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Abactal represents an antibiotic of a broad spectrum of activity. Concerning gram-positive, gram-negative microorganisms and intracellular activators Abactal has bactericidal effect.
Drug is produced in the form of tablets, coated, for oral administration and liquid for infusions.
Tablets from white till yellowish color biconvex an oval form, the containing 558,5 mg of a pefloksatsin of a mezilat of a dihydrate corresponding to 400 mg of a pefloksatsin.
Besides, each tablet as excipients contains:
The cover contains:
Tablets Abaktal on 10 pieces are packed into blisters which are packaged in individual cardboard packs.
The concentrate intended for production of solution for intravenous administration from yellow till light yellow color, transparent. In one ampoule – 400 mg of a pefloksatsin, in 1 ml – 80 mg.
As excipients solution contains:
Packaging on 10 ampoules, of 5 ml, in plastic pallets, one pallet in a cardboard pack.
Abaktal's use is reasonable at treatment and prevention of infectious diseases which are caused by bacteria, sensitive to action of a pefloksatsin.
According to the instruction to Abaktal it is used in a complex with other antimicrobic drugs or as means of monotherapy.
After oral administration Abaktal is absorbed in digestive tract. The maximum level in blood is observed in 1,5 hours. Extent of communication with proteins of plasma makes no more than 30% of the accepted dose. The medicine is metabolized in a liver, removed by the most part with urine and partially with bile both in the form of metabolites, and in an invariable look. After a single dose of Abaktal the elimination half-life makes 8 hours, and after repeated – 13 hours. It is possible to define existence of a pefloksatsin in urine within 3,5 days after the last use.
Often negative reviews of Abaktala are connected with the fact that precautionary measures at its use were broken.
Drug is contraindicated:
With care Abaktal appoint to people with organic lesions of TsNS, a heavy liver failure, disturbance of functions of a liver and kidneys.
Pill Abaktal should be taken inside in time or after food, washing down with enough water. They do not need to be crushed or divided. Abaktal's use will be more effective if to divide a daily dose into two parts and to use drug at regular intervals.
According to the instruction to Abaktal the necessary dose of drug makes:
At disturbance of functions of a liver Abaktal's use in the form of solution for infusions is recommended for what previously part contents of one ampoule in 250 ml of 5% of glucose. The received structure needs to be entered in slowly drop way. In order that therapeutic concentration of Abaktal were reached quicker, introduction in the first dose of 800 mg is admissible. The maximum daily dose of drug makes 1,2 g.
In surgery for prevention of infectious complications Abaktal's introduction is carried out in 1 hour prior to operation in a dose of 400-800 mg. Frequency of drop injection for patients with jaundice makes 1 time at 24 o'clock, with ascites – 1 time at 36 o'clock, with jaundice and ascites – is not more often than 1 time at 48 o'clock. To patients of advanced age, especially with disturbances of functions of kidneys, it is necessary to accept the reduced drug dose about what it is specified in the instruction to Abaktal.
Negative reaction to drug is possible from outside:
Developing of phlebitis, skin rash, erubescence, itch is also possible.
At Abaktal's use it is necessary to consider that:
Abaktal's drugs analogs on active active ingredient: Пелокс, Pefloksatsin, Peflotsin, Yunikpef, etc.
The period of validity of Abaktal makes 3 years. It is necessary to store drug in the place, unavailable to children, avoiding light hit, temperature indoors at the same time should not exceed 25 °C.
Name of drug
Abaktal of a tablet 400 of mg of 10 pieces
Abaktal тбл п / about 400 mg No. 10, Lek
Abaktal solution for injections 400mg/5ml 10 pieces
Abaktal solution for инъ 400 mg 5 ml No. 10, Lek
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