Euphyllinum

Euphyllinum – broncholitic means.

Pharmacological properties

The Euphyllinum concerns to group of xanthines. It contains the main active ingredient - theophylline. Drug exerts the expanding impact on bronchial tubes, weakening their unstriated muscles and eliminating spasms. Besides, it improves work of cilia of an epithelium of respiratory tracts, improves reductions phrenic, intercostal and other respiratory muscles. The Euphyllinum stimulates a respiratory center in a myelencephalon, improves lung ventilation, blood saturation by oxygen and reduces the content of carbon dioxide in it, that is normalizes respiratory function.

The mechanism of action of the Euphyllinum consists in phosphodiesterase enzyme oppression thanks to what in fabrics tsAMF collects, receipt in cells of the calcium ions which are responsible for muscular contraction decreases and it relaxes muscles of bronchial tubes.

The Euphyllinum according to the instruction stimulates cordial activity, strengthening the frequency and force of reduction of a myocardium. It is capable to reduce a tone of blood vessels, preferential skin, kidneys and a brain. Exerting the weakening impact on venous walls in a small circle of blood circulation, drug reduces in it pressure.

Use of the Euphyllinum improves blood supply of kidneys thanks to what education and removal of urine increases.

Drug slows down aggregation of thrombocytes and does erythrocytes steadier against damage, that is improves rheological properties of blood.

It is known of tokolitichesky action of the Euphyllinum on a uterus, it also increases acidity of a gastric juice.

Means is well soaked up from a digestive tract, bioavailability reaches it 100%. At a concomitant use with food absorption is a little slowed down. It gets into breast milk and through a placenta. Metabolism of the Euphyllinum happens in a liver, its removal from an organism happens to urine.

Release form

The Euphyllinum according to the instruction is released in tablets on 150 mg, in ampoules in the form of 2,4% and 24% of solution.

Indications

Drug is used for removal of attacks of bronchial asthma, at the heart failure, stenocardia, a fluid lungs and other states connected with developments of stagnation. According to reviews the Euphyllinum effectively reduces pressure at hypertensive crises. It is applied in complex therapy of a stroke and other ischemic conditions of a brain, in treatment of an apnoea of newborns.

Contraindications

Use of the Euphyllinum is contraindicated at its intolerance, during the acute period of a myocardial infarction, at a collapse, a Bouveret's disease, premature ventricular contraction, epilepsy, a hyperthyroidism, a peptic ulcer, disturbances in work of a liver and kidneys, at prostate adenoma, diarrhea. Use of drug in tablets is not recommended 6 years are aged younger.

Application instruction of the Euphyllinum

In the form of solution the drug is administered intravenously and intramusculary, parenteral use is reasonable at treatment of the emergency and medical emergencies. In this case the dosage is calculated individually, depending on weight of a state on the patient's weight.

For adults in urgent situations the Euphyllinum dose according to the instruction is chosen at the rate of 6 mg/kg, it is parted in 20 ml of normal saline solution of sodium chloride, and entered intravenously slowly within at least 5 minutes.

The asthmatic status demands infusional purpose of drug in number of 720 – 750 mg. Parenterally do not recommend to enter the Euphyllinum longer than 14 days.

For simplification of a state at chronic obstructive diseases of lungs in an acute phase begin 5 – 6 mg/kg of drug with a dose. If necessary it is necessary to raise it very carefully, under control of contents it in blood.

In the tablets Euphyllinum accept 0,15 g from 1 to 3 times a day, after meal. The course of reception can last from several days to several months.

At an apnoea of newborns when apnoeas last of 15 seconds with a simultaneous urezheniye of serdtsebiyeniye, the initial dose of this means for newborns makes 5 mg/kg/days in 2 receptions. Administer the drug on the nazogastralny probe. At stabilization of a state pass to a maintenance dose 2 mg/kg/days into 2 receptions. Duration of use can make from several weeks to several months.

Depending on weight of a state and indications to the Euphyllinum at children the daily dose varies from 6 to 15 mg/kg.

For elderly patients it is necessary to be careful in treatment by drug. According to reviews the Euphyllinum strengthens side effects of glucocorticoids, mineralokortikoid and adrenostimulyator. Do not apply this means along with other derivatives of xanthines.

Side effects of the Euphyllinum

According to reviews the Euphyllinum is capable to cause such undesirable effects as sleeplessness, dizziness, excitement, headaches, a tremor, increase of serdtsebiyeniye, arrhythmias, heartaches, a lowering of arterial pressure, abdominal pains, nausea, heartburn, vomiting, diarrhea, allergic reactions, sweating strengthening, decrease in content of glucose in blood, changes in analyses of urine.