Tioctacidum

Tioctacidum – the medicine with antioxidant action regulating lipidic and carbohydrate metabolism in an organism.

Pharmacological action

Active component of Tioctacidum – thioctic acid, being endogenous antioxidant, it is close to group B vitamins (on the biochemical mechanism of influence) and is necessary in an organism for:

• Protection of cells against toxic action of the resulting processes of a metabolism of free radicals;
• Improvements of a trophicity of neurons;
• Neutralizations of exogenous toxic connections that promotes decrease in expressiveness of symptoms of a polyneuropathy;
• Increases in utilization of glucose.

Thus, Tioctacidum according to the instruction renders hypolipidemic, hepatoprotective, hypoglycemic and gipokholesterinemichesky action.

Release form

The drug Tioctacidum is produced in a look:

• The yellowish transparent solution for injections (Tioctacidum of 600 T) containing 600 mg of thioctic acid in each ampoule. On 5 ampoules in planimetric packaging;
• Oblong, film coated tablets of flavovirent color (BV Tioctacidum) containing 600 mg of active agent.

Tioctacidum analogs

Drugs belong to the main analogs of Tioctacidum on active ingredient: Berlition 300, Oktolipen, Lipotiokson, Thioscale, Lipamidum, Tiolepta, Tiolipon, Lipoic acid, Espa-Lipon and Neyrolipon.

In certain cases on medical appointment it is possible to apply Tioctacidum analogs on a way of action: Bifiform Kids, Gastrikumel, Zavesk and Orfadin.

Indications to use of Tioctacidum

According to the instruction Tioctacidum is appointed for treatment of a diabetic and alcoholic polyneuropathy.

Contraindications

It is contraindicated to apply Tioctacidum according to the instruction (due to the lack of sufficient clinical data) in the following cases:

• At pregnancy;
• At a lactation;
• In pediatrics (up to 18 years).

Besides, Tioctacidum is not appointed at the existing hypersensitivity to thioctic acid or auxiliary components of medicine.

Tioctacidum route of administration

The pill Tioctacidum is taken for half an hour till a breakfast once a day. The daily dosage according to the instruction makes one tablet.

At a severe disease treatment is usually begun with intravenous administration of Tioctacidum (on an extent from two to four weeks) then use of medicine in the form of tablets is possible.

Side effects of Tioctacidum

Most often at use of Tioctacidum disturbances in a look according to reviews develop:

• Nausea;
• Dizzinesses.

It is possible to refer the following states to very rare side effects arising at reception of Tioctacidum according to reviews:

• Diarrhea, vomiting, pain in a stomach and intestines, change of flavoring feelings (alimentary system);
• Skin rash, itch, small tortoiseshell, acute anaphylaxis (allergic reactions).

In certain cases (owing to glucose utilization improvement) at use of Tioctacidum according to reviews there can be hypoglycemia symptoms:

• The increased sweating;
• Confusion of consciousness;
• Visual disturbances;
• Headache.

At use of Tioctacidum in the form of solution for injections in rare instances there are frustration of a nervous system in a look:

• Spasms;
• Diplopias;
• Sharp increase in intracranial pressure and breath holding (at bystry intravenous administration) which, as a rule, take place independently.

At reception of Tioctacidum in high doses (more than ten tablets in one step) there can be disturbances testimonial of serious symptoms of intoxication, namely:

• The expressed disturbances of acid-base equilibrium that can lead to a laktatsidoz;
• Generalized convulsive attacks;
• Disturbances of coagulability of blood (sometimes leading to a lethal outcome);
• Hypoglycemic coma.

In cases if there is a suspicion on overdose by Tioctacidum, it is necessary to carry out immediate hospitalization with the subsequent performing symptomatic and anticonvulsant therapy, and also necessary measures for maintenance of functions of the affected vitals.

Medicinal interaction

At use of Tioctacidum according to the instruction it is necessary to avoid the following joint combinations:

• With Cisplatinum (because of decrease in its efficiency);
• With the medicines containing some metals (for example, drugs of magnesium, iron and calcium). In case of need simultaneous use of Tioctacidum with these drugs it is recommended to sustain an interval between receptions at five-six o'clock;
• With insulin or peroral hypoglycemic drugs (because of strengthening of action of the last);
• With ethanol and its metabolites (because of decrease in therapeutic effect of reception of Tioctacidum and increase in risk of development of a polyneuropathy).

Tioctacidum storage conditions

Tioctacidum belongs to a number of medicines which issue from drugstores is possible only according to the medical recipe (list B). A drug period of storage – 4 years (at a temperature up to 30 °C, in the place protected from light).