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Simvastol

The prices in Internet drugstores:

from 202 rub.

Simvastol – medicine for decrease in level of cholesterol and lipids in blood.

Pharmacological action

Active ingredient of Simvastol is симвастатин – the connection received by fermentation of mold fungi of Aspergillus terreus. This chemical blocks one of early stages of synthesis of cholesterol in an organism, namely suppresses the enzyme which is the catalyst of formation of a mevalonat. Promotes lowering of the level of triglycerides, lipoproteins of the low and very low density (LPNP and LPONP) and concentration of cholesterol in a blood plasma. It is characteristic that Simvastol does not lead to formation of potentially toxic sterol. Increases the level of lipoproteins of the high density (LPVP). Promotes optimization of a ratio of LPNP from LPVP and the general cholesterol with LPVP.

Симвастол в таблетках (20 мг)

According to reviews of Simvastola from specialists, drug begins to render noticeable therapeutic effect 2 weeks later after the beginning of reception, reaching a maximum in 4-6 weeks. Effect of this medicine is reversible: after the termination of administration of drug indicators of cholesterol and lipids are returned to former values.

Form of release and Simvastol's list

Simvastol is issued in the form of tablets of pink, yellow and brown color, color depends on amount of active ingredient as a part of tablets. Pink contain 10 mg of a simvastatin, yellow – 20 mg, brown – 40 mg respectively.

In addition to a simvastatin, excipients are a part of tablets Simvastol: ascorbic acid, monohydrate of citric acid, monohydrate of lactose, butylhydroxyanisole, magnesium stearate, microcrystallic cellulose, prezhelatinizirovanny starch, dyes.

Tablets are packed into blisters on 14 pieces, 1 packaging contains 1 or 2 blisters.

Simvastol's analogs

A number of drugs with the same active ingredient in structure - simvastatiny, but issued other producers and differing in auxiliary components belongs to Simvastol's analogs: Aktalipid, Avestatinaterostat, Vazilip, Vero-Simvastatin, Zovatin, Zorstat Ovenkor, Zokor, Zokor forte, SIMVAGEKSAL, Simvakol, Simvalimit, Simvakard, Simvastatin-Fereyn Simvastatin, Simvor, Simgal, Simlo, Simvastatin Alkaloid, Simplakor, Holvasim, Sinkard, Simvastatin Pfayzer.

Indications to use

According to the instruction Simvastol is shown to use at the following pathologies:

  • Primary hypercholesterolemia like IIA and IIb at the patients having risk of developing of coronary atherosclerosis at inefficiency of non-drug treatment, namely the diet directed to decrease in body weight in combination with the strengthened exercise stress;
  • Hypercholesterolemia in combination with a gipertriglitseridemiya, also at inefficiency of non-drug therapy;
  • At the diagnosed coronary heart disease (CHD) for the purpose of delay of progressing of coronary atherosclerosis, prevention of acute disorders of function of cardiovascular system: stroke, myocardial infarction, tranzitorny (passing) attacks of ischemia of heart and brain;
  • By preparation for holding a procedure of revascularization for the purpose of decrease in risk of emergence of postoperative complications.

Application instruction of Simvastol

Reviews of Simvastola from cardiologists specify that drug works more effectively at observance of the diet directed to decrease in the general cholesterol in blood. Such diet needs to be supported throughout all course of treatment by this medicine. According to the instruction Simvastol accept orally, once a day, in the evening, washing down a tablet with enough water.

The dosage of drug is selected according to individual indications, the average dose fluctuates from 5 to 20 mg a day. Treatment by Simvastol is begun with small doses, at insufficient efficiency of the clinical answer within 4 weeks the dose is increased by 10 mg a day, it is possible to raise a dosage each 4 weeks, under control of laboratory indicators of blood. The maximum daily dose of Simvastol usually makes 40 mg, at some states increase to 80 mg is admissible.

Side effects

At therapy by Simvastol and analogs the following undesirable effects were noted:

  • From digestive organs – dyspepsia symptoms, hepatitis, pancreatitis;
  • From a nervous system – a headache, dizziness, sleep disorders, an adynamy, paresthesias, a convulsive syndrome, flavoring perversions, vision disorders, a peripheral neuropathy;
  • From cardiovascular system – tachycardia, short wind;
  • From laboratory indicators - a superactivity of an alkaline phosphatase, a kreatinfosfatkinaza, hepatic transaminases, increase SOE, thrombocytopenia, an eosinophilia;
  • From a musculoskeletal system – muscular and joint pains, a myasthenia, a myopathy, рабдомиолиз, arthritis;
  • From immune system – Simvastol's use can cause numerous allergic and autoimmune processes: urticaria, fever, photosensitization, Quincke's disease, vasculitis, rheumatic polimialgiya, volchanochnopodobny syndrome;
  • From integuments – a skin itch, rash, a dermatomyositis, an alopecia;

Others: rushes of blood to the person, anemia, decrease in a libido and potentiality, renal failure.

Contraindications to Simvastol's use

According to the instruction Simvastol is contraindicated at the following states:

Симвастол в таблетках (10 мг)

  • Individual hypersensitivity to a simvastatin and other drugs of a number of statines;
  • Abnormal liver functions;
  • Myopathies;
  • Porphyria;
  • Pregnancy and breastfeeding.

Researches concerning safety of use of Simvastol for persons more young than 18-year age therefore reception by its this category of patients is undesirable were not conducted.

At parallel use of other medicines Simvastol and analogs it is necessary to appoint with extra care as his combination to some of drugs causes strengthening of toxic action on an organism, in other cases there is a disturbance of assimilation of drugs and their metabolism.

Rules of storage and issue

Tablets Simvastol store in the dry place, out of access of direct light, at the air temperature which is not exceeding 20 °C. Period of validity 3 years.

To protect from children.

Simvastol is released according to the recipe of the doctor, is not intended for independent use.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Simvastol Richter

202 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Simvastol тбл п / about 10 mg No. 28, Gedeon Richter

206 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Simvastol тбл п / about 20 mg No. 28, Gedeon Richter

314 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC
 
 
Whether you know that:

Blood of the person "runs" on vessels under huge pressure and at disturbance of their integrity is capable to shoot of distance to 10 meters.