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Inosine

Препарат Рибоксин. ОАО "Биохимик" Республика Мордовия


Producer: JSC Biokhimik Republic of Mordovia

Code of automatic telephone exchange: C01EB

Release form: Firm dosage forms. Tablets.

Indications to use: Coronary heart disease. Myocardial dystrophy. Acute myocardial infarction. Arrhythmia. Glikozidny intoxication. Hepatitis. Cirrhosis. Liver dystrophy. Late skin porphyria.


General characteristics. Structure:

Active ingredient: 200 mg of inosine (inosine).

Excipients: a kernel – potato starch, methyl cellulose, sugar, polyvinylpirrolidone (povidone), the twin – 80 (polysorbate), stearic acid, sodium carboxymethylstarch (примогель); a cover – methyl cellulose, a hypro rod (hydroxypropyl cellulose), titanium dioxide, the twin – 80 (polysorbate), a silicone emulsion, tropeolin O.

Metabolic means which has anti-hypoxemic, metabolic and antiarrhytmic effect.




Pharmacological properties:

Pharmacodynamics. Metabolic means, predecessor of adenosinetriphosphate. Increases power balance of a myocardium, improves koroyonarny blood circulation, prevents effects of intraoperative ischemia of kidneys. Is directly involved in exchange of glucose and promotes activation of exchange in the conditions of a hypoxia and in the absence of adenosinetriphosphate. Activates metabolism of pyruvic acid for ensuring normal process of tissue respiration, and also promotes activation of a xanthinedehydrogenase. Stimulates synthesis of nucleotides, increases activity of some enzymes of a tricarbonic acid cycle. Getting into cells, raises energy level, has positive effect on processes of exchange in a myocardium, increases force of reductions of heart and promotes fuller relaxation of a myocardium in a diastole therefore the stroke output of blood increases.

Reduces aggregation of thrombocytes, activates an angenesis (especially a myocardium and a mucous membrane of digestive tract).

The pharmacokinetics is Well absorbed in digestive tract. It is metabolized in a liver with formation of glucuronic acid and the subsequent its oxidation. In insignificant quantity it is allocated with kidneys.


Indications to use:

Appoint the adult in complex therapy of coronary heart disease, a myocardial dystrophy, after a myocardial infarction, the disturbances of a heart rhythm caused by use of cardiac glycosides. Appoint at hepatitises, cirrhosis, fatty dystrophy of the liver caused by alcohol or medicines and urokoproporfiriya.


Route of administration and doses:

Appoint inside to food. The daily dose at intake makes 0,6-2,4 g. In the first days of treatment the daily dose is equal to 0,6-0,8 g (on 200 mg 3-4 times a day).

In case of good tolerance the dose is raised (for 2-3 day) to 1,2 g (0,4 g 3 times a day), if necessary - to 2,4 g a day.

Course duration - from 4 weeks to 1,5-3 months. At an urokoproporfiriya the daily dose makes 0,8 g (on 200 mg 4 times a day). Drug is accepted daily within 1-3 months.



Side effects:

Allergic reactions in the form of a small tortoiseshell, a skin itch, a dermahemia are possible (drug withdrawal is required). Seldom at treatment by drug concentration of uric acid in blood and an exacerbation of gout (increases at prolonged use).



Contraindications:

Hypersensitivity, gout, hyperuricemia.

With care - a renal failure.



Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. In the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.


Issue conditions:

According to the recipe


Packaging:

Tablets, film coated, 200 mg. On 10 tablets in a blister strip packaging. 5 planimetric packagings together with the application instruction put in a pack from a cardboard.



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