Streptonitol-Darnitsa

General characteristics. Structure:

Active ingredient: 1 g of ointment contains streptocide 50 mg, Nitazolum of 20 mg;

excipients: propylene glycol, liquid paraffin, a macrogoal cetostearyl ether, cetostearyl alcohol, the water purified.

Pharmacological properties:

Стрептонитол®-Дарница – the combined drug for topical treatment of contaminated wounds containing streptocide and Aminitrazolum (Nitazolum). Thanks to such combination of active ingredients the range of antibacterial effect of drug considerably extends, its bactericidal efficiency amplifies. Drug has antibacterial effect on the main activators of pyoinflammatory processes: pyocyanic and intestinal sticks, staphylococcus, streptococci, obligate anaerobic bacteria both spore-forming (clostridiums), and asporogenic (bacteroids, peptokokk, peptostreptokokk), including antibiotic-resistant strains, and also anti-protozoan action on many species of protozoa, including a trichomonad. Drug possesses the antiinflammatory action caused by existence of Aminitrazolum and hydrophilic properties of a basis. Drug has moderate giperosmolyarny activity owing to what has moderate anti-exudative effect. Streptonitol®-Darnitsa ointment protects the granulating wounds from consecutive infection and interferes with formation of the necrosis centers in them.

Controlled researches of pharmacokinetics at the person were not conducted. However in experiments on large laboratory animals it is established that at topical administration of Streptonitol®-Darnitsa ointment Nitazolum and streptocide get into the fabrics surrounding a wound in the concentration providing antibacterial effect not only on a wound surface but also in such fabrics. Absorption in a system blood stream at the same time minimum.

Indications to use:

Purulent wounds in the course of final cleaning from it is purulent - necrotic contents (in the absence of big exudations) and preparation for regeneration.

Burns of the I-IV degree in a stage of alteration, exudation, formation and rejection of a scab. Preparation of a burn surface for an autodermoplastika and elimination in wounds of a purulent infection.

Decubituses, trophic ulcers, cracks, diabetic gangrene, erysipelatous inflammation.

The atopic dermatitis complicated by a bacterial infection.

Acne rash, pyoderma.

Route of administration and doses:

Streptonitol®-Darnitsa ointment is applied locally.

After the processing of wounds and burns including removal of necrotic fabrics and purulent exudate, washing by any disinfecting solution (for example, the following solutions can be used: 0,01% of a miramistin, 3% of peroxide of hydrogen, Furacilin 1:5000 or 0,05 of % of a hlorgeksidin of a biglyukonat) apply ointment a thin layer on the struck surface then apply a sterile gauze bandage or drug apply on a dressing material, and then on a wound.

At treatment of purulent wounds drug is used by 1-2 times a day. At treatment of burns –    1 time within 1-2 days. At treatment of skin infectious diseases – 2 times a day within 1-3 weeks. The dose of drug depends on the area of a wound surface. Duration of treatment is defined by dynamics of healing of wounds.

Features of use:

Use of ointment is not recommended on wounds with big purulent exudation. At emergence of allergic reaction in a site of application of ointment it is necessary to stop drug use.

The premature termination of treatment by drug can cause development of microorganisms, steady against streptocides.

During therapy plentiful alkaline drink is recommended.

Use during pregnancy or feeding by a breast.

Drug is contraindicated.

Ability to influence speed of response at control of motor transport or work with other mechanisms.

Does not influence.

Children.

Safety and efficiency of use of Streptonitol®-Darnitsa ointment for children is not established therefore children are not recommended to use drug.

Side effects:

From skin: erubescence, moknuty, an itch, rash on skin, a peeling.

Allergic reactions: small tortoiseshell, Quincke's edema, face edema.

There can sometimes be a feeling of heat and insignificant morbidity in a drug site of application. At the same time it is not necessary to stop treatment by drug, and the wound surface needs to be processed previously solution of local anesthetic.

At prolonged use of high doses on big sites of skin – systemic action: the complicated breath, compression in a breast, fever, a fever, a headache, a pharyngalgia, dyspepsia, a leukopenia, an agranulocytosis, nausea, vomiting, a dysuria, a crystalluria.

Interaction with other medicines:

Ointment should not be applied on the struck surface along with other medicines. At use of Streptonitol®-Darnitsa ointment it is undesirable to use such drugs as digitoxin, Acidum hydrochloricum, caffeine, a phenylephine hydrochloride, phenobarbital, Adrenalinum hydrochloricum.

Contraindications:

Hypersensitivity to streptocide, Nitazolum or to any of auxiliary components of drug. Pregnancy, feeding period breast.

Overdose:

Cases of overdose of drug are not revealed.

Storage conditions:

Period of validity. 2 years. To store in the place, unavailable to children, in original packaging at a temperature from 15 °C to 25 °C.

Issue conditions:

Without recipe

Packaging:

On 15 g in a tuba, on 1 tuba in a pack.