Immunoglobulin anti-influenza person

General characteristics. Structure:

Active ingredients - specific antibodies-antigemaglyutininy in 1 ml of drug not less than 800 (AGE) of each etiologically urgent influenza strain And or In, or their combinations;

the stabilizer – glycine (glycine, the aminoacetic acid).

Main properties: drug is immunological the active protein fraction allocated from the blood plasma of the person cleared and concentrated by a fractionation method alcohol, which passed a stage of a virus inactivation solvent-detergentnym by method. Protein content in 1,0 ml of drug from 0,09 g to 0,11 g. Transparent or slightly opalescent, colourless or yellowish liquid. In the course of storage emergence of an insignificant deposit which disappears when stirring is possible. Drug contains antibodies to etiologically influenza strains, urgent for Ukraine, And (H3N2) or flu A (H1N1), or flu B not less than 800 antigemaglyutiniruyushchy units (AGE) in 1 ml. The list etiologically of strains, urgent for Ukraine, is revised before each epidemic season and will be coordinated with WHO recommendations. Drug does not contain preservative and antibiotics, in raw materials there are no antibodies to VICh-1, VICh-2, to a virus of hepatitis C and a surface antigen of a virus of hepatitis In (HBsAg).

Pharmacological properties:

The operating basis of drug are specific antibodies-antigemaglyutininy which concentration in blood at administration of immunoglobulin reaches a maximum in 24 hours. The elimination half-life of antibodies makes 4-5 weeks of an organism. Except specific action drug increases nonspecific resistance of an organism.

Indications to use:

Drug is used for prevention and treatment of flu. For increase in resistance of an organism, including in the period of reconvalescence after acute infections with a long current.

Route of administration and doses:

 Immunoglobulin is entered intramusculary.

For prevention and treatment of flu immunoglobulin is entered once - to children depending on age: up to 2 years - 1,0 ml, from 2nd to 7 years - 2 ml, to children of 7 years and adult - 3,0 ml. At treatment of severe forms of flu repeated introduction in the above-stated doses is recommended.

For increase in resistance of an organism in the period of reconvalescence after acute infectious diseases with a long current and at chronic and long pneumonia the drug is administered to adults and children in a single dose of 0,15 - 0,2 ml on 1 kg of body weight. The number of introductions (to 4 injections) is defined by the doctor, intervals between injections make 2-3 days.

After administration of immunoglobulin of an inoculation against measles and epidemic parotitis carry out not earlier than in 2-3 months. After vaccination against these infections immunoglobulin should be entered not earlier than in 2 weeks. In need of use of immunoglobulin before this term vaccination against measles or epidemic parotitis needs to be repeated. Other infections inoculations can be carried out to any terms to or after administration of immunoglobulin.

Features of use:

Administration of drug is intravenously forbidden!

Use during pregnancy and feeding by a breast. Long-term clinical experience of use of immunoglobulin indicates that it is not necessary to expect any harmful effects on mother and a fruit at pregnancy or on the newborn.

Immunoglobulin is emitted with breast milk and therefore can promote transfer of protective antibodys from mother to the child.

Side effects:

Reactions to administration of immunoglobulin, as a rule, are absent. In rare instances local reactions in the form of a hyperemia and temperature increase to ^{37,5 0C} within the first days can develop. At certain people with the changed reactivity allergic reactions of various type, and in exclusively exceptional cases - an acute anaphylaxis can develop. In this regard the persons who received drug have to be under medical observation within 30 minutes. Rooms of carrying out inoculations have to be provided with means of antishock therapy.

Interaction with other medicines:

In complex therapy it is combined with other groups of drugs.

Contraindications:

Administration of immunoglobulin is contraindicated to the persons having heavy allergic reactions to introduction of proteinaceous blood preparations of the person in the anamnesis. Or having a serious allergic illness in the anamnesis, in day of administration of immunoglobulin and in the next 3 days antihistaminic drugs are recommended to the patients having allergic diseases. To the persons suffering from immune general diseases (diseases of blood, connecting fabric, nephrite, etc.), it is necessary to enter immunoglobulin against the background of the corresponding therapy.

Overdose:

It was not studied.

Storage conditions:

In the dry, protected from light place at a temperature from 2 °C to 8 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

In ampoules on 1,0 ml (1 dose) and 2,0 ml (2 doses) on 3 or 10 ampoules in a box with a corrugated insert or with a polymeric insert from a film polyvinyl chloride for placement and fixing of ampoules.