Спарекс®

General characteristics. Structure:

Active agent of a mebeverin hydrochloride of 200 mg;
excipients: silicon dioxide colloid (aerosil), gipromelloz (gidroksipropilmetiltsellyuloza of brand Benetsel MP 874), povidone (пласдон K 90, коллидон 90 F), magnesium stearate;
structure of a gelatinous solid capsule: the case and a lid — titanium dioxide, gelatin, dye quinolinic yellow, dye a sunset yellow.

Description: Capsules No. 1 of yellow color. Contents of capsules — mix of granules and powder of white or almost white color. Existence of lumps is allowed.

Pharmacological properties:

The spasmolysant of myotropic action, has direct effect on smooth muscles of digestive tract (mainly a large intestine). Eliminates a spasm without influence on a normal peristaltics of intestines. Inhibits phosphodiesterase. Stabilizes the level of cyclic adenosinemonophosphoric acid. Does not possess anticholinergic action.

Pharmacokinetics. At intake is exposed to presistemny hydrolysis and it is not found in plasma. It is metabolized in a liver to the veratric acid and mebeverinovy alcohol. It is removed mainly by kidneys in the form of metabolites, in small amounts — bile. Capsules of a mebeverin have property of long release. Even after multiple dose considerable cumulation is not observed.

Indications to use:

At adults
Spasm of bodies zheludochno — an intestinal path (including caused by an organic disease), intestinal colic, bilious colic, an irritable colon.

At children is more senior than 12 years
The functional disorders of digestive tract which are followed by an abdominal pain.

Route of administration and doses:

Inside to adults and children 12 years on 1 capsule (200 mg) 2 times a day in 20 min. prior to food are more senior (in the morning and in the evening).

To swallow entirely, washing down with water.

Features of use:

During treatment it is necessary to abstain from driving of motor transport and occupations potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

Dizziness, headache, diarrhea, lock. Allergic reactions: small tortoiseshell, Quincke's edema, face edema and dieback.

Contraindications:

Hypersensitivity, porphyria, pregnancy, children's age up to 12 years.
With care: Lactation period.

Overdose:

Symptoms: excitement of the central nervous system. The specific antidote is unknown. The gastric lavage and symptomatic therapy is recommended.

Storage conditions:

List B. To store in the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 2 years. Not to apply until expiry date.

Issue conditions:

According to the recipe

Packaging:

Capsules of the prolonged action on 200 mg.
On 10 or 15 capsules in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished.
On 1, 3, 6 blister strip packagings on 10 capsules or on 2, 4 blister strip packagings on 15 capsules together with the application instruction in a pack from a cardboard.