Trental

Trental is the medicine relating to group of the drugs improving microcirculation of vasoprotectives. Active ingredient – пентоксифиллин is a part of drug. Drug has ability to improve rheological properties of blood, to normalize elasticity of erythrocytes, to reduce aggregation of thrombocytes, to reduce viscosity of blood. Reducing plasma concentration of plasminogen, Trental improves processes of a fibrinolysis. At use of Trental cyclic adenosinemonophosphate in smooth muscle cells of a vascular wall, and also in blood collects. Trental is capable to block enzyme phosphodiesterase, to render some myotropic vasodilating effect. This drug reduces OPSS and increases minute systolic volume that should be considered at purpose of Trental. Indications to use of this drug are quite extensive thanks to considerable improvement of microcirculation and processes of cellular respiration, improvement of exchange processes in TsNS.

At oral administration Trental is well absorbed in a GIT. The maximum plasma concentration is reached in an hour after reception. It is metabolized generally in a liver. In an organism Trental is metabolized almost completely, removed by kidneys. An elimination half-life – 1,5 – 2 hours. At pathology of a liver and kidneys the elimination half-life of drug increases that needs to be considered at purpose of Trental.

Indications to Trental use

In the instruction to Trental such indications to its use are specified:

• encephalopathy of atherosclerotic genesis, distsirkulyatorny encephalopathy, ischemic stroke;
• pathology of peripheric circulation of a different etiology, including diabetic, atherosclerotic and caused by inflammatory processes;
• Raynaud's disease, other angioneyropatiya;
• circulatory unefficiency in retina vessels;
• the circulatory unefficiency in an inner ear which is followed by a hearing loss;
• pathology of a respiratory organs with the obstruction phenomena (including HZL and bronchial asthma);
• trophic ulcers, freezing injuries, gangrene;
• the pathology of sexual function caused by a circulatory unefficiency.

Contraindications to Trental use

According to the instruction, Trental is contraindicated at:

• individual intolerance of components of drug;
• tendencies to bleedings;
• hemorrhagic stroke;
• retinal apoplexies;
• pregnancies and lactations.

Route of administration, Trental dosage

Solution for injections

According to the instruction, Trental in the form of solution is intravenously kapelno applied to injections or struyno. For preparation of infusion solution as solvent use Ringer's solution, normal saline solution of sodium of chloride or glucose. The dosage in some cases fluctuates from 100 to 600 mg one or two times a day. The drug should be administered slowly: 100 mg within not less than 60 minutes. At heavy disturbance of processes of blood circulation purpose of infusion for 24 hours is possible. In such situation the dosage of Trental is calculated proceeding from the mass of the patient: 0,6 mg/kg, no more than 1200 mg a day. The volume of infusion solution should not exceed 1500 ml a day.

Trental dosage for jet use makes 100 mg. Time of jet infusion – not less than 5 minutes. Frequency rate of introduction – 1-2 times a day. At jet infusion the patient shall be in horizontal position.

If necessary perhaps parallel use of Trental in the tableted form.

Tablets

The dosage of drug and duration of a course of treatment is selected the doctor in an individual order. The average daily dosage makes 6-8 tablets of Trental. Indications to purpose of the tableted form – prolongation of therapy or the combined treatment. The maximum daily dosage should not exceed 1200 mg.

Side effects of Trental

Trental and analogs are usually quite well transferred. Numerous reviews of Trental from the patients applying it also testify to it. When using this drug the following side effects were noted:

• from bodies of a GIT: vomiting, nausea, stomach ache, disturbance of a chair;
• from bodies of CCC and hemopoiesis: hyperemia of the person, upper body, disturbance of a cordial rhythm, stenocardia attacks, decrease in the ABP, hypofibrinogenemia, thrombocytopenia;
• from TsNS: dizziness, headache, concern, disturbance of sleep patterns and wakefulness, irritability; at overestimate of the dosage specified in the instruction to Trental developing of aseptic meningitis was noted;
• allergic reactions: urticaria, itch, Quincke's disease, allergic rhinitis, acute anaphylaxis.

Special instructions

It is necessary to appoint carefully Trental and analogs patients with heavy atherosclerosis of coronary, cerebral vessels, with the unstable ABP, a GIT canker, heart failure, to postoperative patients.

Overdose

At overdose of Trental emergence of nausea, vomiting, gastric bleeding, tachycardia, dizziness, hypotension was noted. When using repeatedly exceeding the specified maximum of doses fervescence, excitement, spasms, a loss of consciousness, an areflexia was noted. The specific antidote does not exist. Carrying out a gastric lavage, symptomatic therapy, reception of enterosorbents is recommended. At heavy intoxication constant control of vital functions is necessary.

Responses

Trental causes considerable improvement of microcirculation. Reviews of Trental from doctors speak about high performance of drug at heavy pathology of TsNS, bodies of cardiovascular system, peripheric circulation. Reviews of Trental from patients also speak about efficiency and easy portability of this medicine at observance of the mode of the specified dosage.

Trental analogs

Now in drugstores it is possible to meet the following analogs of Trental: Agapurin, Arbifleks, Vazonit, Pentamon, Pentilin, Pentogeksal, Pentoksifillin, Pentomer, Rabomin, Ralofekt, Trenpental, Fleksital.

Interaction of Trental with other drugs

Trental strengthens effect of heparin and fibrinolitic drugs. Mutual potentiation at simultaneous use of Trental and APF inhibitors, insulin, peroral antidiabetic means is observed.

Storage conditions

Trental should be stored at the room temperature.

Before use of drug it is necessary to study carefully the instruction to Trental. Drug is appointed only by the doctor.