Stamlo

Stamlo – anti-anginal and an antihypertensive from group of blockers of calcium channels of the third generation.

Pharmacological action of Stamlo

The main active ingredient of drug – амлодипин. At the membrane level амлодипин contacts dihydropyridinic receptors, blocking thus calcium channels. Calcium ions are necessary for muscle cells for reduction. Stamlo reduces transport of calcium ions in cells (generally in smooth muscle and cells of cardiac muscles), reducing thus their sokratitelny ability. Drug affects unstriated muscles of vessels, expands coronary arteries (they feed a cardiac muscle) and peripheral arterial vessels with the size up to arterioles (as in their wall still there are smooth muscle fibers). So Stamlo lowers the general peripheric resistance of vascular network, reduces preload of heart and reduces the need of a myocardium for oxygen.

During a stenocardia attack the coronary vessels feeding heart are narrowed, intake of oxygen in a myocardium decreases, metabolism products quickly collect, as causes characteristic pain in heart. Stamlo expands coronary arteries and together with an arterial blood increases receipt to oxygen heart.

Also Stamlo interferes with tightening of coronary arteries (that happens for example, when smoking). Against the background of drug intake the people sick with stenocardia begin to transfer better an exercise stress, progressing of stenocardia is slowed down and its attacks disturb patients less that allows to use less often nitroglycerine for its stopping.

Against the background of long reception of Stamlo the hypertrophy of a myocardium of a left ventricle created already can decrease. In general it exerts cardiotyre-tread (protective) impact at coronary heart disease.

The effect of Stamlo's reception gradual, can pass several hours prior to action, that is it is not drug of first aid, but there lasts once accepted dose for days.

Pressure decrease of Stamlo provides due to influence on smooth muscles of peripheral arteries, hypotensive effect depends on a dose. The single dose of drug can reduce pressure for the whole days, and it does not increase again depending on a pose which is accepted by the person – standing or sitting. Pressure decreases unsharply therefore patients feel well during treatment and quietly transfer a usual exercise stress. Still Stamlo has a weak natriuretic effect – increases sodium removal by kidneys that too is capable to reduce arterial pressure a little.

Stamlo according to the instruction difficult interacts with other medicines at a concomitant use therefore treatment is not recommended to them without participation of the doctor.

Form of release of Stamlo

Stamlo is let out in tablets on 5 mg and 10 mg.

Indications to use

According to Stamlo's instruction it is shown at coronary heart disease (vasospastic and an angina of exertion) and bezbolevy ischemia of a myocardium, with the increased arterial pressure, as auxiliary treatment at a decompensation of chronic heart failure.

Contraindications to Stamlo's use

It is impossible to apply Stamlo at heavy arterial hypertension, during pregnancy and a lactation, at intolerance of components of drug. Carefully under constant medical and tool control at coronary heart disease against the background of the lowered pressure, at an acute myocardial infarction and within 1 month after it, at a chronic heart and liver failure, at elderly, at a mitral stenosis, a hypertrophic cardiomyopathy and a sick sinus syndrome.

Efficiency and safety of use of Stamlo at children are younger than 18 years are unknown.

Application instruction of Stamlo

According to Stamlo's instruction accept inside once a day. Begin 5 mg/days with a dose, za1-2 weeks bring it to 10 mg/days, such dose effectively prevents emergence of attacks of stenocardia. At vasospastic and anginas of exertion once accept 5-10 mg. At arterial hypertension the recommended dose of 2,5 - 5 mg/days. In complex therapy of chronic heart failure an initial dose of 2,5 mg once a day if the patient well transfers it, then gradually the dose is raised to 10 mg/days. The course can be long, it is defined by the attending physician. In case of end of a course gradual reduction of a dose is recommended.

Side effects

Stamlo can render a number of undesirable effects on different systems of an organism, it can be, for example, headaches, drowsiness, spasms, changes of mood, nausea, an abdominal pain, heartbeat and hypostases, "inflows" of blood to the person, dermatitis, a xeroderma, allergic reactions. At emergence of similar symptoms it is necessary to cancel drug and to see the attending physician.