Agapurin

Agapurin is the medicine which is improving microblood circulation, having angioprotektorny and vasodilating effect. Drug is capable to reduce aggregation of erythrocytes and thrombocytes, to stimulate a fibrinolysis and to lead to decrease in fibrinogen in blood.

Form of release and structure

Agapurin on group accessory treats vazodilatiruyushchy means. The international name – Pentoxifylline.

Drug is produced in the form of tablets and a concentrate for preparation of injection solution.

The biconvex tablets covered with a white cover with glossy gloss contain 100 mg of a pentoksifillin and excipients:

• Lactoses monohydrate;
• Starch corn;
• Silicon colloid anhydrous;
• Talc;
• Magnesium stearate.

The cover consists of sodium of a karmelloza, sucrose crystal, sucrose powdery, talc, methylparaben, titanium of dioxide, silicon colloid anhydrous, acacia gum.

Agapurin Retard represents tablets of the prolonged action, the film coated, containing 400 mg or 600 mg of a pentoksifillin and additional substances:

• To Gipromelloz 2200/15000;
• Povidone 40;
• Talc;
• Magnesium stearate.

The composition of transparent, colourless solution for infusions includes 100 mg on 1 ampoule of a pentoksifillin, and also sodium chloride and water for injections.

Indications to use

The following is specified in the instruction to Agapurin among states at which use of this drug is reasonable:

• Disturbance of peripheric circulation against the background of atherosclerotic, diabetic and inflammatory processes;
• Deterioration in blood circulation of a brain at post-apoplectic and ischemic states;
• Disturbances of a trophicity of fabrics owing to a varicosity, freezing injury, gangrene, trophic ulcers of a shin, a posttrombotichesky syndrome;
• Cerebral atherosclerosis;
• Raynaud's disease;
• Virus neuroinfection;
• Distsirkulyatorny encephalopathy;
• Disturbance of blood circulation in a choroid and a retina of an eye;
• Coronary heart disease;
• State after the postponed myocardial infarction;
• Otosclerosis;
• Impotence of vascular genesis;
• Bronchial asthma;
• Chronic obstructive pulmonary disease.

Contraindications

Agapurin's use is contraindicated at the following diseases and states:

• Tendency to bleedings, retinal apoplexies, massive bleedings;
• Porphyria;
• Heavy arrhythmias;
• Acute hemorrhagic stroke, myocardial infarction;
• Severe form of atherosclerosis of coronary or cerebral vessels.

The children's age, the period of pregnancy and lactation, individual sensitivity to a pentoksifillin and other derivatives of methylxanthine are also the contraindications specified in the instruction to Agapurin.

Route of administration and dosage

Agapurin it is necessary to accept at the same time days after food, washing down with a large amount of water. Not to chew.

The initial dose makes 200 mg 3 times a day. If long therapy is necessary or bad portability of drug is observed, then the single dose decreases to 100 mg at preservation of number of receptions. The daily dose should not exceed 1200 mg.

Route of administration of Agapurin in the form of tablets with the prolonged action same, as well as tablets, coated; perhaps only reduction of frequency rate of administration of drug.

Agapurin in the form of solution for injections can be entered the next ways:

• Intramusculary. About 100 mg 1-2 times a day are usually entered, contents of an ampoule are not dissolved;
• Intravenously. According to the instruction to Agapurin, contents of an ampoule should be parted in 250-500 ml 0,9% of solution of sodium of chloride or 5% of solution of glucose. The drug has to be administered slowly, no more than 150 ml an hour. At good tolerance the daily dose increases to 2 ampoules (200 mg);
• Vnutriarterialno. Therapy begins with introduction of the contents of one ampoule dissolved in 20-50 ml of isotonic sodium of chloride within 10 minutes. At long treatment increase in a dose of drug up to 2-3 ampoules divorced in 30-50 ml of solution is possible.

The optimum dose of Agapurin is defined by the doctor individually for each patient.

Side effects

Agapurin can cause negative effects from outside:

• Nervous system – a sleep disorder, uneasiness, spasms, dizziness, headaches;
• The alimentary system – an intestines atony, cholestatic hepatitis, an exacerbation of cholecystitis, a loss of appetite, dryness in a mouth;
• Blood vessels and integuments – hypostases, a dermahemia of the person, rushes of blood to the person and an upper part of a thorax, fragility of nails;
• Cardiovascular system – a cardialgia, arrhythmia, tachycardia, a lowering of arterial pressure, progressing of stenocardia;
• Sense bodys – scotoma, a vision disorder;
• Systems of a hemostasis and bodies of a hemopoiesis – a leukopenia, a hypofibrinogenemia, thrombocytopenia, a pancytopenia, gastromenias, intestines, mucous membranes, hypodermic capillaries;
• Allergic reactions – urticaria, an itch, an acute anaphylaxis, a Quincke's disease.

Symptoms of overdose by Agapurin:

• Nausea;
• Dizziness;
• Tachycardia;
• Lowering of arterial pressure;
• Fever;
• Excitement;
• Loss of consciousness;
• Areflexia;
• Tonic and clonic spasms.

Special instructions

Reduction of a dose can be required by elderly people.

Smoking reduces a therapeutic effectiveness of Agapurin.

Analogs

Pentoksifillin is a part of a number of drugs:

• Vazonit;
• Pentilenum;
• Pentoksifillin;
• Trental;
• Fleksital.

Agapurin's analogs on the mechanism of action are:

• Xantinoli nicotinas;
• Teonicolum.

Terms and storage conditions

To store in the dry dark place, at a temperature not above 25 °C. To protect from children.

The period of validity of drug depends on a form of release and amount of active ingredient – from 3 to 5 years.