The prices in Internet drugstores:
from 1900 rub.
Anfibra – anticoagulating drug.
Dosage form of release of Anfibra – solution for injections: transparent, with a yellowish shade or colourless (in ampoules on 0,2, 0,4, 0,6, 0,8 or 1 ml, in a cardboard pack 2, 5, 10 ampoules complete with an ampoule knife; in syringes on 0,2, 0,4, 0,6, 0,8 or 1 ml, on 2 syringes in blister strip packagings, in a cardboard pack of 1 or 5 packagings).
Composition of injection solution in 1 ampoule/syringe:
Relative (Anfibr is appointed with care at the following states / diseases):
To Anfibr enter subcutaneously, in inferiolateral / верхнебоковые parts of a front abdominal wall (alternately in left or right). Intramuscular introduction is contraindicated. The patient during an injection has to lie. The needle has to be directed vertically, it needs to be entered at all its length skin which is clamped pleated between two (index and big) fingers. Until the end of an injection the fold of skin is not straightened. The injection site after the procedure cannot be pounded.
The recommended dosing mode when performing prevention of venous thromboses and a thromboembolism (is defined by a risk degree of their development):
At transdermal coronary angioplasty, epidural/spinal anesthesia for the purpose of reduction of probability of bleeding it is better to establish/delete a catheter at low anticoagulating performance of an enoksaparin of sodium.
At prevention of a deep vein thrombosis establish/delete a catheter in 10-12 hours after Anfibra's introduction in preventive doses. In cases if the patient receives drug in higher doses (2 times a day on 1 mg/kg or once a day on 1,5 mg/kg), these procedures need to be postponed for 24 hours. The subsequent introduction of Anfibra is carried out not earlier, than in 2 hours after removal of a catheter.
At purpose of drug during epidural/spinal anesthesia constant careful control of a state for the purpose of identification of any symptoms of neurologic character is required (in the form of dorsodynias, disturbance of motor/touch functions, functional disturbances of intestines/bladder). In cases of emergence of symptoms of a hematoma of a brainstem carrying out urgent diagnosis and the treatment including, in case of need, carrying out a spinal decompression is required.
At prevention of venous thromboses and a thromboembolism at observing a bed rest sick Anfibra appoint 40 mg a course of 6-14 days once a day.
Treatment of a deep vein thrombosis (with/without thromboembolism of a pulmonary artery): once a day on 1,5 mg/kg or 2 times a day on 1 mg/kg, at the complicated thromboembolic disturbances – 2 times a day on 1 mg/kg. Use duration – 10 days. Therapy needs to be carried out in combination with peroral anticoagulants before achievement of necessary effect (INR (the international normalized relation) – 2-3).
At treatment of unstable stenocardia and myocardial infarction without tooth to Q Anfibr enter 2 times a day (with an interval of 12 hours) 1 mg/kg into combinations with ASK (on 100-325 mg once a day). The average duration of a course – 2-8 days (therapy will see to stabilization of a state).
Treatment of a myocardial infarction with raising of a segment of ST (it is medicamentous or by means of transdermal coronary intervention) it is necessary to begin 30 mg of an enoksaparin of sodium then (within 15 minutes) hypodermic introduction of 1 mg/kg of an enoksaparin of sodium is carried out with intravenous bolyusny administration (as much as possible when carrying out the first two subcutaneous injections it can be entered 100 mg of Anfibra). Then the drug is administered subcutaneously on 1 mg/kg by 2 times a day through equal intervals of time.
To patients 75 years initial intravenous bolyusny administration are more senior do not carry out. Enoksaparin of sodium is entered each 12 hours subcutaneously in a dose of 0,75 mg/kg (as much as possible when carrying out the first two subcutaneous injections it can be entered 75 mg of Anfibra). Then the drug is administered subcutaneously on 0,75 mg/kg by 2 times a day through equal intervals of time.
At the combined use from trombolitika (fibrin specific/nonspecific) эноксапарин sodium it is necessary to enter in the range from 15 minutes prior to thrombolytic therapy up to 30 minutes after it. In the minimum terms after detection of an acute myocardial infarction with raising of a segment of ST at the same time appoint ASK (therapy, in the absence of contraindications, carry out for not less than 30 days, daily 75-325 mg).
The recommended course duration – 8 days. Bolyusno solution is entered through the catheter established in a vein. It is impossible to mix / enter Anfibra along with other drugs (a catheter before introduction of an enoksaparin of sodium it is necessary to wash out 0,9% solution of sodium chloride or 5% dextrose solution, Anfibra's introduction with these solutions is authorized).
At treatment of an acute myocardial infarction with raising of a segment of ST for bolyusny administration of drug in a dose of 30 mg from glass syringes, big on volume, the excessive amount of solution is deleted so that in them there was the necessary dose. It can be entered intravenously.
At intravenous bolyusny administration of Anfibra through a venous catheter use of syringes of bigger volume is possible (on 60/80/100 mg). Use of syringes on 60 mg is recommended. Syringes of 20 mg in this case do not use because of the insufficient volume of drug, 40 mg – due to the lack of division and impossibility are correct to dose drug.
When carrying out transdermal coronary intervention, in cases if the last subcutaneous injection was carried out less than in 8 hours prior to inflating of the narrowing of a coronary artery of a balloon catheter entered into the place, additional introduction of Anfibra is not required. At a bigger break carry in addition out intravenous bolyusny administration in a dose of 0,3 mg/kg.
For the purpose of increase in accuracy of small volumes for bolyusny introduction to a venous catheter it is recommended to dissolve just before introduction drug to concentration of 3 mg/ml – by means of previously filled syringe of 60 mg it is necessary to use capacity from 0,9% solution of sodium chloride or 5% solution of a dextrose of 50 ml. From it by means of the ordinary syringe take and delete 30 ml of solution. Enoksaparin of sodium enter in remained in the volume of 20 ml of solution for infusions and carefully mix. The necessary volume of Anfibra needs to be taken by means of the syringe. Calculation is carried out as follows: volume of divorced drug = weight of the patient (kg) x 0,1.
At prevention of a thrombogenesis in system of artificial circulation when carrying out a hemodialysis drug is appointed at the rate of 1 mg to 1 kg of weight of the patient. In cases of existence of high probability of development of bleeding the dose is reduced: at double vascular access – for 50%, at unary – for 25%. At a hemodialysis Anfibr needs to enter at the beginning of the hemodialysis session into the arterial site of the shunt. As a rule, for a 4-hour session one dose, however in cases of detection of fibrinous rings suffices at more long hemodialysis perhaps additional introduction of a dose of 0,5-1 mg/kg.
For patients with a heavy renal failure the dose is adjusted: at clearance of creatinine it is less than 30 ml/min.: treatment – once a day on 1 mg/kg, prevention – once a day on 20 mg (the mode of dosing does not belong to hemodialysis cases). Dose adjustment at an easy/moderate renal failure is not required.
At elderly patients without renal failure correction of the mode of dosing is not carried out except treatment of a myocardial infarction with raising of a segment of ST.
It is less than 30 ml/min. of feature of dosing at clearance of endogenous creatinine (hypodermic introduction): 1 mg/kg 2 times a day or 1,5 mg/kg once a day (the usual mode)/1 mg/kg once a day (the mode at a renal failure in a heavy current).
Acute myocardial infarction with raising of a segment of ST (treatment of patients depending on age):
For prevention the following mode of dosing is shown: 20 or 40 mg once a day (the usual mode)/20 mg once a day (the mode at a renal failure in a heavy current).
Possible disturbances (≥1/10 – it is very frequent; ≥1/100-<1/10 – it is frequent; ≥1/1000-<1/100 – infrequently; ≥1/10 000-<1/1000 – it is rare; <1/10 000 – it is very rare):
The risk of the thrombocytopenia caused by heparin can remain for several years. In the presence of instructions on thrombocytopenia in the anamnesis Anfibra's appointment is possible only after consultation with the specialist. The developing thrombocytopenia is revealed, as a rule, during the period from 5 to 21 days from the moment of an initiation of treatment (regular control of quantity of thrombocytes is recommended to began treatment time). At the confirmed considerable decrease in number of thrombocytes (for 30-50% in comparison with an initial indicator) therapy is cancelled.
For reduction of the probability of bleeding connected with invasive vascular manipulation at therapy of unstable stenocardia and myocardial infarction without Q tooth, after hypodermic administration of drug it is not necessary to delete a catheter for 6-8 hours. The following dose can be entered after a break of 6-8 hours from the moment of removal of a catheter (observation of Anfibra injection site for the purpose of early detection of symptoms of bleeding and formation of a hematoma is shown).
There are data on exceptional cases of development of a hematoma of a spinal cord with the subsequent developing of irreversible/persistent paralysis at use of drug during spinal/epidural anesthesia. The probability of emergence of these phenomena decreases at Anfibra's use in a dose to 40 mg, increases – at increase in a dose, and also because of use of the getting epidural catheters during the postoperative period or at the combined use with medicines which influence a hemostasis. At emergence of symptoms, typical for a hematoma of a brainstem, appoint diagnosis and treatment.
Preventive appointment of Anfibra is justified in cases of development of an acute infection only at a combination of lengthening of the activated partial tromboplastinovy time and time of coagulation to such diseases / states as: hormonal therapy, age of 75 years, obesity, malignant new growths, anamnestic data on thromboembolisms/fibrinferments, heart/chronic respiratory failure.
It is not necessary to alternate Anfibra's use and other low-molecular heparins.
Anfibr cannot mix in one syringe with other substances / medicines.
At the combined use with such drugs as salicylates of systemic action, ASK, non-steroidal anti-inflammatory drugs, a dextrin with a molecular weight of 40 kd, klopidogret, тиклопидин, system glucocorticosteroids, trombolitik or anticoagulants, other antiagregantny drugs, increase in probability of emergence of bleedings is observed.
To store at a temperature up to 25 °C in protected from light and the place, unavailable to children.
Period of validity – 2 years.
Name of drug
Anfibra solution 10000ME anti-ha/ml 0,4ml 10 pieces
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