Phenazepamum

Pharmacological action

Phenazepamum – a highly active tranquilizer, renders anxiolytic, anticonvulsant, myorelaxation and sedative action is central. The tranquilizing and antialarming effect surpasses Phenazepamum analogs in force. Also drug has anticonvulsant and somnolent effect. The anxiolytic effect of drug is expressed in decrease in emotional pressure, weakening of fear, alarm and concern.

On the received comments Phenazepamum practically does not exert impact on affective, hallucinatory and acute crazy frustration.

Dosage Phenazepamum and application instruction

Intramusculary and intravenously: for bystry stopping of psychomotor excitement, alarm, fear, and also at psychotic states and vegetative paroxysms – an initial dose to 1 mg, an average dose during a day of –3-5 mg, maximum – 7-9 mg.

Oral administration: at sleep disorders, from 250 to 500 mkg, in 20-30 minutes before going to bed. At therapy of psychopathic, neurotic, psychosimilar and neurosis-like states, the first dose to 1 mg, 2-3 times a day. The dosage can be increased in 2-4 days, with positive effect, to 4-6 mg a day. At the expressed fear, agitation, uneasiness of a pervayadoz 3 mg a day, with bystry building before achievement of therapeutic effect make. At therapy of epilepsy of 2-10 mg a day. At treatment of diseases with a muscle hyper tone accept 2-3 mg of drug 1-2 times a day. The maximum dose – 10 mg/days.

In order to avoid acquisition of dependence on Phenazepamum the instruction recommends that the course of therapy did not last more than two weeks. Increase in duration of a course up to 2 months is in exceptional cases possible. Decrease in a dosage has to happen gradually.

Indications to use of Phenazepamum

Phenazepamum is shown at neurotic, neurosis-like, psychopathic and psychosimilar states. At reactive psychoses, senesto-hypochiondrial frustration, sleeplessness, alcoholism, toxicomania, the epileptic status, epileptic seizures.

It is recommended as means for overcoming fear and emotional pressure in extreme situations. At schizophrenia, with high sensitivity to antipsychotic medicines.

For therapy of muscle tension, hyperkinesias, athetosis, tic, vegetative lability.

Contraindications to use of Phenazepamum

• coma;
• myasthenia;
• shock;
• severe form of a depression;
• closed-angle glaucoma;
• poisonings with analgetics or acute alcoholic poisoning;
• acute respiratory insufficiency;
• I trimester of pregnancy;
• to children up to 18 years;
• at a lactation;
• intolerance of benzodiazepines.

Special instructions

Patients need care at use of Phenazepamum with a liver or renal failure, to persons inclined to abuse of psychoactive agents, at organic injuries of a brain, to patients of advanced age.

Like analogs, Phenazepamum can cause medicinal dependence at long therapy by high doses. When performing treatment Phenazepamum strictly forbade the ethanol use. About treatment of persons under 18 Phenazepamum there are no responses, efficiency and safety of drug is not established. Phenazepamum exerts impact on concentration of attention therefore the persons receiving treatment by Phenazepamum need extra care when driving transport.

Overdose by Phenazepamum

Overdose symptoms Phenazepamum: decrease in reflexes, drowsiness, a tremor, a nystagmus, a long dysarthtia, an asthma or the complicated breath, bradycardia, a coma, a lowering of arterial pressure.

For overdose treatment Phenazepamum recommends reception of absorbent carbon, a gastric lavage, introduction of a flumazenil (in a hospital). The hemodialysis — is ineffective.

Interaction of Phenazepamum with other drugs

According to responses Phenazepamum renders decrease in efficiency of a levodopa at patients with Parkinson's disease. Phenazepamum increases toxicity of a zidovudine.

Mutual strengthening of effect at a combination is noted with antipsychotic, antiepileptic and hypnagogues, and also with the central muscle relaxants, narcotic analgetics and ethanol.

At a combination to anti-hypertensive means perhaps strengthenings of their action. At a concomitant use of clozapine respiratory depression is possible.

Pregnancy and lactation

Use of Phenazepamum by pregnant women is admissible only on vital indicators. Drug makes toxic impact on a fruit, increasing danger of development of inborn defects, when using in the 1st trimester of pregnancy. Use of Phenazepamum on later terms causes oppression of the central nervous system in the newborn. Regular inclusion in time of pregnancy can develop dependence and a withdrawal at the newborn.

Use of Phenazepamum at the time of delivery, or just before them, can be the cause of emergence in the newborn: oppressed breath, hypothermia and hypotonia.

Side effects of Phenazepamum

From the central and peripheral nervous system: in the first days of reception (especially at elderly patients) – feeling of fatigue, confusion of consciousness, drowsiness, dizziness, an ataxy, decrease in concentration of attention, a disorientation, delay of reactions; seldom – a depression, euphoria, a headache, a tremor, an incoordination, a memory impairment, the uncontrollable movements, an adynamy, a dysarthtia, a myasthenia, epileptic seizures (at patients with epilepsy); extremely seldom – aggressive flashes, fear, psychomotor excitement, suicide bents, spasms of muscles, hallucinations, irritability, excitement, sleeplessness, uneasiness.

From the blood circulatory system: leukopenia, agranulocytosis, neutropenia, thrombocytopenia, anemia.

From the alimentary system: heartburn, vomiting, diarrhea or locks.

Allergic reactions in the form of an itch or skin rashes are possible.

Other possible reactions: as well as its analogs, Phenazepamum are caused by emergence of medicinal dependence, a lowering of arterial pressure; seldom – a vision disorder, tachycardia. At sharp cancellation or a dose decline - emergence of a withdrawal.