Producer: RUP of Belmedpreparata Republic of Belarus
Code of automatic telephone exchange: A01AD11, D03AX
Release form: Soft dosage forms. Ointment.
General characteristics. Structure:
Active ingredient: 100 mg of a biyen, 5 mg of a dioxidin.
Reparef-1 — wound healing and antiburn means, has regenerantny and reparantny properties.
Pharmacodynamics. An effective agent of Reparef-1 ointment is биен — the complex of ethyl ethers of polyunsaturated fatty acids stabilized α-tocopherol by acetate (vitamin E). Essential fatty acids — arachidonic (the predecessor of prostaglandins and leukotrienes), olein, linoleic and linolenic (vitamin F), being the most important components of biological membranes and a source of bioregulators of cells and fabrics are a part of a biyen.
The Polietilenoksidny ointment basis having high hydrophily provides increase in bioavailability of a biyen and anti-hydration effect when putting ointment on the wet wound and burned surface, on mucous membranes, promotes manifestation of wound healing properties of drug in the first phase of a wound process. Use of ointment for patients with erosive cankers of a mucous membrane of a mouth promotes reduction of a pain syndrome, decrease in the inflammatory phenomena, reduction of an erythema, essential acceleration of epithelization and more bystry healing.
Pharmacokinetics. Practically it is not soaked up through the unimpaired skin and mucous and does not get to a system blood stream. Through the injured skin and a mucous membrane it is soaked up in insignificant quantities.
Indications to use:
Erosive cankers of a mucous membrane of a mouth (traumatic ulceration; crack of a red border of a lip; flat deprive, manifestations in an oral cavity; a lip herpes simplex (recurrent), herpetic gingivostomatitis at a proliferation stage; recurrent afta of an oral cavity; the erythema is mnogoformny, manifestations in an oral cavity).
Route of administration and doses:
Reparef-1 ointment give a thin layer on a surface wounds, ulcers or a burn after their primary surgical treatment and (or) washing by antiseptic agents. From above apply the sterile gauze bandage impregnated with ointment from the inside. Depending on a state and the area of wounds application is repeated by 1-2 times a day within 4-5 days. For correction of shifts of lipidic exchange at burns along with ointment use inside appoint "биен" in capsules 0,4-0,6 g 3 times a day.
For treatment of erosive cankers of a mucous membrane of a mouth Reparef-1 ointment is applied applikatsionno (on wadded or gauze plates) on erosive and ulcer mucosal surfaces of a cover of a mouth 3-4 times a day before end of epithelization (7-15 days). Duration of application is 5-7 minutes.
Features of use:
Special precautionary measures at use of drug are not required.
In some cases after an initiation of treatment Reparef-1 ointment perhaps passing feeling of easy burning.
Interaction with other medicines:
Cases of negative medicinal interaction at use of Reparef-1 ointment against the background of therapy are noted by the antiseptic agents, antiviral drugs, antibiotics, analgetics, nonsteroid and steroid antiinflammatory drugs and other medicines included in the standard schemes of treatment of wound and ulcer and necrotic damages of skin and mucous membranes, burns and freezing injuries. Reparef-1 ointment is applied at the last stage of topical treatment in 5-10 minutes after application of the previous drug. Meal and drinks is recommended not earlier than in 1-1,5 hours.
Hypersensitivity to a biyen and other components of drug.
Overdose cases at use of Reparef-1 ointment are not described.
According to the recipe
Ointment for external and topical administration in tubas of 15 g.