Aminosteril N-Gepa
Producer: Fresenius Kabi Gmbh (Frezenius Kabi) Germany
Code of automatic telephone exchange: B05BA01
Release form: Liquid dosage forms. Solution for infusions.
General characteristics. Structure:
Active ingredients: 10,4 g of L-izoleytsina, 13,09 g of a L-leucine, 9,71 g of a L-lysine of monohydrate that corresponds to 6,88 g of a L-lysine, 1,1 g of L-methionine, 700 mg of N-acetyl-L-cysteine that corresponds to 520 mg of L-cysteine, 880 mg of L-phenylalanine, 4,4 g of L-threonine, 700 mg of L-tryptophane, 10,08 g of L-valine, 10,72 g of L-arginine, 2,8 g of a L-histidine, 5,82 g of glycine, 4,64 g of L-alanine, 5,73 g of L-proline, 2,24 g of L-serine, 4,42 g of acetic acid ice.
The general content of nitrogen of 12.9 g/l, the general concentration of amino acids of 80 g/l, рН 5.7-6.3, titrable acidity on NaOH of 12-25 mmol/l, theoretical osmolarity 770 ¼Äß¼/l.
Excipients: water for injections.
Pharmacological properties:
Pharmacodynamics. Drug for parenteral food (solution of amino acids). Specially adapted solution for patients with abnormal liver functions containing high amount of branched amino acids and arginine, and low – branched amino acids.
Indications to use:
— parenteral administration of amino acids (Aminosteril N-GEPA of 8%) at heavy abnormal liver functions (liver failure) with or without disturbances of functions of a brain (encephalopathy);
— therapy of abnormal liver functions (hepatic coma).
Route of administration and doses:
For in/in injections. If there are no other instructions, then appoint 1.0-1.25 ml/kg of mass of body/h that makes 0.08-0.1 g of amino acids / 1 kg of body weight of the patient.
Maximum dose: 1.5 of amino acids/kg of body weight/days, i.e. 1300 ml/days at the body weight of sick 70 kg.
Aminosteril N-GEPA of 8% apply while parenteral food is required i.e. while therapy is necessary.
Features of use:
Use at pregnancy and feeding by a breast. About results of use of drug for pregnant women it is not reported.
Use at renal failures. Contraindicated: heavy renal failures (renal failure).
Use for children. About results of use of drug for children it is not reported.
Special instructions. Use Aminosteril is reasonable N-GEPA of 8% only within the provided indications.
Control of level of electrolytes of blood serum (ionogramm), water balance and a condition of acid-base equilibrium is necessary.
About results of use of drug for children it is not reported.
Side effects:
In/in introduction Aminosteril of N-GEPA of 8%, as well as other special solutions, can lead to increase in release of acid and a gastric juice and to an exacerbation of an ulcer. Therefore it is necessary to check previously need of preventive introduction of H2 – antagonists.
Contraindications:
— disturbances of exchange of amino acids of an extrahepatic etiology;
— overhydratation;
— gipokalemiya;
— hyponatremia;
— heavy renal failures (renal failure);
— heavy dysfunctions of heart (heart failure).
Storage conditions:
To store at a temperatus it is not above 25 °C in the place protected from light. To apply only if solution is transparent and packaging is not damaged. To store drug in the place, unavailable to children.
Issue conditions:
According to the recipe
Packaging:
500 ml - bottles of colourless glass (10) - a box cardboard.
500 ml - bottles of colourless glass with holders plastic (10) - boxes cardboard.