Etazolum

Etazolum – antibacterial drug for system use at treatment of infections of skin, ENT organs and respiratory tracts.

Pharmacological action of Etazolum

Active component of Etazolum has antibacterial activity concerning pneumococci, streptococci, gonokokk, meningokokk, the causative agent of dysentery, colibacillus, and also causative anaerobic microorganisms.

Etazolum according to the instruction малотоксичен and, as a rule, is well transferred by patients.

Release form

Etazolum is released in three dosage forms:

• Tablets on 250 and 500 mg;
• Granules for preparation of suspension for children, in bottles on 150 ml with the content of active agent in number of 60 g;
• Solution for injections, in ampoules on 5 and 10 ml with the maintenance of 100 or 200 mg of active agent.

Etazolum analogs on a way of action are the following medicines:

• Tablets Norsulfazolum, Sulfadimezinum, Urosulfanum;
• Linimentum, ointment and powder for topical and external use Streptocide;
• Solution for Sulfacylum-natrium injections.

Indications to use of Etazolum

Medicine Etazolum is appointed at treatment of infections which cause microorganisms, sensitive to effect of active agent (infections of skin, ENT organs, bile-excreting and respiratory tracts), namely:

• Bronchitis;
• Ugly faces;
• Pneumonia;
• Bacterial coloenteritis;
• Pyelitis;
• Gonorrhoeas;
• Dysentery;
• Cystitis.

Besides, Etazolum is effective for prevention of infectious complications after carrying out operations.

Contraindications

According to the instruction it is contraindicated to apply Etazolum at:

• Anemias;
• Renal failure;
• Azotemias;
• Inborn deficit glyukozo-6-fosfatdegidrogenazy;
• Liver failure;
• Porphyrias;
• To Nefrourolitiaza;
• Hypersensitivity to Etazolum components;

Pregnancy, as well as the lactation period, are a contraindication to use of Etazolum.

Etazolum route of administration

Etazolum in tablets according to the instruction is appointed:

• For adults – on 2 tablets (500 mg) to six times a day, but no more than 7 g of drug a day;
• The children's dosage depends on age and makes from 0,3 g (up to 2 years) to 0,5 g (6 years are more senior) on six times a day.

The course of treatment Etazolum according to the instruction varies from seven to ten days.

Etazolum in granules is intended for children of younger age who experience difficulties at drug intake in tablets. Before use of a granule dissolve in warm svezhekipyacheny water, bringing water volume to a tag of 100 ml. The received suspension within half an hour needs to be shaken up periodically.

The dosage of suspension depends on age of the child. The interval between receptions should not exceed four hours. A course of treatment – 7-10 days.

Solution for injections Etazolum is entered intramusculary or slowly intravenously by each eight hours. The maximum adult daily dose makes 6 g of Etazolum.

Medicinal interaction

At use of Etazolum in any dosage forms it is necessary to consider that drug:

• Strengthens effect of peroral and antiepileptic hypoglycemic medicines and anticoagulants;
• Increases risk of development of side effects from use of immunodepressants, tsitostatik, nefrotoksichny and gepatotoksichny medicines.

Manifestations of a gematotoksichnost of Etazolum strengthen miyelotoksichny drugs.

Side effects of Etazolum

According to responses Etazolum is transferred in most cases well. In rare instances use of Etazolum can lead to development:

• Hemolitic anemia;
• Headache;
• Medicinal hepatitis;
• Leukopenias;
• Dizzinesses;
• Intersticial nephrite;
• Thrombocytopenia;
• Dyspepsias (in the form of nausea, an abdominal pain, vomiting, diarrhea);
• Methemoglobinemias;
• Crystallurias;
• Agranulocytosis.

At reception of Etazolum treat the most probable allergic reactions:

• Toxic epidermal necrolysis (differently – a Lyell's disease);
• Skin rash;
• Acute anaphylaxis;
• Malignant exudative erythema.

Storage conditions

Etazolum belongs to a number of the drugs of the list B which are released from drugstores according to the recipe. A drug period of storage – from three to five years (depending on a dosage form).