Kandibene

Kandibene – drug with fungicidal, antifungal and antibacterial action.

Form of release and structure

Kandibene is let out in the following dosage forms:

• Cream for external use of 1%: homogeneous, white, without foreign smell (on 30 g in tubas, on 1 tuba in a box);
• Solution for external use of 1%: slightly brownish color, transparent, with a smell of isopropyl alcohol (on 40 ml in dark glass bottles, on 1 bottle in a box);
• Tablets for vaginal use: biconvex, white, oblong, on tablets on 100 mg – an engraving of "CL" (on 3 pieces in planimetric bezjyacheykovy packagings, on 1 or 2 packagings in a box complete with 1 or 2 applicators).

 Is a part of 100 mg of cream for external use:

• Active agent: Clotrimazolum – 1 mg;
• Auxiliary components: benzyl alcohol, sorbitan monostearate, polysorbate 60, spermaceti, cetyl stearyl alcohol, 2 octyllauryl alcohol, water.

For external use is a part of 1 ml of solution:

• Active agent: Clotrimazolum – 10 mg;
• Auxiliary components: benzyl alcohol, propylene glycol, 2 octyllauryl alcohol, polyethyleneglycol 400, sodium citrate, isopropyl alcohol, water.

Vaginal is a part of 1 tablet:

• Active agent: Clotrimazolum – 100 or 200 mg;
• Auxiliary components: colloid silicon dioxide, monohydrate of lactose, corn starch, magnesium stearate, adipic acid (powder), sodium bicarbonate, коповидон, polysorbate 80.

Indications to use

Solution and external use cream

• Multi-colored deprive;
• The fungal infections of mucous membranes and skin caused by dermatophytes, drozhzhepodobny and mold mushrooms;
• Erythrasma;
• Candidosis vulvovaginitis;
• Trichomoniasis;
• The mycoses complicated by a secondary pyoderma.

Vaginal tablets

• The genital infections caused by drozhzhepodobny mushrooms of the sort Trichomonas vaginalis and/or Candida (trichomoniasis, a candidosis vulvovaginitis);
• The genital superinfections caused by the microorganisms showing sensitivity to active agent (Clotrimazolum);
• Sanitation of patrimonial ways to the prenatal period.

Contraindications

• I trimester of pregnancy;
• Hypersensitivity to drug components.

Vaginal tablets in the period of periods are not recommended to be applied. The feeding women need to carry out Kandibene's therapy in this dosage form with care.

Route of administration and dosage

Solution and external use cream
Kandibene is applied locally.

Cream and solution should be applied 2-3 times a day on the affected areas of skin which are previously cleared (with use of soap with neutral value рН) and dried up. Cream needs to be rubbed carefully.

Duration of a course of therapy makes:

• Dermatomycoses: it is not less than 4 weeks;
• Chromophytosis: 1-3 weeks;
• Fungus diseases of skin: before elimination of symptoms, and also on an extent of 2 weeks after that.

Vaginal tablets
Kandibene is applied intravaginalno, the tablet is entered in a dorsal decubitus with slightly bent legs as it is possible more deeply, more preferably – in the evening.

The recommended dosing mode:

• On 100 mg: on 1 tablet for 6 days;
• On 200 mg: on 1 tablet for 3 days.

After consultation of the doctor carrying out a repeated course of treatment is possible.

For the purpose of sanitation of patrimonial ways usually appoint 1 tablet of Kandibene once.

Side effects

Solution and external use cream
During therapy local reactions can develop: reddening, contact allergic dermatitis and burning sensation.

Vaginal tablets
During Kandibene's use there can be such disturbances as allocations from a vagina, an itch, burning and hypostasis of a mucous membrane of a vagina, a headache, a gastralgia, intercurrent cystitis, the speeded-up urination, pain during sexual intercourse, burning sensation in a penis at the sexual partner.

Special instructions

Vaginal tablets
To prevent urogenital reinfection, it is recommended to carry out simultaneous therapy of sexual partners.

For more successful treatment at trichomoniasis along with Kandibene it is necessary to use other drugs with systemic action (for example, metronidazole orally).

At a candidosis vulvitis (a simultaneous infection of vulvar lips and sites adjoining to them) it is recommended to use along with vaginal tablets drug locally in the form of cream.

At development of signs of hypersensitivity or irritation therapy is stopped.

At a liver failure it is necessary to control a functional condition of a liver periodically.

If the effect of therapy is absent within 4 weeks, it is necessary to confirm the diagnosis.

Pregnant women of a tablet are recommended to enter without applicator.

Medicinal interaction

Clotrimazolum at intravaginalny use lowers activity of Amphotericinum In and other half-yen antibiotic drugs.

Activity of Clotrimazolum at simultaneous use with nystatin can decrease.

Terms and storage conditions

To store in the place, unavailable to children.

Period of validity:

External
• use cream – 4 years at a temperature up to 25 °C;
• Solution for external use – 5 years at storage in usual conditions;
• Tablets vaginal – 3 years at a temperature up to 25 °C.