Dona

Dona – the drug regulating exchange processes in cartilaginous tissue.

Form of release and structure

Don is let out in the following dosage forms:

• Tablets, film coated: white, oblong; on cross section two layers: outside – white color, internal – color, white with a brownish shade (in polyethylene bottles on 60 or 180 pieces, on 1 bottle in a cardboard pack);
• Powder for preparation of solution for intake (in bags on 1500 mg, on 20 or 30 bags in a cardboard pack);
• Solution for intramuscular introduction (in dark glass ampoules on 2 ml, on 6 ampoules in a cardboard pack complete with solvent).

Is a part of 1 tablet:

• Active agent: a glycosamine – 750 mg (in the form of sulfate);
• Auxiliary components: macrogoal 6000, microcrystallic cellulose, K25 povidone, magnesium stearate, croscarmellose sodium, talc.

Structure of a film cover: copolymer (1:1) methylmethacrylates and methacrylic acid (Eudragit of L 12,5), the crushed titanium dioxide, talc, triacetin, copolymer (2:1:0,2) methylmethacrylate, ethyl acrylate and a trimetilammonioetilmetakrilat of chloride (Eudragit of RL 30 D), a macrogoal 6000.

For preparation of solution for intake is a part of 1 bag of powder:

• Active agent: a glycosamine – 1500 mg (in the form of sulfate);
• Auxiliary components: citric acid, sodium chloride, sorbitol, aspartame, carbowax 4000.

For intramuscular introduction is a part of 1 ml of solution:

• Active agent: a glycosamine – 200 mg (in the form of sulfate);
• Auxiliary components: sodium chloride, a lidocaine hydrochloride, water for injections.

Solvent: diethanol amide, water for injections.

Indications to use

• Osteoarthritis (primary and secondary);
• Spondylarthrosis;
• Osteochondrosis.

Contraindications

• Age up to 12 years;
• Pregnancy and period of a lactation;
• Hypersensitivity to drug components.

Don should be applied with care to patients with an allergy to seafood (mollusks, shrimps).

In addition it is contraindicated to use drug at the following diseases:

• Tablets: heavy chronic renal failure;
• Solution for intravenous injections: an acute heart failure, disturbances of cordial conductivity, heavy functional disturbances of kidneys and a liver, epileptiform spasms in the anamnesis.

Don in the form of solution should be applied to injections with care the patient with arterial hypotonia and chronic heart failure.

Route of administration and dosage

The scheme and duration of treatment is defined by the doctor.

Don in the form of tablets is accepted inside, washing down with a glass of water, it is desirable during food.

Usually appoint 2 times a day on 1 tablet (750 mg) or once a day on 1 bag (1500 mg). The symptomatic effect occurs in 14-21 days from the moment of the beginning of therapy. The minimum duration of a medical course – 4-6 weeks. If necessary at an interval of the 2nd month the course can be repeated.

Don in the form of solution for injections is entered only intramusculary (drug is not intended for intravenous administration). Before use solution of drug should be mixed in one syringe with solvent. The received volume (3 ml) is entered intramusculary (frequency rate –3 times a week). Therapy duration – 4-6 weeks. Injections can be combined with Dona's reception inside.

Side effects

As a rule, Dona is had well.

In some cases during therapy the meteorism, a gastralgia, diarrhea, nausea, a lock, drowsiness, a headache, allergic reactions can develop (in the form of an erythema, urticaria and an itch).

At Dona's use in the form of solution for injections, because of the lidocaine which is its part, development of nausea, vomiting, drowsiness, a diplopia, dizziness, headache, numbness of a mucous membrane of a mouth and language, a tremor, disorientation, euphoria, disturbances of cordial conductivity is possible.

Special instructions

Sodium is a part of tablets that should be considered the patient keeping to a controlled sodium diet.

At Dona's use for patients with the expressed renal and liver failure and also broken by tolerance of glucose medical control is necessary.

With caution it is necessary to take drug at a diabetes mellitus and bronchial asthma.

Medicinal interaction

Don can be applied along with non-steroidal anti-inflammatory drugs, glucocorticosteroids and paracetamol. Drug reduces absorption of chloramphenicol and semi-synthetic penicillin, increases – tetracyclines, and also strengthens effect of effect of coumarinic anticoagulants.

It is necessary to be careful at purpose of injections of Dona along with digitoxin, beta adrenoblockers, amnodarony, Ajmalinum, verapamil, novokainamidy, quinidine, thiopental or hexenal of sodium, monoamine oxidase inhibitors, Cimetidinum, polimiksinom-V, sedative or hypnagogues.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 25 °C.

Period of validity:

• Tablets and powder for preparation of solution for intake – 3 years;
• Solution for intramuscular introduction – 2 years.