Энзистал®-П

General characteristics. Structure:

Active ingredients: 89,36 mg of Pancreatinum of powder that is equivalent to activity of amylase of 4200 Units Evr. Pharm., activities of a lipase of 3500 Units Evr. Pharm., activities of protease of 250 Units Evr. Pharm.

Excipients: lactoses monohydrate, cellulose microcrystallic, magnesium stearate, silicon dioxide colloid anhydrous, sodium krakhmalglikolit (type A), a gipromelloz, polyethyleneglycol 6000, titanium dioxide (Е 171), cellulose ацетилфталат, diethyl phthalate, кармоизин (Е 122), wax white.

Pharmacological properties:

Pharmacodynamics. Pancreatinum contains екскреторні pancreas enzymes – the lipase, amylase, trypsin and chymotrypsin participating in digestion of fats, carbohydrates and proteins. Pancreatinum is not soaked up in a digestive tract, and removed with a stake, and its most part is split and we denature in a digestive tract under the influence of digestive juices and bacteria. Its efficiency fermental activity of a lipase, and also effect of trypsin while amylolytic activity matters only at therapy of a mucoviscidosis as even at chronic pancreatitis splitting of food polysaccharides happens without disturbances is decisive factor.

Indications to use:

Dyspepsia, the simultaneous use of hard digested vegetable, greasy and unusual food, the meteorism connected with the above-stated disturbances, acceleration of passing of food in intestines of functional character.

Route of administration and doses:

Adults and children are more senior than 3 years usually accept 1-2 tablets during food, without chewing them and washing down with enough liquid, for example a glass of water.

Depending on a type of food which is eaten or during food for the purpose of fermental replacement therapy in addition take 2-4 pill for severity of a digestive disturbance.

The dose of drug can be changed and is established by the doctor individually.

Duration of use of medicine is established by the doctor in an individual order.

The daily dose of a lipase should not exceed 15 000-20 000 Units. Is. T. on kilogram of body weight.

Features of use:

Drug contains active enzymes which at release in an oral cavity for example, at a tablet chewing, can injure a mucous membrane of an oral cavity with formation of ulcers therefore it is necessary to swallow of tablets whole.

Special cautions. At patients with a mucoviscidosis complications in the form of intestinal impassability therefore in the presence of the symptoms reminding intestinal impassability it must be kept in mind probability of emergence of intestinal strictures are often observed.

Use during pregnancy or feeding by a breast. Use of drug during pregnancy and feeding by a breast perhaps if, according to the doctor, the expected positive effect for mother exceeds potential risk for the fruit/child.

Ability to influence speed of response at control of motor transport or work with other mechanisms. There are no reservations.

Children. Drug is used to children aged from 3 years.

Side effects:

From immune system: allergic reactions of immediate type (skin rash, sneezing, dacryagogue, bronchospasm).

From a digestive tract: at patients with a mucoviscidosis formation of strictures in ileocecal area and the ascending part of a colon after use of high doses of powder from pancreases was observed. There were messages about allergic reactions from a digestive tract (an abdominal pain, nausea, diarrhea, change of character of excrements).

From kidneys and urinary tract: at patients with a mucoviscidosis, especially after use of high doses of drug, removal of uric acid with urine therefore at these patients it is necessary to check its level in urine not to allow a lithogenesis can increase.

In isolated cases there were messages on emergence of such reactions as a small tortoiseshell, a dermahemia, an itch, feeling of heat, tachycardia, weakness, a Quincke's disease.

Interaction with other medicines:

Use of the medicines containing powder from pancreases can lead to reduction of absorption of folic acid that its additional reception can be required.

Action of peroral anti-diabetic means, such as acarbose and миглитол, can decrease at simultaneous use of drug Enzistal P.

Contraindications:

Hypersensitivity to pancreatic enzymes of animal origin or to one of medicine components. Acute pancreatitis or an exacerbation of chronic pancreatitis, however incidental appointment it is possible in an attenuation phase at expansion of a diet if there are signs of the residual or available disorder of function of a pancreas. Obturatsionny impassability of intestines.

Overdose:

Strengthening of side effects is possible. During reception of extremely high doses of other drugs of Pancreatinum were observed a hyperuricemia and гіперурикозурія. Symptomatic treatment.

Storage conditions:

To store at a temperature not above 25 °C in original packaging. To store in the place, unavailable to children. Godnsta term - 3 years.

Issue conditions:

Without recipe

Packaging:

On 10 tablets at the blister, on 2 blisters in cardboard packaging.