Normanut

General characteristics. Structure:

Acting veshchestvo:1 the capsule contains 250 mg of the lyophilized dry Saccharomyces boulardii yeast with a minimum of 1010 cells/g that includes: 221,25 mg of yeast and 28,75 mg of lactose monohydrate.

excipients: lactose anhydrous, magnesium stearate, gelatin, titanium dioxide (Е 171), ferrous oxide hydrate (Е 172), copper complex of chlorophyllin (Е 141), water.

Pharmacological properties:

Normanut promotes recovery of normal intestinal microflora, has the expressed etiopatogenetichny anti-diarrheal effect. When passing through digestive tract of Saccharomyces boulardii have biological protective action concerning normal intestinal microflora.

Main mechanisms of action Saccharomyces boulardii:

- direct antagonism (antimicrobic action), is connected with ability of Saccharomyces boulardii to contain growth pathogenic and opportunistic microorganisms and mushrooms which break a microbiocenosis of intestines, such as Clostridium difficile, Clostridium pneumoniae, Staphilococcus aureus, Pseudomonas aeruginosa, Candida krusei, Candida pseudotropical, Salmonella typhi, Ecsherichia coli, Shigella dysenteriae, Proteus, and also Enthamoeba hystolitica, Lambliae;

- anti-toxic action is caused by production of proteases that is divided by toxin and a receptor to an enterocyte which toxin contacts (especially in the relation to Clostridium dificile cytotoxin A);

- anti-secretory action (reduces secretion of water and salts) is provided by decrease in formation of tsAMF in enterocytes;

- strengthening of a nonspecific host defense owing to increase in products and secretory immunoglobulins of components of immunoglobulins;

- enzymatic activity is caused by increase in activity of disaccharidases of a small intestine (lactase, sucrose, maltase);

- trophic effect concerning a mucous membrane of a small intestine owing to release of spermine and to a sperm_din.

Resistance of Saccharomyces boulardii to action of antibiotics is genetically caused allows to apply them along with antibiotics to protection of a normal microbiocenosis of a digestive tract.

After reception to Normagut high concentration of Saccharomyces boulardii in a large intestine is quickly reached that is supported within a day. Saccharomyces boulardii do not get into a system blood stream and mezenterialny lymph nodes. After the end of treatment Saccharomyces boulardii are completely removed with a stake within 3-5 days.

Indications to use:

Acute infectious (a bacterial, virus etiology) diarrhea at children and adults; prevention and treatment of diarrhea and the colitis caused by an antibioticotherapia; prevention and treatment of pseudomembranous colitis and the recurrent diseases caused by Clostridium difficile; syndrome of the angry intestines; the prevention of diarrhea at long pirenteralny food.

Route of administration and doses:

Capsules accept inside, swallowing entirely and washing down with enough liquid (1 glass of drinking water). For children age up to 6 years it is necessary to open the capsule and to pour out its contents in 50 ml of water of room temperature (20 - 25 degrees).

 

For prevention of diarrhea

To adults and children 12 years are more senior: on 1 capsule 1 - 2 times a day.

To children aged from 2 up to 12 years: on 1 capsule 1 - 2 times a day.

 

For prevention of diarrhea during the travel:   in 5 days before departure by the adult and to children 12 years - on 1 capsule 1 - 2 times a day are more senior, children are 2-12 years old - on 1 capsule a day.

 

For prevention of diarrhea during treatment by antibiotics and streptocides: drug is used along with antibiotics and streptocides from the first day of an antibioticotherapia and by some more days after its end. To adults and children 12 years - on 2 capsules 2 times a day, to children from 2 to 12 years - on 1 capsule 2 times a day are more senior.

 

For treatment of acute diarrhea

To adults and children 2 years are more senior appoint on 1-2 capsule a day within 4-7 days (250-500 mg).

At the diarrhea caused by feeding via the probe: daily add the maintenance of 3 capsules (750 mg) to 1,5 l of solution for periteralny food (composition of solution and duration of treatment the doctor depending on a condition of the patient and laboratory indicators defines).

Features of use:

Use during pregnancy or feeding by a breast.

It is not necessary to use drug during pregnancy and feeding by a breast as experience of a clinical use is absent.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Does not influence.

Children. It is not necessary to use drug to children under 2 years.

Side effects:

In isolated cases the short-term discomfort in epigastriums is possible that it does not demand the termination of administration of drug.

Interaction with other medicines:

Co-administration with antimikotichny means at their system use leads Normaguta to an inactivation of active agent.

Contraindications:

Hypersensitivity to any of drug components.

Overdose:

At accidental exceeding of a therapeutic dose does not cause negative reaction. At considerable overdose there can be a meteorism, nausea, vomiting.

Treatment: gastric lavage, use of absorbent carbon and/or symptomatic therapy.

Storage conditions:

Period of validity. 2 years. To store in dry, protected from light and the place, unavailable to children, at a temperature not above 25 °C.

Issue conditions:

Without recipe

Packaging:

On 10 capsules in the blister. On 3 blisters in an individual bag and the instruction is put in a box from a cardboard.