with high risk of emergence of complications and to the persons by the nature of professions having high risk of a disease of flu or infections of other persons:

— persons are more senior than 60 years;

— the persons suffering from chronic somatopathies;

— often ill ORZ;

— health workers;

— workers of services industry, transport, educational institutions.

The vaccine is entered once, subcutaneously, in a dose of 0,5 ml, to the area of an outside surface of a shoulder is several centimeters lower than a shoulder joint.

Before use the ampoule with drug needs to be stirred up carefully.

Drug in ampoules with the broken integrity or marking is not suitable for use, at change of physical properties (color, transparency, homogeneity), at the expired period of validity, the wrong storage.

Opening of ampoules and the procedure of vaccination are carried out at strict observance of rules of an asepsis and antiseptics.

Drug in the opened ampoule is not subject to storage. The carried-out inoculation is registered in the established registration forms with the indication of Date of Introduction of drug, a dose, number of a series and the name of the manufacturing enterprise.

Features of use:

Use at pregnancy and feeding by a breast. It is contraindicated at pregnancy, in the period of a lactation.

Use for children. Apply at adults 18 years are more senior.

Use for elderly patients. Annual vaccination is recommended first of all to persons with high risk of emergence of complications and to the persons by the nature of professions having high risk of a disease of flu or infections of other persons, for example, persons are more senior than 60 years.

Special instructions. Precautionary measures at use. All persons which are subject to inoculations have to be inspected by the doctor taking into account anamnestic data. In day of an inoculation
vaccinated have to be examined by the doctor with obligatory thermometry. At a temperature above 37 °C vaccination is not carried out. The doctor is responsible for correctness of purpose of an inoculation.

After vaccination vaccinated has to be under medical observation not less than 30 min. The venue of inoculations has to be provided with means of antishock therapy.

Data on possible influence of medicine on ability to manage vehicles, mechanisms. Are not established.

Side effects:

At administration of drug at a part of vaccinated the general reactions in the form of an indisposition, a headache, fervescence can be observed. No more than 3% of reactions over 37,5 °C (including no more than 0,5% over 38,5 °C) registered in the first two days after immunization lasting not more than three days are allowed.

Local reactions (hyperemia and puffiness) arise at the majority of vaccinated; at a part of vaccinated limited infiltrates can be formed. Development of infiltrate up to 50 mm in size is allowed no more than in 3%. Duration of local reactions does not exceed 5 days.

Interaction with other medicines:

The influenza vaccine can be applied along with other vaccines of the National calendar of preventive inoculations and the inactivated vaccines of a calendar of the preventive inoculations according to epidemic indications entered by the adult. At the same time contraindications to each of the applied vaccines have to be considered, the drugs have to be administered in different body parts by different syringes.

Contraindications:

— allergic reactions to eggs and гиперчувствителыюсть to chicken protein;

— reaction or postvaccinal complication to the previous introduction of seasonal anti-influenza vaccines;

— acute infectious and noninfectious diseases, chronic diseases - inoculations carry out to aggravation stages not earlier than in a month after recovery (remission). At not heavy SARS, acute intestinal diseases vaccination is carried out after normalization of temperature;

— general diffusion diseases of connecting fabric;

— diseases of adrenal glands;

— hereditary, degenerative and progreduated diseases of a nervous system;

— pregnancy and lactation.

The possibility of vaccination of the persons having the chronic diseases which are not specified in the list of contraindications is defined by the attending physician, proceeding from a condition of the patient.

Overdose:

Cases of overdose are not established.

Storage conditions:

Store according to the joint venture 3.3.2.1248-03 at a temperature from 2 to 8 °C in the place, unavailable to children. Freezing is not allowed. A period of validity - 1 year.

Issue conditions:

According to the recipe

Packaging:

0.5 ml - ampoules (5) - planimetric strip packagings (2) - packs cardboard.
0.5 ml - ampoules (10) - boxes cardboard.
0.5 ml - syringes (1) - planimetric strip packagings (1) - packs cardboard.