Testosterone C

General characteristics. Structure:

Active ingredient: 100 mg or 200 mg of testosterone of a tsipionat.

Excipients: benzyl alcohol, benzyl benzoate, oil peach or peanut.

Androgenic hormone.

Pharmacological properties:

Pharmacodynamics. Testosterone ципионат is testosterone ether. Testosterone is primary male sex hormone synthesized and emitted by testicles. It stimulates growth and development of men's generative organs and secondary sexual characteristics (maturing of a prostate, seed bubbles, a penis and a scrotum), distribution of hair on men's type on a face, a pubis, a breast), development of a throat, muscles of a body and fat distribution. Nitrogen, sodium, potassium and phosphorus detains, strengthens anabolism and reduces a catabolism of proteins. Premature increase in concentration of testosterone in a blood plasma during the period before puberty causes closing of an epiphysis and suspension of growth. Stimulates products of erythropoetin and erythrocytes. On a negative feedback mechanism (feedback) oppresses secretion of luteinizing and follicle-stimulating hormones of a hypophysis and the spermatogenesis oppresses. At men with primary hyper gonadotropic hypogonadism normalization of level of gonadotrophins is noted.

At women oppresses gonadotropic function of a hypophysis, function of ovaries, mammary glands, causes an endometria atrophy. Antagonistic action in relation to estrogen is applied at treatment of myomas, endometriosis, breast cancer. Shows beneficial effect at complaints of a climacteric.

Pharmacokinetics. Testosterone ципионат it is soaked up slowly. The maximum concentration in blood is noted in 72 h after introduction. Action continues 2-4 weeks. In blood of nearly 98% of testosterone contacts the specific fraction of globulins connecting testosterone and oestradiol. Biotransformation occurs in a liver to various 17 ketosteroids which after conjugation with glucuronic or sulphuric acid are allocated with urine (about 90%). About 6% of the absorbed drug are removed with a stake in an untied look.

Indications to use:

Men have a gormonozamestitelny therapy at the disturbances connected with deficit of testosterone:

- puberty delay;
- eunuchoidism, underdevelopment of generative organs;
- endocrine impotence;
- hypopituitarism;
- symptoms of a men's climax (decrease in a libido, intellectual and physical activity);
- a postkastratsionny syndrome (deficit of androgens after castration);
- the osteoporosis caused by androgenic insufficiency.

At women:

- hyperestrogenism, functional bleedings;
- hysteromyoma;
- endometriosis;
- a climax (in combination with estrogen);
- breast cancer;
- osteoporosis.

Route of administration and doses:

Intramusculary, it is deep in a gluteus. The mode of dosing is selected individually, depending on a disease, a sex, age, clinical effect.

As a rule, the adult enter intramusculary 50-200 mg in 2-4 weeks.

It is not recommended to exceed a dose of 400 mg a month. Duration of treatment is established individually.

At a hypogonadism men as an eunuchoidism the recommended doses – to 50-400 mg have each 2-4 weeks.

At a delay of puberty about 50-200 mg are applied each 2-4 weeks 4-6 months.

At a breast cancer at women: on 200-400 mg each 2-4 weeks.

The drug cannot be administered intravenously!

Features of use:

In case of androgenzavisimy side reactions treatment by testosterone should be stopped. After disappearance of side effects to resume treatment in lower doses.

Patients with the latent or expressed heart failure, a renal failure, hypertensia, epilepsy or migraine (or existence of these states in the anamnesis) are subject to constant observation as androgens can cause a delay of sodium and water in some cases. At long reception to check functions of a liver. At patients with cancer of a mammary gland, a hypernephroma, lung cancer with metastasises in bones to check calcium level in blood and urine.

At boys in the prepubertatny period androgens have to be applied with care in order to avoid premature closing of an epiphysis and the accelerated sexual development.

Side effects:

Priapism and other signs of excess sexual stimulation (frequent erection);

boys in the prepubertatny period have an accelerated sexual development, increase in frequency of erections, increase in a penis and premature closing of an epiphysis;

damage of a spermatogenesis and disturbance of maturing of spermatozoa, oligospermatism and decrease in volume of an ejaculate;

anomalies of a prostate;

women have a bleeding from patrimonial ways, strengthening of a libido; at long use of drug virilescence symptoms are possible;

hirsutism, gynecomastia;

seborrhea, eels, fat skin, the accelerated hair loss;

delay of sodium and water, hypostases;

hypercalcemia symptoms;

thrombophlebitis;

nausea, cholestatic jaundice, increase in level of aminotransferases of a liver (in process of the termination of reception are normalized);

headache, depression, aggression, alarm, sleep disorder, paresthesias.

Pain, itch and hyperemia in the place of an injection are possible.

Interaction with other medicines:

Increases efficiency of anticoagulants and hypoglycemic means (it is necessary to change doses), inhibits cyclosporine removal. Inductors of liver enzymes (barbiturates, rifampicin, carbamazepine, phenylbutazone, Phenytoinum) reduce effect of testosterone.

Contraindications:

The increased individual sensitivity to drug components, a carcinoma of a prostate or mammary gland; a prostatauxe with symptoms of disturbance of an urination; nephrosis or nephrotic phase of nephrite, hypostases; hypercalcemia; abnormal liver function; diabetes mellitus; heart and coronary failure, a myocardial infarction in the anamnesis, atherosclerosis at elderly men; pregnancy, feeding by a breast.

Overdose:

At acute overdose toxicity of testosterone extremely low. At chronic overdose development of a priapism is possible. In this case treatment should be stopped, and after disappearance of symptoms - to begin in smaller doses.

Storage conditions:

To store at a temperature of 15-25 °C, in dry, protected from light and the place, unavailable to children. Period of validity of 5 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for injections of oil 100 mg/ml and 200 mg/ml on 1 ml or 2 ml in ampoules and on 2 ml, 5 ml or 10 ml in bottles.