Pheochromocytoma
Contents:
- Description
- Pheochromocytoma reasons
- Pheochromocytoma symptoms
- Treatment of the Pheochromocytoma
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Description:
The first message on a pheochromocytoma was made in 1904 by Marchetti according to autopsy, and the first oncotomy with a presurgical dianoz was made in 1942 by Evans.
Feokhromotstoma is a hormonal and active tumor.
Pheochromocytoma reasons:
The pheochromocytoma comes from chromaffin cells of a medulla of adrenal glands, is more rare from accumulation of these cells in gangliya of a sympathetic nervous system.
Studying of family cases of a tumor allowed to establish an autosomal and dominant mode of inheritance with high penetrance and a big variety of symptomatology and localization of a tumor. Multiple tumors happen at children more often than at adults. They can be observed in gangliya of retroperitoneal space, paragangliya of a sympathetic nervous system in adrenal glands, vessels of kidneys. Are shown in all age periods of the childhood including at babies. Meet more often than are diagnosed.
Pheochromocytoma symptoms:
- arterial hypertension is the main symptom of a disease; at children to a bowl, than at adults, AG has constant character though, as well as adults, can have hypertensive crises;
- the headache, perspiration are noted.
Other symptoms have different degree of manifestation and presence at a clinical picture:
• nausea;
• vomiting;
• abdominal pain;
• at a third of patients the vplotdoslepoga vision disorder owing to a gipertenzionny retinopathy is noted;
• intracerebral bleedings with focal neurologic symptomatology are possible.
The listed symptoms are not specific to a pheochromocytoma. At the slightest suspicion it is necessary to resort to the main laboratory diagnostic methods: to definition of catecholamines and their metabolites. Define in urine of a metanefrina and that it is especially diagnostically important — vanililmindalny acid (BMK) which is a product of their oxidizing deamination. The diagnosis is confirmed if concentration of VMK by 10 times exceeds norm (2 — 7 mg). When krizovy disease takes place, the level of catecholamines and VMK should be determined to crisis and in the first 3 h after it. Then establish localization of a tumor by means of visual methods of a research.
Treatment of the Pheochromocytoma:
Perhaps early surgical oncotomy. After operation the condition of the patient quickly improves, all functional deviations are normalized.