Keyten

General characteristics. Structure:

Active ingredient: 1 bottle with powder for preparation of injection solution contains a tsefpirom of 0,25, 0,5, 1 or 2 g.

Pharmacological properties:

Pharmacodynamics. It is highly effective concerning gram-positive and gram-negative aerobic and anaerobic microorganisms: E.coli, Salmonella spp., Shigella spp., Proteus mirabilis, Proteus vulgaris, Providencia, Morganella morganii, Citrobacter freundii, Klebsiella oxytoca, Serratia spp., Enterobacter spp., Haemophilus influenzae, Neisseria spp., Moraxella catarrhalis, Streptococcus spp. (including St. pneumoniae), Staphylococcus spp., Peptostreptococcus spp., Clostridium perfringens, Ps. aeruginosa. As the representative of the 4th generation of cephalosporins is steady against action known beta лактамаз.

Pharmacokinetics. At intravenous administration remains in blood in therapeutic concentration during 12 h. Well gets into fabrics and liquids (except spinal) an organism.

Indications to use:

- diseases of the lower respiratory tracts;

- infections of upper and lower parts of an urinary system;

- bacteremia;

- septicaemia;

- bacteremia infection at patients with a neutropenia and the weakened immunity.

Route of administration and doses:

Intravenously. Dosages and a way of introduction select individually, depending on weight of an infection, its localization and from a condition of function of kidneys. Usually each 12 h at an infection of an urinary system, skin or soft tissues enter 1 g, a respiratory organs - 1-2 g, to a septicaemia, bacteremia and patients with a neutropenia - 2 g. At patients with a renal failure the dose depends on creatinine Cl: 5-20 ml/min. - 0,5-1 g/day (once), 20-50 ml/min. - on 0,5-1 g 2 times a day - for the patients who are on a hemodialysis, the daily dose makes 0,5 g, besides, after each procedure enter in addition 0,25 g.

Features of use:

Blocks synthesis of a peptidoglikan of a bacterial wall.

During pregnancy apply only when the expected advantage for mother exceeds potential risk for a fruit. Nursing mothers for the period of treatment have to suspend breastfeeding.

Side effects:

Nausea, vomiting, diarrhea, tranzitorny increase in activity of hepatic transaminases, leukopenia, neutropenia, tranzitorny increase in concentration of urea and creatinine in a blood plasma, morbidity and phlebitis in the place of an injection, allergic reactions (skin rash, an itch, medicinal fever, etc.).

Interaction with other medicines:

Let's combine with normal saline solution, Ringer's solution, 5 and 10% solution of glucose, 5% fructose solution, from 6% the glucose solution mixed from 0,9% by chloride sodium solution.

Contraindications:

Hypersensitivity (including to penicillin, karbopenema, other cephalosporins).

Overdose:

Information on overdose by this drug is absent today.

Storage conditions:

In the dry, protected from light place, at a temperature not above 25 °C.

To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Powder for preparation of solution for injections of 0.5 g in a bottle.