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medicalmeds.eu Medicines Antihistaminic drugs for system use. Klarisan

Klarisan

Препарат Кларисан. АО "Химфарм" Республика Казахстан


Producer: JSC Himfarm Republic of Kazakhstan

Code of automatic telephone exchange: R06AX13

Release form: Firm dosage forms. Tablets.

Indications to use: Allergic rhinitis (cold). Sneezing. Small tortoiseshell. Quincke's disease of Quincke.


General characteristics. Structure:

Active agent - лоратадин 10,0 mg.

Excipients: lactose of 47,6 mg, microcrystallic cellulose of 23,7 mg, starch of 18,0 mg, magnesium or calcium stearate of 0,7 mg.




Pharmacological properties:

Pharmacokinetics. It is soaked up quickly and it is almost completely metabolized in an organism. The maximum concentration makes 1,3-2,5 hours, an elimination half-life – 8 hours. About 80% are removed in the form of metabolites with urine and a stake in equal ratios within 10 days, about 27% - with urine within the first days.

Pharmacodynamics. Blocker histamine H1 receptors. Drug has antiallergic, antipruritic, anti-exudative effect. Prevents development and facilitates the course of allergic reactions. Reduces permeability of capillaries, edematization of fabrics warns, reduces the increased sokratitelny activity of smooth muscles caused by action of a histamine.


Indications to use:

- prevention and treatment of seasonal and year-round allergic rhinitis and elimination of the symptoms connected with these diseases: sneezing, itch of a mucous membrane of a nose, rhinorrhea, burning sensation and itch of eyes, small tortoiseshell, Quincke's edema

- other skin diseases of an allergic origin.


Route of administration and doses:

Inside, to food. To adults and children 12 years are more senior (or at body weight more than 30 kg) appoint 10 mg (1 tablet) of 1 times a day; to children aged from 2 up to 12 years (at body weight less than 30 kg) – on 5 mg (1/2 tablets) of 1 times a day. The effect is shown in half an hour after reception and remains for 24 hours. In case of the admission of the next administration of drug it is not necessary to accept a double dose. The tablet is recommended to be swallowed entirely, without chewing, having washed down with enough water. Duration of treatment is defined individually by the doctor.


Features of use:

Patients with insufficiency have functions of a liver or with a renal failure the dose is selected individually.

Use during pregnancy only on doctor's orders according to strict indications. Loratadin gets into breast milk therefore drug is not appointed in the period of a lactation. In need of treatment it is necessary to stop breastfeeding.

Considering emergence of side effects it is necessary to be careful at use of drug at management of transport or work with other mechanisms.


Side effects:

- increase in appetite, nausea, vomiting, dryness in a mouth

- a headache, fatigue, drowsiness, excitability at children 

- unpleasant feelings in a stomach, dysfunctions of intestines 

- allergic reactions in the form of rash

Very seldom - an anaphylaxis, an alopecia, an abnormal liver function, tachycardia.


Interaction with other medicines:

At combined use with erythromycin, ketokonazoly and Cimetidinum concentration of a loratadin and its active metabolite in a blood plasma increases, but it is not followed by clinical manifestations. Klarisan does not exponentiate effect of alcohol on the central nervous system.


Contraindications:

- intolerance or hypersensitivity to a loratadin or any other component of drug

- children's age up to 2 years

- pregnancy


Overdose:

Symptoms: headache, drowsiness, tachycardia.

Treatment: it is necessary to wash out immediately a stomach and to accept absorbent carbon. If necessary: symptomatic and maintenance therapy.


Storage conditions:

To store in the dry, protected from light place, at  a temperature from 2 °C to 30 °C.

To store in the place, unavailable to children!


Issue conditions:

According to the recipe


Packaging:

Tablets on 10 mg in a blister strip packaging No. 10, in a cardboard pack 1 blister.



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