Antabusum – the drug causing the following negative effects in combination with alcohol: nausea, vomiting, "inflows" of blood to the person, tachycardia, hypotonia, etc.; alcohol intake after its reception is extremely unpleasant that creates conditioned-reflex disgust for a smell and taste of alcoholic drinks.
Dosage form of Antabusum – a tablet sparkling: almost white or white color, round, flat, with slanted edges:
Sparkling contain in 1 tablet:
Drug is shown for therapy and prevention of a recurrence of an alcoholism.
Relative: Antabusum is applied with care at a diabetes mellitus, a hypothyroidism, signs of an irreversible damage of a brain, a renal failure, diseases of respiratory system or a liver, epilepsy or a convulsive syndrome of any genesis (the probability Disulfiramum - ethanol reaction in heavier degree), peripheral neuropathy, a peptic ulcer of a stomach and a 12-perstny gut, an optic neuritis, and also at advanced age (after 60 years is increased).
The sparkling pill Antabusum is taken inside, previously having dissolved in water (1/2 glasses).
Drug is used only under observation of the doctor. Therapy is appointed after careful clinical inspection of the patient and the warning of abstention from alcohol intake for the period of treatment, and also possible complications and effects.
Drug is accepted according to the individual scheme determined by the attending physician at the rate of 0,2-0,5 g by 1-2 times a day.
7-10 days later from the beginning of therapy it is necessary to carry out Disulfiramum - alcoholic test. For this purpose the patient is given 20-30 ml of vodka after reception of 0,5 g of drug if reaction weak, the dose of alcohol is increased to 30-50 ml (the most admissible dose of vodka – 100-120 ml). In 1-2 days test is repeated in the conditions of a hospital, after 3-5 days – it is out-patient, as necessary adjust doses of alcohol and/or drug. Further Antabusum is allowed to use in a maintenance dose 0,15-0,2 g/days for 1-3 years.
Nonspecific side effects, the most often observable at reception of Antabusum which, including, can be connected with a basic disease: a headache, drowsiness, reactions from the digestive tract (DT). At their manifestation, perhaps, it will be required to reduce a drug dose.
Frequency of undesirable reactions from bodies and systems (according to the following classification –> 1/10 – it is very frequent,> 1/100-<1/10 – often,> 1/1000-<1/100 – infrequently,> 1/10 000-<1/1000 – seldom, <1/10 000, including isolated cases – it is very rare, frequency is unknown):
The side reactions which are possibly arising owing to combined use of Disulfiramum and ethanol:
Result of overdose of a combination ethanol Disulfiramum can be a cardiovascular collapse, consciousness oppression (up to a coma), neurologic complications. In such situation symptomatic therapy is carried out.
Patients are required to be warned about danger of reaction of intolerance of alcoholic beverages.
At co-administration of Antabusum with peroral anticoagulants more frequent control of maintenance of a prothrombin and correction of doses of anticoagulants is necessary, it is connected with the increased probability of development of bleeding.
Patients with a hypothyroidism or a renal failure take Disulfiramum with caution, especially at risk of its possible combination to alcohol.
The side reactions caused by reception of Disulfiramum (including fatigue and drowsiness), exert impact on speed of psychomotor reactions and ability to concentration of attention. In case of such states during therapy by the drug Antabusum from control of difficult mechanisms and vehicles, including the car, it is required to abstain.
Ascorbic acid reduces reaction of Disulfiramum to ethanol.
Contraindicated combined use of Antabusum and alcohol (the alcoholic drinks and medicines containing alcohol) as it can cause the reactions of intolerance which are followed by blood "inflows", an erythema, vomiting, tachycardia.
Others the undesirable and demanding care combinations with Disulfiramum:
When above-mentioned combinations cannot be avoided, in the course of therapy and after treatment by Antabusum control of concentration of drug in plasma and regular clinical observation of patients is necessary.
To store at a temperature not above 30 °C. To protect from children.
Period of validity – 5 years.
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