АнГриКапс maxim

АнГриКапс a maxim – drug for symptomatic therapy of acute respiratory viral diseases (SARS), the antiviral, febrifugal, anesthetizing, antihistaminic and angioprotektorny action.

Form of release and structure

Dosage form of drug – the capsule: No. 0, firm gelatinous, yellow color case and green color lid; contents – powder of color, light yellow with a cream or greenish shade (on 10 pieces in planimetric cell packagings / blisters, 2 packagings/blisters in a cardboard pack).

Contents of 1 capsule:

• active ingredients: paracetamol – 0,18 g, Rimantadinum a hydrochloride – 0,025 g, ascorbic acid (with a silicone SC covering) – 0,15 g, лоратадин – 0,0015 g, rutoside – 0,01 g, calcium a carbonate – 0,0112 g (in terms of calcium – 0,00448 g);
• auxiliary components: potato starch, calcium stearate, lactose;
• cover: gelatin pharmaceutical, methylparahydroxybenzoate, глицерол, пропилпарагидроксибензоат, titanium dioxide, sodium lauryl sulfate, the water purified dyes (A sunset yellow E-110, Quinolinic yellow E-104, Diamond blue E-133).

Indications to use

АнГриКапс a maxim apply to symptomatic and etiotropic treatment of an influenza virus And at children 14 years and adults are more senior. It is also recommended to use drug in the period of an epidemic season on flu for symptomatic therapy of the catarrhal diseases burdened by the following expressed grippopodobny symptoms: arthralgia, feverish syndrome, intoxication, headache.

Contraindications

Absolute:

• deficit of lactase, lactose intolerance, glyukozo-galaktozny malabsorption;
• period of pregnancy and lactation (breastfeeding);
• children's and teenage age up to 14 years;
• the increased individual sensitivity to one or several substances which are a part of drug.

Relative (medicine is taken with caution):

• renal and/or liver failure;
• nephrolithiasis;
• functional hyperbilirubinemias (including Gilbert's syndrome);
• viral hepatitis;
• alcoholic liver disease;
• epilepsy (including data in the anamnesis);
• sideroblastny anemias;
• advanced age.

Route of administration and dosage

Capsules of Angrikaps a maxim accept inside after meal, washing down with water.

The recommended dosing mode for children is more senior than 14 years and adult patients – on 2 capsules 2-3 times a day, a therapy course – 3-5 days (before removal of symptoms of a disease).

In case of lack of improvement reception of capsules it is necessary to stop and see consultation a doctor.

Side effects

• central nervous system: seldom – increased fatigue, a headache, hyper excitability, a tremor, dizziness, a hyperkinesia;
• digestive tract (if reception lasts more than 1 week): are possible – dryness in a mouth, dyspepsia, nausea, damage mucous a stomach and a 12-perstny gut, a meteorism, diarrhea, anorexia;
• system of blood (if reception lasts more than 1 week): are possible – a leukopenia, an agranulocytosis, thrombocytopenia, anemia, a neutropenia;
• hypersensitivity reactions: seldom – skin rash, a small tortoiseshell, an itch.

Can be overdose symptoms in the first days: nausea, pain in epigastriums, vomiting, pallor, drowsiness, a tremor, increase in bilirubin in blood, tachycardia, an exacerbation of the accompanying chronic diseases. Signs of disturbance of work of a liver can appear ^1/2-2 days later after overdose by the paracetamol which is a part of drug. As a result of heavy overdose are possible: pancreatitis, arrhythmia, an acute renal failure as a result of a tubular necrosis (including without severe damage of a liver), a liver failure with the progressing encephalopathy, a coma, death.

For therapy of a state it is necessary to cause an emetic reflex, to carry out a gastric lavage, to accept adsorbents and to carry out a symptomatic treatment then it is obligatory to see a doctor.

Special instructions

The maximum duration of therapy by drug of Angrikaps a maxim should not exceed 5 days. Long (over 7 days) use of capsules can cause an exacerbation of the accompanying chronic pathologies. At elderly patients in the presence of arterial hypertension the risk of development of a hemorrhagic stroke increases at the expense of Rimantadinum which is a part of medicine.

In the course of treatment it is required to refuse the drinks containing alcohol to reduce risk of gastrointestinal bleedings. At patients in the presence of an alcoholic hepatosis the probability of development of hepatic damages increases.

Paracetamol distorts data of laboratory researches of quantitative definition of uric acid and glucose in plasma.

As ascorbic acid has a promoting effect on synthesis of glucocorticosteroids, it is important to control the arterial pressure and function of adrenal glands. Vitamin C as a reducer, can change data of the following laboratory analyses: quantitative content in blood of bilirubin and glucose, indicators of activity of a lactate dehydrogenase and hepatic transaminases.

Maxim patients are forbidden to accept capsules of Angrikaps with the metastasizing tumors.

At occupations potentially dangerous types of activity (including driving of motor transport) demanding speed of psychomotor reactions and the increased concentration of attention it is necessary to be careful because of Rimantadinum which is contained in drug.

Medicinal interaction

• glucocorticoid drugs, gepatotoksichny and anticonvulsants, barbiturates, anticoagulants, rifampicin, alcohol – it is necessary to avoid whenever possible their combination with Angrikaps a maxim;
• diflunisat – increases concentration of paracetamol in plasma by 50%, increasing risk of development of a hepatotoxic of drug;
• miyelotoksikant – strengthen manifestation of a gematotoksichnost of paracetamol;
• Metoclopramidum – increases paracetamol absorption;
• benzylpenicillin and tetracyclines – ascorbic acid increases their concentration in blood;
• iron preparations – vitamin C improves their absorption in intestines, promoting transformation of trivalent iron in bivalent;
• salicylates and streptocides of short action – ascorbic acid increases risk of development of a crystalluria;
• acids – ascorbic acid slows down their removal by kidneys;
• drugs with alkali reaction, including alkaloids – ascorbic acid increases the speed of their removal;
• oral contraceptives – their concentration in blood decreases;
• antipsychotic medicines (neuroleptics), derivatives of a fenotiazin – their therapeutic action decreases;
• amphetamine and tricyclic antidepressants – decreases their canalicular reabsorption;
• CYP3A4 inhibitors (including erythromycin and кетоконазол), CYP3A4 and CYP2D6 inhibitors (Cimetidinum and so forth) – increase concentration in blood of a loratadin;
• rutoside – ascorbic acid strengthens its effect;
• tetracyclines, digoxin, peroral iron preparations – calcium the carbonate slows down their absorption (not less than 2 hours are required to observe an interval between their receptions);
• thiazide diuretics – can strengthen a hypercalcemia, reduce effect of a calcitonin owing to a hypercalcemia, underestimate bioavailability of Phenytoinum.

In case of need reception of Angrikaps the maxim together with other medicines is required to consult with the doctor in advance.

Terms and storage conditions

To store in the dry, dark place at a temperature not above 15-25 °C. To protect from children.

Period of validity – 2 years.