Codeine + Paracetamol
Application instruction:
Codeine + Paracetamol – the combined means with anesthetic, febrifugal, antibechic and analgeziruyushchy action.
Form of release and structure
Dosage form – tablets (on 10 pieces in a blister strip packaging, in a cardboard pack 2 packagings).
Content of active ingredients is to 1 tablet:
- Codeine (in the form of phosphate) – 8 mg;
- Paracetamol – 500 mg.
Indications to use
Drug Codeine use + Paracetamol is shown at treatment of the following diseases:
- Flu and catarrhal diseases – as antibechic and febrifugal drug;
- Neuralgia, arthralgia, radicular syndrome, migraine, tooth and a headache, musculoskeletal system injuries – for removal of a pain syndrome of moderate and easy degree of manifestation.
Contraindications
- Pulmonary insufficiency;
- Disturbances of breath against the background of oppression of a respiratory center;
- Heavy liver failure;
- Deficit glyukozo-6-fosfatdegidrogenazy;
- Disturbance of a hemogenesis;
- The expressed renal failure;
- Period of pregnancy and breastfeeding;
- Age up to 12 years;
- Hypersensitivity to drug components.
Route of administration and dosage
Tablets are intended for intake.
The dose and the period of treatment are appointed by the doctor on the basis of clinical indications.
The recommended dosing: on 1-2 tablets 3-4 times a day (every 4 hour).
The maximum daily dose – 8 tablets.
Without consultation of the doctor as febrifugal medicine use can last no more than 3 days, as anesthetic – no more than 5.
Side effects
Use of drug can become the reason of the following side effects:
- From the alimentary system: pains in epigastric area, nausea, vomiting;
- Allergic reactions: itch, skin rash, Quincke's disease;
- Others: at reception of high doses for a long time – development of medicinal dependence; very seldom – thrombocytopenia, anemia, a methemoglobinemia, functional disturbances in a liver and/or kidneys.
Special instructions
Contraindicated combined use with the drugs expectorating and containing paracetamol.
It is impossible to exceed the recommended dosing.
During administration of drug patients should be careful at occupation potentially dangerous types of activity which performance demands concentration of attention and high speed of psychomotor reactions, including at control of vehicles and mechanisms.
Medicinal interaction
At simultaneous use with antiepileptic means, barbiturates, rifampicin and ethanol (inductors of a microsomal oxidation), the risk of development of a hepatotoxic increases.
Drug strengthens clinical action of antiagregant, increasing probability of development of side reactions.
The drug Codeine combination + Paracetamol with monoamine oxidase inhibitors causes accommodation disturbance, an ataxy, paresthesias, hypotonia.
The concomitant use of the means oppressing the central nervous system strengthens impact on a respiratory center and sedation of drug.
Against the background of use of oral contraceptives there is a reduction in the rate of metabolism of paracetamol for 20-30%.
Codeine increases effect of ethanol on psychomotor function.
Terms and storage conditions
To store in the unavailable to children, protected from light, dry place.
Period of validity – 3 years.
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