Ammifurin

General characteristics. Structure:

Active agent: an ammifurina — 300 mg.

Excipients (alcohol of ethyl 95%, glycerin, the water purified) — to 100 ml.

Pharmacological properties:

Аммифурин® represents the sum of a furokumarinov:izopimpinellin, bergapten and xanthotoxinum allocated from fruits of an amma big — Ammi majus L, family celery (umbrella) — Apiaceae (Umbelliferae).
Аммифурин® has the photosensitizing effect.

Indications to use:

Аммифурин® apply at adults at vitiligo, gnezdny and total baldness, psoriasis.

Route of administration and doses:

Аммифурин® appoint in combination with ultra-violet radiation (Ural federal district). Ammifurina® solution is applied outwardly, inflicting on the centers defeats in 1 hour prior to radiation.
At common forms of a disease outside application of drug is combined with its intake.
At psoriasis procedures are carried out by 4 times a week. UF-radiation is begun about 1/2 biodoses, gradually increase up to 5–6 biodoses that corresponds (depending on individual sensitivity of the patient to Uv-radiation) to radiation duration from 1–2 minutes to 10–15 minutes. Total quantity of radiation makes 15–20 procedures. Treatment of patients with psoriasis can be carried out in combination with long-wave Uv-radiation.
At vitiligo, gnezdny and total baldness radiation is carried out by 3 times a week (every other day) — 20–25 radiations. In total conduct 4–6 courses.
The patient with the limited centers of defeat of Ammifurin® appoint only outwardly in the form of 0,3% of solution with the subsequent Ural federal district. The center of defeat is greased by 0,3% with Ammifurina® solution in 1 hour prior to radiation. Procedures are carried out by 3–4 times a week. Ural federal district is begun about 1/2 biodoses, gradually increase up to 5–6 biodoses. The number of procedures depends on results of treatment and make in general 20–25 radiations. In summertime radiation by a quartz lamp in all cases can be replaced with the dosed solar insolation.
Course dose Аммифурина® 1–2 bottles of 0,3% of solution on 50 ml (0,15–0,3 g). Repeated courses are conducted at an interval of 1–1,5 months.

Features of use:

It is necessary to be careful at the use of the products and cosmetics containing the photosensitizing substances.
For radiation avoidance probably of the healthy skin surrounding the sklerodermichesky centers at local influence it is greased, at distance of 1-2 cm from defeat borders, with zinc paste or photoprotective cream. After the procedure zinc paste is deleted with the cotton plug moistened with vegetable oil.
At common forms of a disease outside application of Ammifurina® solution is combined with its intake in the form of tablets on 20 mg. Drug is used after food, washing down with milk, in a dose of 0,8 mg/kg, but no more than 80 mg on reception, once, in 2 hours prior to Ural federal district.

Side effects:

Secondary xanthopathy, moderate erythema, itch.

Interaction with other medicines:

Strengthens action of other photosensitizers (including the photosensitizing foodstuff and cosmetics).
The specified therapy can be carried out against the background of the standard drug treatment including use of penicillin, a lidaza, vascular drugs, outside means.

Contraindications:

Intolerance of Ural federal district and Psoralenums, the diseases which are followed by hypersensitivity to light (albinism, a system lupus erythematosus, etc.), in combination with Ural federal district at the following diseases: tuberculosis, thyrotoxicosis, diseases of blood, liver, kidneys, cardiovascular system, idiopathic hypertensia of the II-III degree, disease of the central nervous system, diabetes, pregnancy, lactation period, cataract, multiple pigmental nevus, benign and malignant tumors.

Overdose:

At overdose of solar and artificial UF-radiation there can be acute dermatitis (the erythema, hypostasis, are possible bubbles). In this case treatment should be stopped to permission of the phenomena of dermatitis.

Storage conditions:

List B. In protected from light and the place, unavailable to children, at a temperature not above 25 °C.

Issue conditions:

According to the recipe

Packaging:

Solution for external use.
On 50, 100, 1000 and 5000 ml in bottles of orange glass. Each bottle with a capacity of 50 ml and 100 ml together with the application instruction is placed in a pack from a cardboard.