Silhouette

Silhouette – the peroral contraceptive drug having anti-androgenic effect.

Pharmacological action of Siluyet

The components which are a part of tablets of Siluyet stimulate ovulation inhibition, change of structure of an endometria and vermicular movement of uterine tubes, and also increase in viscosity of cervical slime.

Release form

According to the instruction, Siluyet is let out in the form of film coated round, biconvex white or almost white tablets with an engraving of "G53" on one of the parties on 2 mg in blisters from PVC. One tablet contains 30 mkg of ethinylestradiol, 2 mg of a diyenogest, 47,66 mg of lactose of monohydrate, 1,3 mg of polyacrylate of potassium, 10,46 mg of starch of corn, 0,65 mg of a gipromelloza of 2910 and 1,3 mg of magnesium of stearate.

3 mg opadry II 85F18422 white are a part of a film cover of tablets of Siluyet (1,2 mg of polyvinyl alcohol, 0,75 mg of titanium of dioxide, 0,606 mg of a macrogoal of 3350 and 0,444 mg of talc).

Siluyet's analogs

Analogs of tablets of Siluyet on active ingredient are drugs Jeanine, Zhenetten and Diyetsiklen. On the mechanism of action and belonging to one pharmacological group carry to Siluyet's analogs:

• Belara;
• Jes;
• Euro;
• Lindinet 30;
• Novinet;
• Regulon;
• Силест;
• Triziston;
• Femoden;
• Egestrenol;
• Yarina;
• Oralkon.

Indications to Siluyet's use

According to the instruction, Siluyet is accepted as peroral contraception and at treatment of an acne.

Siluyet route of administration

According to the instruction, Siluyet is accepted daily at the same time on one tablet for three weeks. The subsequent reception of tablets of Siluyet begins in a week after the end of the previous packaging. Usually for seven days of a gap between reception of tablets bleeding of "cancellation" begins. If similar drugs were not used earlier, then the first reception of tablets begins in the first day of periods.

At implementation of abortion in the first trimester of pregnancy Siluyet's reception is appointed immediately, and at abortion in the second trimester or after the delivery reception of tablets begins in 3-4 weeks.

At the admission of reception of Siluyet for less than 12 h protection does not decrease, but if more than 12 h, then contraceptive protection can be reduced.

Contraindications

According to the instruction, it is contraindicated to Siluyet to apply at:

• Arterial and venous thromboembolic diseases now or in the anamnesis;
• Porphyrias;
• Thromboses and thrombembolia now or in the anamnesis;
• To jaundice and inborn hyperbilirubinemia;
• Sickemia;
• Smoking 35 years are aged more senior;
• Pancreatitis with the expressed gipertriglitseridemiya now or in the anamnesis;
• The states preceding thrombosis;
• Bleedings from a vagina of not clear genesis;
• Angiopatiya, retinopathy, uncontrollable arterial hypertension and heavy dislipoproteinemiya;
• Deficit of lactase, lactose intolerance and glyukozo-galaktozny malabsorption;
• The inborn or acquired predisposition to arterial fibrinferments;
• Severe forms of diseases of a liver;
• Liver tumors;
• Hormonedependent malignant diseases of generative organs or mammary glands;
• Migraines with local neurologic symptomatology;
• Epilepsies;
• Pregnancies and in the period of a lactation;
• Hypersensitivity to drug components.

With Siluyet's care appoint when smoking aged 35 years, a diabetes mellitus, a hysteromyoma, multiple sclerosis, endometriosis, controlled arterial hypertension, a dislipoproteinemiya, phlebitis of superficial veins, chronic heart failure, a disease Krone, a renal failure, bronchial asthma, diseases of a liver, a tetany are younger.

Side effects of Siluyet

According to reviews, Siluyet can cause a stroke, venous and arterial thromboses, thromboembolisms of a pulmonary artery and a myocardial infarction. The risk of display of these diseases increases at obesity, coagulability disturbance, smoking, thrombophlebitis, a varicosity, existence of arterial hypertension and thrombosis.

Also, according to reviews, Siluyet causes side effects from various systems of an organism, namely:

• Anemia (blood and lymphatic system);
• Arterial hypertension, tachycardia, varicosity, hematomas, arterial hypotension, pain on the course of veins, thromboses, thrombophlebitis of superficial veins, inflows, thrombophlebitis of deep veins, a thromboembolism of a pulmonary artery, a myocardial infarction and disturbance of cerebral circulation (cardiovascular system);
• Migraine, hyperexcitability, dizziness, headache, disturbance of cerebral circulation (nervous system);
• Vision disorders, dryness of a mucous membrane, conjunctivitis and intolerance of contact lenses (organs of sight);
• Gipoakuziya, sonitus, hearing disorder and its sudden loss (acoustic organs);
• Sinusitis, bronchitis and bronchial asthma (respiratory system);
• Nausea, gastritis, dyspepsia, vomiting, diarrhea, abdominal pain, enteritis, cholecystitis and cholelithiasis (alimentary system);
• Infection of an urinary system (kidneys and urinary tract);
• Acne, skin allergic reactions, akneiformny dermatitis, hloazma, alopecia, dieback, mnogoformny erythema, vascular purpura, hypertrichosis, knotty erythema, virilism, hyperhidrosis, skin itch, seborrhea, dandruff, eczema, Quincke's disease, teleangiectasias and hyperpegmentation (skin and hypodermic fabrics);
• Decrease or increase in body weight, decrease or increase in appetite (metabolism and food);
• Allergic reactions (immune system);
• Bleedings, dispareuniya, pain and morbidity of mammary glands, cysts of ovaries, a vaginitis, a vulvovaginitis, increase in mammary glands, strengthening of allocations from a vagina, a hyperplasia, to an endometria, mastitis, a salpingitis, acyclic bloody allocations or painful menstrualnopodobny bleedings, a leiomyoma, emergence of a secret of mammary glands, an endometritis, a fibrous and cystous dysplasia of mammary glands, a cervicitis, scanty menstrualnopodobny bleedings, a lipoma of a mammary gland, a vulvovaginal itch, cancer and to an endometria (generative organs and mammary glands);
• Depression, sleep disorders, decrease in mood, anorexia, sleeplessness, aggression, changes libido and apathy (mentality);
• Dorsodynia, arthralgias, mialgiya and spasms in gastrocnemius muscles (musculoskeletal system).

Also, according to reviews, Siluyet causes liver tumors, venous thromboembolic disturbances, a vaginitis, arterial hypertension, fungal infections, herpetic damage of an oral cavity, feeling of exhaustion, arterial thromboembolic disturbances, vaginal candidiasis, grippopodobny symptoms, hypostases and a hloazma in some women.

At Siluyet's overdose can cause acute toxicity, vomiting, nausea and bloody allocations from a vagina.

Siluyet storage conditions

According to the instruction, Siluyet needs to store in the unavailable to children and protected from light hit, dry place at the room temperature up to 25 °C. The period of storage at observance of recommendations makes 2 years.