Ethambutolum
Application instruction:
Ethambutolum represents antitubercular drug which is effective for treatment of tuberculosis at various stages of a current. Drug renders the bacteriostatic, antimicrobic, healing and antiinflammatory action.
Ethambutolum is appointed both in monotherapy, and in complex treatment of diseases of respiratory system.
Structure and form of release
The main active ingredient – Ethambutolum of 0,4 g.
Auxiliary components: ethylene, talc, propylene glycol, food dye.
Ethambutolum is issued in tablets on 0,4 g placed in cardboard packaging on 50-100 pieces.
Pharmacological properties of Ethambutolum
Ethambutolum actively gets into cells of mycobacteria, interferes with their reproduction and development, and also breaks cellular metabolism and destroys infections in respiratory tracts. Drug is effective for elimination of a streptococcus, staphylococcus and Mycobacterium tuberculosis. Ethambutolum destroys even bacteria which are steady against influence of other antitubercular drugs.
After administration of drug the medical effect is reached within a day. Ethambutolum is soaked up for 80% and reaches the maximum concentration in a blood plasma within 24 hours. Concentration in lungs is more, than concentration in blood, by 6-8 times. Drug creates several metabolites of inactive action which are brought out of an organism by kidneys with urine and excrements.
Indications to use
Ethambutolum is appointed for treatment of tuberculosis at various stages of a current and a serious illness of respiratory system.
Application instruction of Ethambutolum
According to the instruction Ethambutolum is appointed to accept after food of 1 times a day 15 mg. The dosage of drug can be increased to 25-50 mg 2 times a day (depending on a tuberculosis stage). The course of treatment lasts 2-3 months.
After a basic course of treatment within 2-3 weeks the maintenance dose of drug – 10 mg of 1 times a day is appointed.
The maximum daily dose of Ethambutolum for adults should not be more than 2 g. Children should not appoint drug up to 13 years, and from 13 years the dosage makes 15 mg 1-2 times a day. The daily dose for children should not exceed 1 g.
The general course of treatment of tuberculosis at a heavy stage of a current lasts from 9 months to 2 years.
According to the instruction patients should not appoint Ethambutolum with disturbances of functioning of a liver and kidneys, and at a serious illness of heart and bodies of a GIT the minimum dosage of drug is appointed.
During a course of treatment it is regularly necessary to conduct ophthalmologic examination, to control functioning of cardiovascular and nervous systems.
Contraindications
Contraindications to purpose of Ethambutolum are hypersensitivity and intolerance of components of drug, a vision disorder and a cataract, inflammatory diseases of eyes, a diabetes mellitus, a renal and liver failure, pregnancy and the period of breastfeeding, children's age up to 13 years.
With caution drug should be taken to the patients managing vehicles and working at dangerous objects. Ethambutolum can reduce concentration of attention and cause block.
Side effects of Ethambutolum
Local side effects of Ethambutolum: skin rash, itch, burning, dermahemia, small tortoiseshell, dermatitis.
Systemic side effects: depression, anorexia, headache and dizziness, disorientation, hallucinations, atrophy of an optic nerve, decrease in visual acuity, dispepsichesky disorders, disturbances of functioning of a liver and kidneys, leukopenia, arthralgia.
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