Mycocide

General characteristics. Structure:

Active ingredient: 10 mg of a bifonazol in 1 g of gel.

Excipients: alcohol, propylene glycol, macrogoal 400, carbomer, glycerin, dimethyl sulfoxide.

Antifungal broad-spectrum agent. Depending on a dose has fungistatic or fungicidal property.

Pharmacological properties:

Pharmacodynamics. Bifonazol – antifungal broad-spectrum agent. Depending on a dose has fungistatic or fungicidal property. The mechanism of effect of medicine is caused by disturbance of synthesis of the ergosterol which is a part of a cellular membrane of mushrooms. It is active concerning dermatophytes, barmy (including the sorts Candida), mold (Malassezia furfur) and other mushrooms, gram-positive cocci. Also Corynebacterium minutissimum, Piturosporum orbiculare are sensitive to medicine.

Pharmacokinetics. After topical administration of a bifonazol only 0,6 – 0,8% of active agent are absorbed from the surface of healthy skin and 2 – 4% - at inflammations of the skin.

The elimination half-life makes 19 – 32 hours. In 6 hours concentration of a bifonazol in upper and papillary layers of epidermis corresponds or many times over exceeds the minimum overwhelming concentration for the main activators of dermatomycoses.

Indications to use:

- the dermatomycoses caused by dermatophytes, barmy, mold and other mushrooms including mycoses of feet, brushes, smooth skin and folds of skin;
- multi-colored deprive, superficial candidiases;
- erythrasma.

Route of administration and doses:

Gel is applied once a day in the evening before going to bed with a thin layer on an affected area of skin and rubbed. The single dose is established taking into account the defeat center sizes – for processing of the area of the size of a palm use a column of gel about 5 mm long.

Treatment duration at mycoses of feet and damage of skin in interdigital intervals of legs – 3 weeks; at mycoses of brushes, folds of skin and smooth skin – 2–3 weeks; at multi-colored herpes and an erythrasma – 2 weeks; at superficial candidiases – 2-4 weeks.

Features of use:

To apply with care at the patients having hypersensitivity to other antifungal medicines from group of derivatives of an imidazole (эконазол, Clotrimazolum, Miconazolum).

To avoid hit of medicine in eyes.

The propylene glycol which is a part of medicine can cause irritation of skin.

Use for children is possible only under observation of the doctor.

Use at pregnancy and feeding by a breast. Pregnancy. Use of medicine during pregnancy is contraindicated.

Lactation period. There are no data on penetration of a bifonazol into breast milk. During treatment breastfeeding needs to be stopped.

Influence on ability to drive the car and moving mechanisms. Does not influence.

Side effects:

Allergic and local reactions are possible (an easy hyperemia, irritation of skin, in some cases – burning and a pricking).

Interaction with other medicines:

Are not described.

Contraindications:

Hypersensitivity to an imidazole and its derivatives, and also to medicine components.

Overdose:

In case of an accidental proglatyvaniye of gel the gastric lavage has to be immediately carried out.

Storage conditions:

In the place protected from light at a temperature not above +25 °C. To store in the place, unavailable to children. Period of validity 2 years. A period of storage after opening of packaging of 28 days.

Issue conditions:

According to the recipe

Packaging:

On 30,0 g and 50,0 g in the tubas placed together with a leaf insert in packs from a cardboard.