Atropine – cholinolytic drug, a m-holinoretseptorov blocker.
Atropine is produced in the following forms:
Atropine is anticholinergic and an antispasmodic. Its active agent – poisonous alkaloid which contains in leaves and seeds of plants of family of a nightshade family, such as a henbane, a belladonna, a dope. The main chemical feature of drug consists in its ability to block m-holinoreaktivnye of system of an organism which are located in a cardiac muscle, bodies with smooth muscles, the central nervous system and secretory glands.
Use of Atropine promotes reduction of secretory function of glands, relaxation of a tone of smooth muscle bodies, a mydriasis, increase in intraocular pressure and paralysis of accommodation (ability of an eye to change focal length). Acceleration and initiation of cordial activity after use of medicine is explained by its ability to remove the braking influences of a vagus nerve. Influence of drug on the central nervous system happens in the form of stimulation of a respiratory center, and when using toxic doses perhaps motive and a hyperphrenia (spasms, visual hallucinations).
Atropine is appointed:
Also Atropine is applied when carrying out X-ray inspections of digestive tract, to premedication before surgeries and in ophthalmology (to a mydriasis and achievement of paralysis of accommodation for the purpose of definition of a true refraction of an eye, a research of an eyeground, treatment of a spasm of the central artery of a retina, a keratitis, an iritis, a choroiditis, an iridocyclitis, an embolism and some injuries of an eye).
Use of Atropine is contraindicated at hypersensitivity to the components which are a part of drug.
Solution for injections
Depending on indications Atropine is entered subcutaneously, intramusculary or intravenously on 0,25-1 mg, frequency rate of use – to 2 times a day.
The adult for elimination of bradycardia intravenously enter 0,5-1 mg, if necessary in 5 minutes repeat administration of drug. The children's dosage is defined by body weight – 0,01 mg/kg.
For premedication Atropine is entered intramusculary in 45-60 minutes prior to anesthesia:
At use of Atropine in ophthalmology 1-2 drops of 1% of solution dig in in a sore eye, frequency rate of use (is defined by indications) – up to 3 times a day with observance of an interval of 5-6 hours. Introduction of 0,1% of solution is in certain cases possible:
For an electrophoresis enter 0,5% Atropine solution from the anode through eyelids.
At system use of Atropine can develop:
At use of Atropine at treatment of eye diseases in certain cases can arise:
Atropine should be applied with care at diseases of cardiovascular system at which increase in heart rate is undesirable:
Also Atropine needs to be applied with care at a thyrotoxicosis, acute bleeding, a reflux esophagitis, the increased body temperature, increase in intraocular pressure, diseases of digestive tract which are followed by impassability, a gestosis, dryness in a mouth, nonspecific ulcer colitis, chronic diseases of lungs, a liver and renal failure, a prostatauxe without obstruction of urinary tract, a myasthenia, cerebral palsy, injury of a brain at children, a Down syndrome.
It is necessary to observe an interval not less than 1 hour between use of antiacid drugs and Atropine.
At parabulbar or subconjunctival administration of drug for the purpose of reduction of tachycardia the patient needs to give Tabulettae Validoli under language.
During treatment by Atropine it is necessary to be careful at occupations potentially dangerous types of activity and when driving motor transport.
On the action mechanism analogs of Atropine are: Bellatsekhol, Appamid Plus, Cyclohoney, Tropikamid, Giostsiamin, Midriatsil, Tsikloptik, Midrimaks, Becarbonum.
Drug is released according to the recipe of the doctor. The Atropine period of validity at a temperature up to 25 °C makes:
The 74-year-old resident of Australia James Harrison became blood donor about 1000 times. It has a rare blood group which antibodies help to survive the newborn with a severe form of anemia. Thus, the Australian saved about two million children.
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