Polinadim

General characteristics. Structure:

Active ingredient: 1 ml дифенгидрамин  1 mg; naphazoline of 250 mkg;

Excipients: boric acid (15 mg/ml), methyl cellulose water-soluble (1.5 mg/ml), pyroborate sodium decahydrate (500 mkg/ml), dinatrium эдетат (600 mkg/ml), water for and (to 1 ml).

Description: drops eye in the form of transparent, slabookrashenny liquid.

Pharmacological properties:

The combined drug for topical administration in ophthalmology.

Difengidramin - a blocker histamine H1 receptors, has antiallergic effect. Reduces hypostasis, an itch, dacryagogue.

Naphazoline - alpha адреномиметик, causes long narrowing of peripheral vessels. Thanks to vasoconstrictive action at topical administration has antiedematous effect.

 

Pharmacokinetics. Data on pharmacokinetics of the drug Polinadim® are not provided.

Indications to use:

— acute allergic conjunctivitis (including polynosic conjunctivitis);

— conjunctivitis at a medicinal allergy;

— infectious diseases of eyes with an acute allergic component (as an additional tool).

Route of administration and doses:

The adult at acute symptoms drug is appointed on 1 drop in a conjunctival sac by each 3 h before reduction of hypostasis and irritation of eyes, then - on 1 drop 2-3 before disappearance of clinical symptoms.

To children 2 years are more senior appoint 1-2 drops /

Treatment duration - no more than 5 days. The doctor solves need of more prolonged use of drug individually.

At preservation of symptoms of irritation of a conjunctiva more than 72 h it is necessary to stop drug use.

Features of use:

It is not necessary to use drug more often than in each 3 h (within 5 days).

Drug is not intended for intake or introduction in the form of injections.

In case of the symptoms testimonial of system absorption, it is necessary to stop drug use.

At symptoms of an allergy and during treatment drug does not recommend to use soft contact lenses. If their use is necessary, then lenses should be removed before instillation and to establish back not earlier than in 15 min.

Influence on ability to driving of motor transport and to control of mechanisms

As after instillation sight clearness is temporarily broken, right after drug use patients should abstain from driving of motor transport and the activity demanding sight clearness.

Side effects:

Local reactions: symptoms of irritation of a conjunctiva (burning in eyes, a conjunctiva hyperemia, an itch), and also a vision disorder, increase in intraocular pressure, a mydriasis, eye pain, a xeromycteria. These reactions disappear after drug withdrawal. The isolated case of opacification of a cornea (is described at use within 7 days not less than 10 times/) which disappeared after the treatment termination by drug.

System reactions: seldom (especially at children and patients of advanced age) - pallor of integuments, tachycardia, pains in heart, increase in the ABP, sweating strengthening, a shiver, a headache, excitement, nausea, drowsiness, dizziness.

Interaction with other medicines:

At simultaneous use with tricyclic antidepressants strengthening of vasoconstrictive effect of naphazoline is possible.

Use of MAO inhibitors along with naphazoline or within 10 days after their cancellation can lead to hypertensive crisis.

Contraindications:

— conjunctiva xerosis (dry keratoconjunctivitis, Shegren's syndrome);

— simultaneous use with MAO inhibitors and the period within 10 days after their cancellation;

— closed-angle glaucoma;

— pregnancy;

— lactation period;

— children's age up to 2 years;

— hypersensitivity to drug components.

With care it is necessary to use drug at a thyrotoxicosis, arterial hypertension, atherosclerosis, arrhythmia, chronic rhinitis, bronchial asthma, adenoma of adrenal glands, at patients of advanced age, at a benign hyperplasia of a prostate with existence of a residual urine.

 

Use of the drug POLINADIM® at pregnancy and feeding by a breast
Use of drug at pregnancy and in the period of a lactation (breastfeeding) is possible only in that case when the estimated advantage for mother exceeds possible risk for a fruit or the child.

 

Use for children
Contraindication: children's age up to 2 years.

Overdose:

At topical administration of drug the overdose is improbable.

Symptoms: at children under 6 years at prolonged and frequent use oppression TsNS, a hypothermia, a long mydriasis, increase in the ABP, tachycardia is possible.

Treatment: performing symptomatic therapy.

Storage conditions:

Drug should be stored in the unavailable to children, protected from light place at a temperature from 15 °C to 25 °C; not to freeze. A period of validity - 2 years.

After opening of a bottle a drug period of storage - 1 month.

Issue conditions:

Without recipe

Packaging:

10 ml - a bottle dropper polyethylene (1) - packs cardboard.