Paraproteinemic hemoblastosis

Description:

Payoraproyoteyoiyonemiyocheyosky gemoyobyolayostoyoza are an osoyoby group of an opuyokhoyoly limfayotiyocheyosky siyosyotema, at koyotoyory opuyokhoyoleyovy kletyok (limfotsiyota or plazmayotiyocheyosky) sinyoteyoziyorut имму­ног­ло­бу­лин.

Symptoms of the Paraproteinemic hemoblastosis:

The Kliyoniyocheyosky karyotiyona in the nayochayol of a boyolezyona does not imeyot tipichyony lines. On a meyora a progresyosiyoroyovayoniya of a protsesyos vozyoniyokat pain in poyozvonyoka, koyoreshyokoyovy sinyodry, pain in reyobyora, obuyosyoloyovyolenyony razyoruyosheyoniyoy (gnezdyony or diffuzyony) koyosyoty rasyotushchy plazmotsiyotomy. Inogyoda of a veyodushchiyoma ста­но­вят­ся priyozyonayok, svyayozanyony with ugyoneyoteyoniyoy proyoduktion of a kostyony mozyog: anemia, a grayonuyolotsiyotopeyoniya with its infektsiyoonyony osyolozhyoneyoniyoyam, tromyobotsiyotopeyoniyocheyoskiya of gemoryoragiyocheyoskiya sinyodry. In other sluyochayoyakh a veyodushchy simpyotom doyovolyyono быст­ро ста­но­вит­ся a nayorasyotayushchy proyoteyoiyonuyoriya, a poyochechyony neyodoyostayotochyonost.

Reasons of the Paraproteinemic hemoblastosis:

To Poyoskolk these leyyokoyoza, as well as others, vozyoniyokat from odyony peryovonayochalyyono an izmeyonenyony kletyoka, all masyosa opuyokhoyoleyovy a kleyotok proyoizyovoyodit ка­кой one имму­ног­ло­бу­лин, koyotoyory, even оста­ва­ясь normalyyony, ока­зы­ва­ет­ся for an orgayonizm in tseyoly besyopoyolezyony or vredyony because of a svoyoy krayyony izyobytochyonoyosta. As пра­ви­ло, син­тез ostalyyony immuyonogyoloyobuyoliyon it is reduced; poyosyotepenyono the immuyonoyologiyocheyosky neyosoyostoyoyayotelyyonost of an orgayonizm nayorasyotayot. To payoraproyoteyoiyonemiyocheyosky gemoyobyolayostoyoza от­но­сят­ся miyoeyolomyony бо­лезнь, Valyyodenyostrem's mayokyorogyoloyobuyoliyonemiya, бо­лезнь tyazheyoly chains. These leyyokoyoza a svoyoy kleyotochyony subyostrayot have preyoimushcheyostvenyono zreyoly elemenyota — plazmotsiyota, limfotsiyota therefore dolzhyona от­но­сить­ся to group of hroyoniyocheyosky leyyokoyoz. Besides, спо­соб­но­стью to a sinyoteyoz од­но­тип­но­го, moyonoyokyoloyonoyovy (i.e. proyoizyovoyodimy kletyokam, proyoisyokhoyodyashchiyom from odyony peryovonayochalyyono an izmeyonenyony kletyoka) the immuyonogyoloyobuyoliyon is obyolayodat by sleyoduyushchy opuyokhoyol of a kroyoveyotvoryony siyosyotema: ostyory plazmoyobyolastyony лей­коз, redyoky forms limfosyoaryoky and redyoky forms zreyoloyokleyotochyony limfayotiyocheyosky vneyokostyonomozgoyovy opuyokhoyoly - limfotsiyoty.

Treatment of the Paraproteinemic hemoblastosis:

With a big tumoral weight practically there are always direct indications to cytostatic therapy (pains, pathological fractures, anemia, a syndrome of the increased viscosity, bleeding, a renal failure, a hypercalcemia). At somatic and hematologic the compensated patients (a stage 1A and HA), when there is no absolute indications to use of cytostatic means, waiting tactics with control of indicators of blood monthly is recommended. At a part of such patients it is possible to reveal a slow form of a disease without progressing signs within several years. It is clear, that at symptoms of increase of tumoral weight it is impossible to postpone treatment.