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Amikacin – antibacterial agent from group of aminoglycosides.
Amikacin is produced in the form of powder and ready solution for intramuscular and intravenous administration.
As active ingredient as a part of drug amikacin in the form of sulfate acts (1 ml – 250 mg). Auxiliary components are:
Solution of drug is produced in glass ampoules on 4 ml. The blister strip packaging contains 5 or 10 ampoules of means. In one cardboard pack 1 or 2 packagings.
Amikacin powder for preparation of solution is produced in bottles on 10 ml. One cardboard pack contains 1, 5 or 10 bottles.
According to the instruction, Amikacin is applied at:
According to the instruction, Amikacin is contraindicated at:
With care it is necessary to use an antibiotic at parkinsonism, a myasthenia, dehydration, during a lactation and at advanced age.
Besides, under strict medical control give Amikacin to newborn and premature children.
Intramusculary or intravenously Amikacin is entered by each 8 hours at the rate of 5 mg/kg or each 12 hours on 7,5 mg/kg.
At the uncomplicated bacterial infections which affected uric ways Amikacin use on 250 mg is shown each 12 hours.
To newborn premature children the drug begins to be administered in a dosage 10 mg/kg then pass 7,5 mg/kg which is entered by each 18-24 hours to a dose.
To healthy newborn children means enter 10 mg/kg then pass to 7,5 mg/kg each 12 hours for 7-10 days in an initial dose.
The most admissible daily dosage for adults – 15 mg/kg/days.
At intramuscular introduction therapy lasts 7-10 days, at intravenous – 3-7 days.
Amikacin in certain cases can cause the following side effects:
At use of Amikacin in the raised doses disturbance of an urination and breath, deterioration in hearing and appetite, an ataxy, dizziness, thirst, vomiting, a ring in ears is possible.
At poisoning with drug carry out peritoneal dialysis and a hemodialysis, artificial ventilation of the lungs, enter salts of calcium and antikholinesterazny drugs.
At intravenous use of Amikacin concentration of its active ingredient in solution should not exceed 5 mg/ml.
At treatment drug recommends at least 1 time in 7 days to control function of an acoustical nerve, kidneys and a vestibular mechanism.
At joint reception of Amikacin with benzylpenicillin effect of both drugs amplifies. Their combination at treatment of the infection caused by strains of a fecal enterokokk is especially effective.
Drug cannot be combined with heparin, penicillin, Amphotericinum In, kapreomitsiny, erythromycin, vitamins B and With, calcium chloride, a hydrochlorothiazide, cephalosporins.
Cisplatinum, Acidum nalidixicum, polymyxin B, Vancomycinum strengthen nefro-and ototoxicity of Amikacin.
In turn the antibiotic reduces efficiency of drugs against a myasthenia.
Amikacin analogs in the form of powder are drugs: Amikatsin-Vial, Amikatsin-Fereyn and Amikabol.
Act as means analogs in the form of solution: Selemitsin and Hematsin.
Amikacin needs to be stored in the dry, unavailable to children, protected from hit of direct sunshine place, at a temperature of 5-25 °C.
The period of validity makes 2 years.
Name of drug
Amikacin of 1000 mg n1 bottle (analysis)
Amikacin фл. 1000 mg of n1
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