Mildronate

Mildronate – the synthetic drug improving power supply and metabolism of fabrics.

Pharmacological action

Active ingredient of Mildronate improves metabolism, promotes removal of the saved-up toxins from cells, exerts tonic impact and protects cells from damage.

As a result of use of Mildronate ability to maintain loadings and to be recovered quickly after them increases. Thanks to these properties drug is used for improvement of blood supply of a brain and treatment of various disturbances of activity of cardiovascular system, and also increase in working capacity.

At heart failure Mildronate according to the instruction increases contractility of a myocardium, reduces the frequency of attacks of stenocardia, increasing at the same time tolerance to physical to loadings.

At ischemic disturbances of cerebral circulation Mildronate is applied to improvement of blood circulation in the ischemia center that promotes blood redistribution.

Also according to reviews Mildronate is effective at disturbances of a nervous system at an abstinence syndrome and at eyeground pathology.

Release form

Mildronate is produced in a look:

• Colourless transparent solution, 1 ml of drug contains 100 mg of active ingredient – a meldoniya. In ampoules on 5 ml;
• The white gelatin capsules containing active ingredient in the form of crystal powder with a slight smell. On 250 or 500 mg of active ingredient in the capsule, on 10 pieces in the blister.

Indications to Mildronate use

Mildronate is shown to use in complex therapy:

• At coronary heart disease, including a myocardial infarction and stenocardia, and also at heart failure and a dishormonal cardiomyopathy;
• At strokes and cerebrovascular insufficiency.

Also Mildronate is applied at:

• Reduced working capacity;
• Retinopathies of various etiology, including diabetic and hypertensive;
• Hemophthalmia and retinal apoplexies of various etiology;
• Physical overstrain;
• To fibrinferment of the central vein of a retina and its branches;
• Abstinence syndrome at an alcoholism, in a complex with specific therapy.

What properties of an organism drug can increase? What diseases can prevent/cure? Meldony does not increase any properties of an organism, it helps organism cells during ischemia more effectively to fight against a lack of oxygen, and also to protect them from destructive effect of substances which are formed of dlinnotsepochny fatty acids during ischemia. Thanks to the unique mechanism of action, meldony as drug of the second line, that is as additional therapy to the main, is applied to treatment of cardiovascular diseases, applied to maintenance and reduces symptoms of a mental and physical overstrain.

Contraindications

According to the instruction Mildronate is contraindicated to use at children's age up to 18 years, at hypersensitivity to drug, and also with the increased intracranial pressure, including intracranial tumors and disturbances of venous outflow.

Reliable researches on use of Mildronate during pregnancy and a lactation were not conducted owing to what drug is not recommended to be used during these periods.

Mildronate is applied with care, it is especially long, at diseases of a liver or kidneys.

Application instruction of Mildronate

The dose and route of administration of Mildronate depend on a disease:

• At the cardialgia developing against the background of dishormonal dystrophy of a myocardium Mildronate accept twice a day for 12 days on 250 mg;
• At cardiovascular diseases Mildronate is shown as a part of complex therapy, to 2 times a day on 0,5-1 g. Treatment is carried usually out from a month to 6 weeks;
• At chronic disturbances of cerebral circulation accept to 1-2 tablet of Mildronate (500 mg) in days a course from 4 to 6 weeks. According to indications treatment can be undergone several times a year;
• In an acute phase at disturbance of cerebral circulation Mildronate according to the instruction is entered intravenously for 10 days on 500 mg once a day. After that it is possible to pass to reception of the tablets Mildronate, 0,5-1 g a day. The general course of therapy usually makes up to 6 weeks;
• At the raised intellectual or exercise stresses accept on 1 tablet of Mildronate on 250 mg, up to 4 times a day within two weeks. A repeated course can be completed not earlier than in 2 weeks.

Athletes are recommended to apply Mildronate before trainings, twice a day on 0,5-1 g. During the preparatory period drug – from two to three weeks, during competitions – 2 weeks.

At the disturbances caused by an alcoholism usually accept 4 times a day on 1 tablet of Mildronate (500 mg) within 10 days.

Mildronate is shown to use in the first half of day because of a possibility of development of exciting effect.

Side effects

According to reviews Mildronate – low-toxic drug also does not cause side effects hazardous to health. Extremely seldom can arise:

• Changes of arterial pressure;
• Tachycardia;
• Dispeptic symptoms;
• Psychomotor excitement.

Also Mildronate according to reviews can cause allergic reactions in the form of hypostasis, rash, reddening or a skin itch.

It is necessary to be careful at simultaneous use with some anti-anginal and hypotensive drugs, and also cardiac glycosides as Mildronate strengthens their action.

At simultaneous use with Mildronate of antihypertensives, nifedipine, nitroglycerine, peripheral vazodilatator and alpha adrenoblockers moderate tachycardia and arterial hypotension can develop.

Mildronate can be accepted with anticoagulants and antiagregant, and also diuretic and antiarrhytmic means.

It should be noted especially safety of use of the drug Mildronate, it is one of the important factors explaining its wide recognition among doctors and patients. Safety Mildronate is confirmed by periodically updated reports on safety and results of the published clinical trials.

After Latvia entered into the European Union, existence of system of the Pharmakonadzor, responsible for observation and assessment of use of medicines became the obligatory requirement of regulatory bodies. Since the beginning of monitoring (since March 21, 2006) JSC Grindeks received 478 spontaneous reports (messages) on products, the containing meldoniya. The potential significant risk for health in these cases was not stated. Any message on development of dependence and accustoming to drug after its use did not arrive. Data on by-effects or reactions from athletes did not arrive.

Storage conditions

Mildronate is released according to the recipe. A solution period of storage for injections and tablets – 4 years.