Hydrocortisone

The hydrocortisone is a hormonal drug of the steroid nature which is produced by bark of adrenal glands and takes part in carbohydrate and protein metabolism.

Pharmacological group – glucocorticosteroids.

Dosage form

Drug is produced in the following forms:

• oculentum Hydrocortisone;
• drops eye Hydrocortisone;
• Hydrocortisone suspension for intramuscular and intra joint injections;
• powder for preparation of injections;
• Tablets Hydrocortisone;
• Hydrocortisone ointment;

Active ingredient

Hydrocortisone

Pharmacological action

The drug Hydrocortisone is a synthetic glucocorticosteroid means for system and topical administration, with expressed high-speed antiinflammatory, the anti-exudative (antiedematous), desensibilizing (antiallergenic) immunodepressive, antishock and anti-toxic effect.

The hydrocortisone through a certain reaction chain slows down release of mediators of an inflammation. The immunodepressive effect of drug is caused by braking of reactions of immune system.

Indications to use of the Hydrocortisone

For external use of the Hydrocortisone use the Hydrocortisone ointment at not infected superficial skin surfaces.

For topical administration use eye drops and an oculentum the Hydrocortisone at inflammatory processes in an anterior chamber of an eye without damages of a cornea:

• uveitis;
• keratitis;
• iridocyclitis;
• blepharitis;
• allergic conjunctivitis, etc.

Periartikulyarno or vnutrisustavno (Hydrocortisone acetate in suspension):

• posttraumatic osteoarthrites;
• syndrome of a carpal tunnel;
• nonspecific tendosinovita;
• pseudorheumatism;
• epicondylitis;
• subacute and acute bursitis;
• reactive synovitis.

Intradermal injections (hydrocortisone acetate in suspension):

• toxidermia;
• lupus erythematosus;
• atopic dermatitis (neurodermatitis);
• ring-shaped granuloma;
• flat deprive, etc.

System therapy (inside, in oil, in/in) the Hydrocortisone suspension, tablets, powder for preparation of injections:

• endocrine disturbances - a hypercalcemia, as a result of tumoral to process,
• thyroiditis not purulent (thyrocardiac crisis), adrenal struma (inborn), epinephral insufficiency;
• acute states allergic reactions;
• medical emergencies;
• collagenoses;
• skin diseases;
• respiratory diseases, such as respiration pneumonitis (with - m of Mendelssohn), etc.
• hematologic diseases: hypoplastic anemia (inborn), eritroblastopeniya, secondary thrombocytopenia, autoimmune anemia;
• gastrointestinal diseases:. Krone (in complex therapy);
• meningitis tubercular (in a complex with antitubercular chemotherapy);
• trichinosis with damage of a myocardium or a nervous system;
• multiple sclerosis;
• poisonings with chlorine, organophosphorous substances, vitamin D, quinine, acids, at stings of snakes, spiders and insects.

Contraindications to use of the Hydrocortisone

At outside and local purpose of the Hydrocortisone:

• children up to 2 years,
• individual hypersensitivity to drug;
• the short period after vaccination;
• at disturbances of integrity of a cover of skin (ulcer, crack, wound) and eye epithelium;
• viral, fungus and bacterial diseases of eyes and skin;
• dermatitis near a mouth;
• vulgar eels of acne vulgaris;
• localization on a face of Pink eels;

With care to recognize in cases: pregnancies (the I trimester) and lactations, systemic lesion at tuberculosis, a diabetes mellitus.

At system therapy care is required by the Hydrocortisone at:

• severe forms of arterial hypertension;
• Icenco-Cushing syndrome;
• round ulcers;
• diverticulitis;
• osteoporosis;
• postoperative period;
• fungus diseases;
• period of a lactation and pregnancy;
• acute endocarditis;
• nephrite;
• renal failure;
• tendency to thromboembolisms;
• herpetic fever;
• the previous arthroplasty;
• AIDS, HIV infection;
• myasthenia;
• individual hypersensitivity to drug.

Side effects

According to the instruction to the Hydrocortisone at use of the Hydrocortisone are possible emergence of some undesirable side effects.

At topical administration allergies, burning, an injektsirovaniye of vessels of scleras can develop; In case of prolonged use of Gidrokorizon of drops or an oculentum Gidrokorizon, development of a subkapsulyarny cataract, glaucoma or exophthalmos is possible;

At external use there can be skin allergic reactions.

Local and cumulative system side effects arise in case of prolonged use of the Hydrocortisone on very big surfaces or in places of the injured skin and also when use the Hydrocortisone ointment under occlusive bandages.

At use of the Hydrocortisone for system therapy the following side effects are possible:

From endocrine system:

• decrease in carbohydrate tolerance;
• hyperglycemia up to a diabetes mellitus;
• need for increase in a dose of insulin or other gipoglikemiziruyushchy means at diabetics;
• growth inhibition at children;
• Icenco-Cushing syndrome;
• pituitary and epinephral insufficiency;
• dysmenorrhea;
• hirsutism;
• hormonal obesity;
• atrophy a cow of a part of adrenal glands – in case of prolonged use of the Hydrocortisone

From a musculoskeletal system:

• osteoporosis with pathological changes, compression break vertebrae;
• aseptic necroses of heads of humeral and femoral bones;
• arthropathy;
• arthralgia;
• steroid myopathy;

From a GIT:

• perforation of a gut;
• gastric bleeding;
• round ulcers;
• pancreatitis;
• dyspepsia;
• esophagitis.

From integuments and mucous:

• deterioration in healing of wounds,
• allergic reactions
• skin discoloration

From TsNS and organs of sight:

• mental disturbances;
• subkapsulyarny cataract;
• glaucoma;
• increase in intracranial pressure.

Other side effects: immunodepressive states, disturbance of water and electrolytic exchange, increase in the ABP, vasculitis.

Application instruction of the Hydrocortisone

At medical emergencies recommend to apply the Hydrocortisone intravenously.

The dose of adults begins from 100 ml to 450-500 ml and more, depending on weight of a condition of the patient. Appoint up to 1500 mg/days.

In oil vzrosly - 125-200mg in days

To children - 15-30 mg a day, having divided a dose into several receptions.

Vnutrisustavno and periartikulyarno enter the Hydrocortisone into suspensions:

• the adult on 3-50 mg;
• to children on 25 mg - from 3 months to 1 year; on 25-50 mg – from 1 to 6 years; on 50-75 mg – with 6 do14 years.

The oculentum the Hydrocortisone is entered into a conjunctival sac on 1, 2 or 3 times a day.

Ointment the Hydrocortisone is applied by a thin layer on skin not more often than four times a day, the course of treatment makes no more than three weeks.

According to the instruction to the Hydrocortisone, the initial dose for intake makes 20-240ml, with the subsequent its decrease. But, at an exacerbation of multiple sclerosis, it is possible to increase a dose to 800 mg in days, with the subsequent decrease.

Storage conditions

To store at the room temperature.