Amlorus – a blocker of slow calcium channels, drug with anti-anginal and anti-hypertensive action.
Dosage form – tablets: a ploskotsilindrichesky form, almost white or white color (the mramornost is possible), with a facet (on 10 таб. in blister strip packagings, in a pack cardboard 3 packagings).
Active agent: амлодипин (in the form of a bezilat), in 1 tablet – 2,5, 5 or 10 mg.
Auxiliary components: cellulose microcrystallic, calcium stearate, silicon dioxide colloid (aerosil), кросповидон, lactoses monohydrate, talc.
Amlorus is applied as monodrug or as a part of a combination therapy (in a combination with hypotensive (arterial hypertension) or anti-anginal (vasospastic and stable stenocardias) means).
Amlorus it is necessary to accept inside, washing down with enough water, 1 time a day.
The initial dose at arterial hypertension and stenocardia makes 5 mg, in need of it increase up to 10 mg.
The supporting daily dose at arterial hypertension – 5 mg, at Printsmetal's stenocardia – 5-10 mg in 1 reception.
Decrease in an initial dose at arterial hypertension to 2,5 mg can be required by elderly people and patients with a liver failure.
Reduction of an initial dose is required to patients with the expressed abnormal liver functions, to patients of low growth and people with small body weight. To such patients as anti-anginal means Amlorus appoint 5 mg, as hypotensive – on 2,5 mg.
At co-administration of inhibitors of the angiotensin-converting enzyme (ACE), beta adrenoblockers or thiazide diuretics Amlorus's dose is not required to be adjusted.
At arterial hypertension Amlorus it is possible to combine with APF inhibitors, alpha and beta adrenoblockers, thiazide diuretics.
At stenocardia Amlorus can be appointed in a combination with other anti-anginal means, for example, beta adrenoblockers, nitrates of the short or prolonged action.
Amlodipin does not exert impact on plasma concentration of creatinine, uric acid, an urea nitrogen, triglycerides, lipoproteids of low density, the general cholesterol, glucose and potassium ions therefore it can be applied to treatment of patients with a diabetes mellitus, gout and bronchial asthma.
Amlorus it is possible to apply to therapy of the patients predisposed to vasoconstriction (a vascular spasm).
During treatment it is necessary to control body weight, to limit sodium consumption, to adhere to the diet appointed by the doctor, to be observed at the stomatologist (for prevention of bleeding, morbidity and a hyperplasia of gums), and also to be careful when driving the car and performing potentially dangerous types of works.
Amlodipin does not cause a withdrawal, nevertheless before its cancellation it is recommended to reduce a dose gradually.
At the use of grapefruit juice during treatment by Amlorus decrease in concentration of an amlodipin in a blood plasma is possible, however at a single dose of 240 mg of juice and 10 mg of an amlodipin essential changes of pharmacokinetics of drug are not noted.
To store in the place protected from light, dry and unavailable to children, at a temperature up to 25 °C.
Period of validity – 3 years.
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